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Browse result for Methylation
※ introduction Protein methylation typically takes place on arginine or lysine amino acid residues in the protein sequence. Arginine can be methylated once (monomethylated arginine) or twice, with either both methyl groups on one terminal nitrogen (asymmetric dimethylated arginine) or one on both nitrogens (symmetric dimethylated arginine) by peptidylarginine methyltransferases (PRMTs). Lysine can be methylated once, twice or three times by lysine methyltransferases. Protein methylation has been most studied in the histones. The transfer of methyl groups from S-adenosyl methionine to histones is catalyzed by enzymes known as histone methyltransferases. Histones that are methylated on certain residues can act epigenetically to repress or activate gene expression. Protein methylation is one type of post-translational modification.
Reference
Wiki: Methylation
Reference
Wiki: Methylation
UniProt AC | Entrez ID | Gene Name | Protein Name | Organism |
---|---|---|---|---|
O00255 | 4221 | MEN1 | Menin | Homo sapiens |
O14727 | 317 | APAF1 | Apoptotic protease-activating factor 1 | Homo sapiens |
O14744 | 10419 | PRMT5 | Protein arginine N-methyltransferase 5 [Cleaved into: Protein arginine N-meth | Homo sapiens |
O15169 | 8312 | AXIN1 | Axin-1 | Homo sapiens |
O15524 | 8651 | SOCS1 | Suppressor of cytokine signaling 1 | Homo sapiens |
O60341 | 23028 | KDM1A | Lysine-specific histone demethylase 1A | Homo sapiens |
O75530 | 8726 | EED | Polycomb protein EED | Homo sapiens |
O88508 | 13435 | Dnmt3a | DNA -methyltransferase 3A | Mus musculus |
O94807 | hTERT | Telomerase transcriptase | Homo sapiens | |
O94813 | 9353 | SLIT2 | Slit homolog 2 protein [Cleaved into: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product] | Homo sapiens |
O95294 | 8437 | RASAL1 | RasGAP-activating-like protein 1 | Homo sapiens |
O95343 | 6496 | SIX3 | Homeobox protein SIX3 | Homo sapiens |
O95715 | 9547 | CXCL14 | C-X-C motif chemokine 14 | Homo sapiens |
P01344 | 3481 | IGF2 | Insulin-like growth factor II [Cleaved into: Insulin-like growth factor II; Insulin-like growth factor II Ala-25 Del; Preptin] | Homo sapiens |
P03372 | 2099 | ESR1 | Estrogen receptor | Homo sapiens |
P10636 | 4137 | MAPT | Microtubule-associated protein tau | Homo sapiens |
P13640 | 4495 | MT1G | Metallothionein-1G | Homo sapiens |
P15056 | 673 | BRAF | Serine/threonine-protein kinase B-raf | Homo sapiens |
P16455 | 4255 | MGMT | Methylated-DNA--protein-cysteine methyltransferase | Homo sapiens |
P23470 | 5793 | PTPRG | Receptor-type tyrosine-protein phosphatase gamma | Homo sapiens |
P26367 | 5080 | PAX6 | Paired box protein Pax-6 | Homo sapiens |
P35637 | 2521 | FUS | RNA-binding protein FUS | Homo sapiens |
P35716 | 6664 | SOX11 | Transcription factor SOX-11 | Homo sapiens |
P38398 | 672 | BRCA1 | Breast cancer type 1 susceptibility protein | Homo sapiens |
P40692 | 4292 | MLH1 | DNA mismatch repair protein Mlh1 | Homo sapiens |
P42336 | 5290 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alp | Homo sapiens |
P43247 | 17685 | Msh2 | DNA mismatch repair protein Msh2 | Mus musculus |
P48431 | 6657 | SOX2 | Transcription factor SOX-2 | Homo sapiens |
P48444 | 372 | ARCN1 | Coatomer subunit delta | Homo sapiens |
P53355 | 1612 | DAPK1 | Death-associated protein kinase 1 | Homo sapiens |
P53779 | 5602 | MAPK10 | Mitogen-activated protein kinase 10 | Homo sapiens |
P60484 | 5728 | PTEN | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | Homo sapiens |
P67775 | 5515 | PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | Homo sapiens |
P84243 | 3020 | H3F3A | Histone H3.3 | Homo sapiens |
Q03164 | 4297 | KMT2A | Histone-lysine N-methyltransferase 2A (Zin | Homo sapiens |
Q12983 | 664 | BNIP3 | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 | Homo sapiens |
Q13362 | 5527 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | Homo sapiens |
Q13454 | 7991 | TUSC3 | Tumor suppressor candidate 3 | Homo sapiens |
Q13761 | 864 | RUNX3 | Runt-related transcription factor 3 (SL3-3 enhancer factor 1 a | Homo sapiens |
Q15910 | 2146 | EZH2 | Histone-lysine N-methyltransferase EZH2 | Homo sapiens |
Q16335 | hMLH1 | HMLH1 protein | Homo sapiens | |
Q16828 | 1848 | DUSP6 | Dual specificity protein phosphatase 6 | Homo sapiens |
Q2TAM9 | 286319 | TUSC1 | Tumor suppressor candidate gene 1 protein | Homo sapiens |
Q5TA31 | 149603 | RNF187 | E3 ubiquitin-protein ligase RNF187 | Homo sapiens |
Q6KDN9 | 15248 | Hic1 | HIC1 protein | Mus musculus |
Q6U949 | 51214 | IGF2-AS | Putative insulin-like growth factor 2 antisense gene protein | Homo sapiens |
Q8N474 | 6422 | SFRP1 | Secreted frizzled-related protein 1 | Homo sapiens |
Q8NI51 | 140690 | CTCFL | Transcriptional repressor CTCFL | Homo sapiens |
Q8WTS1 | 51099 | ABHD5 | 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 | Homo sapiens |
Q96KF2 | 84366 | PRAC1 | Small nuclear protein PRAC1 | Homo sapiens |
Q96QR1 | 92304 | SCGB3A1 | Secretoglobin family 3A member 1 | Homo sapiens |
Q99626 | 1045 | CDX2 | Homeobox protein CDX-2 | Homo sapiens |
Q9H3R0 | 23081 | KDM4C | Lysine-specific demethylase 4C | Homo sapiens |
Q9H5I1 | 79723 | SUV39H2 | Histone-lysine N-methyltransferase SUV39H2 3-9 homolog 2) | Homo sapiens |
Q9JI45 | 3474 | Tfam | Mitochondrial transcription factor A | Rattus norvegicus |
Q9NS23 | 11186 | RASSF1 | Ras association domain-containing protein 1 | Homo sapiens |
Q9UBC3 | 1789 | DNMT3B | DNA -methyltransferase 3B | Homo sapiens |
Q9UKU9 | 23452 | ANGPTL2 | Angiopoietin-related protein 2 | Homo sapiens |
Q9UNQ0 | 9429 | ABCG2 | ATP-binding cassette sub-family G member 2 | Homo sapiens |
Q9Y2J2 | 23136 | EPB41L3 | Band 4.1-like protein 3 [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | Homo sapiens |
Q9Y3E5 | 51651 | PTRH2 | Peptidyl-tRNA hydrolase 2, mitochondrial | Homo sapiens |