Tag | Content |
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UniProt Accession | SOX2_HUMAN; P48431; |
Entrez ID | 6657 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Transcription factor SOX-2 |
Gene Name | SOX2 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). |
Sequence (Fasta) | MYNMMETELK PPGPQQTSGG GGGNSTAAAA GGNQKNSPDR VKRPMNAFMV WSRGQRRKMA 60 QENPKMHNSE ISKRLGAEWK LLSETEKRPF IDEAKRLRAL HMKEHPDYKY RPRRKTKTLM 120 KKDKYTLPGG LLAPGGNSMA SGVGVGAGLG AGVNQRMDSY AHMNGWSNGS YSMMQDQLGY 180 PQHPGLNAHG AAQMQPMHRY DVSALQYNSM TSSQTYMNGS PTYSMSYSQQ GTPGMALGSM 240 GSVVKSEASS SPPVVTSSSH SRAPCQAGDL RDMISMYLPG AEVPEPAAPS RLHMSQHYQS 300 GPVPGTAING TLPLSHM 318 |
|
Database | Annotation |
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Cancer Gene Census | NSCLC, oesophageal squamous carcinoma |
CTD (Curated) (count: 12) (view all) | MESH:C538231
; Adenocarcinoma of lung MESH:D000853 ; Anophthalmos MESH:D002294 ; Carcinoma, Squamous Cell MESH:C531835 ; Esophageal atresia with or without tracheoesophageal fistula MESH:C562729 ; Esophageal Squamous Cell Carcinoma MESH:D008175 ; Lung Neoplasms |
HGMD (count: 33) (view all) | CP035470; Anophthalmia; Complex rearrangements
CP061622; Anophthalmia-esophageal-genital syndrome; Complex rearrangements CD051784; Anophthalmia; Small deletions CD064640; Hypothalamo-pituitary-gonadal axis abnormalities; Small deletions CD082205; Anophthalmia / microphthalmia; Small deletions CD064641; Hypothalamo-pituitary-gonadal axis abnormalities; Small deletions |
PTM | Modification Sites |
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Phosphorylation (count: 9) (view all) | 118 RPRRKTKTLMKKDKY dbPAF
125 TLMKKDKYTLPGGLL dbPAF 126 LMKKDKYTLPGGLLA dbPAF 138 LLAPGGNSMASGVGV dbPAF 246 SMGSVVKSEASSSPP dbPAF 249 SVVKSEASSSPPVVT dbPAF |
Sumoylation (count: 1) | 245 GSMGSVVKSEASSSP PLMD |
Network | Interaction | ||
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A | B | Source | |