| Tag | Content |
|---|---|
| UniProt Accession | BRAF_HUMAN; P15056; |
| Entrez ID | 673 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) |
| Gene Name | BRAF; BRAF1; RAFB1 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway. |
| Sequence (Fasta) | MAALSGGGGG GAEPGQALFN GDMEPEAGAG AGAAASSAAD PAIPEEVWNI KQMIKLTQEH 60 IEALLDKFGG EHNPPSIYLE AYEEYTSKLD ALQQREQQLL ESLGNGTDFS VSSSASMDTV 120 TSSSSSSLSV LPSSLSVFQN PTDVARSNPK SPQKPIVRVF LPNKQRTVVP ARCGVTVRDS 180 LKKALMMRGL IPECCAVYRI QDGEKKPIGW DTDISWLTGE ELHVEVLENV PLTTHNFVRK 240 TFFTLAFCDF CRKLLFQGFR CQTCGYKFHQ RCSTEVPLMC VNYDQLDLLF VSKFFEHHPI 300 PQEEASLAET ALTSGSSPSA PASDSIGPQI LTSPSPSKSI PIPQPFRPAD EDHRNQFGQR 360 DRSSSAPNVH INTIEPVNID DLIRDQGFRG DGGSTTGLSA TPPASLPGSL TNVKALQKSP 420 GPQRERKSSS SSEDRNRMKT LGRRDSSDDW EIPDGQITVG QRIGSGSFGT VYKGKWHGDV 480 AVKMLNVTAP TPQQLQAFKN EVGVLRKTRH VNILLFMGYS TKPQLAIVTQ WCEGSSLYHH 540 LHIIETKFEM IKLIDIARQT AQGMDYLHAK SIIHRDLKSN NIFLHEDLTV KIGDFGLATV 600 KSRWSGSHQF EQLSGSILWM APEVIRMQDK NPYSFQSDVY AFGIVLYELM TGQLPYSNIN 660 NRDQIIFMVG RGYLSPDLSK VRSNCPKAMK RLMAECLKKK RDERPLFPQI LASIELLARS 720 LPKIHRSASE PSLNRAGFQT EDFSLYACAS PKTPIQAGGY GAFPVH 767 |
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| Database | Annotation |
|---|---|
| Cancer Gene Census | melanoma, colorectal, papillary thyroid, borderline ovarian, NSCLC, cholangiocarcinoma, pilocytic astrocytoma, Spitzoid tumour, pancreas acinar carcinoma, melanocytic nevus, prostate, gastric |
| CTD (Curated) (count: 27) (view all) | MESH:C538231
; Adenocarcinoma of lung MESH:D018268 ; Adrenocortical Carcinoma MESH:D000564 ; Ameloblastoma MESH:D001254 ; Astrocytoma MESH:D063646 ; Carcinogenesis MESH:D006528 ; Carcinoma, Hepatocellular |
| HGMD (count: 41) (view all) | CD086088; Cardio-facio-cutaneous syndrome; Small deletions
CG086089; Cardio-facio-cutaneous syndrome; Gross deletions CM076028; Costello syndrome; Missense/nonsense CM092078; Noonan syndrome; Missense/nonsense CM092077; Noonan syndrome; Missense/nonsense CM072907; Cardio-facio-cutaneous syndrome; Missense/nonsense |
| GWASdb (count: 11) (view all) | rs6464036; Type 2 diabetes; type 2 diabetes mellitus
rs1267638; Height; Null rs1267648; Multiple complex diseases; Null rs1267612; Multiple complex diseases; Null rs13241719; Response to Vitamin E supplementation; cancer|diabetes mellitus|cardiovascular system disease rs1267619; Height; Null |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 43) (view all) | 119 SSSASMDTVTSSSSS dbPAF
147 NPTDVARSNPKSPQK dbPAF 151 VARSNPKSPQKPIVR dbPAF 244 FVRKTFFTLAFCDFC dbPAF 319 LTSGSSPSAPASDSI dbPAF 333 IGPQILTSPSPSKSI dbPAF |
| Acetylation (count: 2) | 154 SNPKSPQKPIVRVFL PLMD
418 TNVKALQKSPGPQRE PLMD |
| Ubiquitination (count: 6) | 164 VRVFLPNKQRTVVPA PLMD
253 AFCDFCRKLLFQGFR PLMD 601 DFGLATVKSRWSGSH PLMD 680 YLSPDLSKVRSNCPK PLMD 698 RLMAECLKKKRDERP PLMD 88 AYEEYTSKLDALQQR PLMD |
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