| Tag | Content |
|---|---|
| UniProt Accession | RN187_HUMAN; Q5TA31; |
| Entrez ID | 149603 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | E3 ubiquitin-protein ligase RNF187 (EC 2.3.2.27) (RING domain AP1 coactivator 1) (RACO-1) (RING finger protein 187) (RING-type E3 ubiquitin transferase RNF187) |
| Gene Name | RNF187 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8. |
| Sequence (Fasta) | MALPAGPAEA ACALCQRAPR EPVRADCGHR FCRACVVRFW AEEDGPFPCP ECADDCWQRA 60 VEPGRPPLSR RLLALEEAAA APARDGPASE AALQLLCRAD AGPLCAACRM AAGPEPPEWE 120 PRWRKALRGK ENKGSVEIMR KDLNDARDLH GQAESAAAVW KGHVMDRRKK ALTDYKKLRA 180 FFVEEEEHFL QEAEKEEGLP EDELADPTER FRSLLQAVSE LEKKHRNLGL SMLLQ 236 |
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| PTM | Modification Sites |
|---|---|
| Ubiquitination (count: 9) (view all) | 130 WRKALRGKENKGSVE PLMD
133 ALRGKENKGSVEIMR PLMD 161 ESAAAVWKGHVMDRR PLMD 170 HVMDRRKKALTDYKK PLMD 176 KKALTDYKKLRAFFV PLMD 177 KALTDYKKLRAFFVE PLMD |
| Sumoylation (count: 1) | 133 ALRGKENKGSVEIMR PLMD |