Tag | Content |
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UniProt Accession | MSH2_MOUSE; P43247; |
Entrez ID | 17685 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | DNA mismatch repair protein Msh2 (MutS protein homolog 2) |
Gene Name | Msh2 |
Organism | Mus musculus |
NCBI Taxa ID | 10090 |
Functional Description | Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta f(view all) |
Sequence (Fasta) | MAVQPKETLQ LEGAAEAGFV RFFEGMPEKP STTVRLFDRG DFYTAHGEDA LLAAREVFKT 60 QGVIKYMGPA GSKTLQSVVL SKMNFESFVK DLLLVRQYRV EVYKNKAGNK ASKENEWYLA 120 FKASPGNLSQ FEDILFGNND MSASVGVMGI KMAVVDGQRH VGVGYVDSTQ RKLGLCEFPE 180 NDQFSNLEAL LIQIGPKECV LPGGETTGDM GKLRQVIQRG GILITERKRA DFSTKDIYQD 240 LNRLLKGKKG EQINSAALPE MENQVAVSSL SAVIKFLELL SDDSNFGQFE LATFDFSQYM 300 KLDMAAVRAL NLFQGSVEDT TGSQSLAALL NKCKTAQGQR LVNQWIKQPL MDRNRIEERL 360 NLVEAFVEDS ELRQSLQEDL LRRFPDLNRL AKKFQRQAAN LQDCYRLYQG INQLPSVIQA 420 LEKYEGRHQA LLLAVFVTPL IDLRSDFSKF QEMIETTLDM DQVENHEFLV KPSFDPNLSE 480 LREVMDGLEK KMQSTLINAA RGLGLDPGKQ IKLDSSAQFG YYFRVTCKEE KVLRNNKNFS 540 TVDIQKNGVK FTNSELSSLN EEYTKNKGEY EEAQDAIVKE IVNISSGYVE PMQTLNDVLA 600 HLDAIVSFAH VSNAAPVPYV RPVILEKGKG RIILKASRHA CVEVQDEVAF IPNDVHFEKD 660 KQMFHIITGP NMGGKSTYIR QTGVIVLMAQ IGCFVPCESA EVSIVDCILA RVGAGDSQLK 720 GVSTFMAEML ETASILRSAT KDSLIIIDEL GRGTSTYDGF GLAWAISDYI ATKIGAFCMF 780 ATHFHELTAL ANQIPTVNNL HVTALTTEET LTMLYQVKKG VCDQSFGIHV AELANFPRHV 840 IACAKQKALE LEEFQNIGTS LGCDEAEPAA KRRCLEREQG EKIILEFLSK VKQVPFTAMS 900 EESISAKLKQ LKAEVVAKNN SFVNEIISRI KAPAP 936 |
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Database | Annotation |
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CTD (Curated) (count: 6) | MESH:D015179
; Colorectal Neoplasms MESH:D003123 ; Colorectal Neoplasms, Hereditary Nonpolyposis MESH:C537261 ; Lynch syndrome I (site-specific colonic cancer) MESH:D055653 ; Muir-Torre Syndrome MESH:D010051 ; Ovarian Neoplasms MESH:C536928 ; Turcot syndrome |
PTM | Modification Sites |
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Acetylation (count: 3) | 113 KAGNKASKENEWYLA PLMD
567 NEEYTKNKGEYEEAQ PLMD 907 SEESISAKLKQLKAE PLMD |