Tag | Content |
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UniProt Accession | EZH2_HUMAN; Q15910; |
Entrez ID | 2146 |
GenBank Protein ID | NM_001203247.1; NM_001203248.1; NM_001203249.1; NM_004456.4; NM_152998.2; XM_011515884.2; |
GenBank Nucleotide ID | NP_001190176.1; NP_001190177.1; NP_001190178.1; NP_004447.2; NP_694543.1; XP_011514186.1; |
Protein Name | Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.43) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6) |
Gene Name | EZH2; KMT6 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599). Compared to EZH1-containing(view all) |
Sequence (Fasta) | MGQTGKKSEK GPVCWRKRVK SEYMRLRQLK RFRRADEVKS MFSSNRQKIL ERTEILNQEW 60 KQRRIQPVHI LTSVSSLRGT RECSVTSDLD FPTQVIPLKT LNAVASVPIM YSWSPLQQNF 120 MVEDETVLHN IPYMGDEVLD QDGTFIEELI KNYDGKVHGD RECGFINDEI FVELVNALGQ 180 YNDDDDDDDG DDPEEREEKQ KDLEDHRDDK ESRPPRKFPS DKIFEAISSM FPDKGTAEEL 240 KEKYKELTEQ QLPGALPPEC TPNIDGPNAK SVQREQSLHS FHTLFCRRCF KYDCFLHPFH 300 ATPNTYKRKN TETALDNKPC GPQCYQHLEG AKEFAAALTA ERIKTPPKRP GGRRRGRLPN 360 NSSRPSTPTI NVLESKDTDS DREAGTETGG ENNDKEEEEK KDETSSSSEA NSRCQTPIKM 420 KPNIEPPENV EWSGAEASMF RVLIGTYYDN FCAIARLIGT KTCRQVYEFR VKESSIIAPA 480 PAEDVDTPPR KKKRKHRLWA AHCRKIQLKK DGSSNHVYNY QPCDHPRQPC DSSCPCVIAQ 540 NFCEKFCQCS SECQNRFPGC RCKAQCNTKQ CPCYLAVREC DPDLCLTCGA ADHWDSKNVS 600 CKNCSIQRGS KKHLLLAPSD VAGWGIFIKD PVQKNEFISE YCGEIISQDE ADRRGKVYDK 660 YMCSFLFNLN NDFVVDATRK GNKIRFANHS VNPNCYAKVM MVNGDHRIGI FAKRAIQTGE 720 ELFFDYRYSQ ADALKYVGIE REMEIP 747 |
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Database | Annotation |
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Cancer Gene Census | DLBCL |
CTD (Curated) (count: 14) (view all) | MESH:D001943
; Breast Neoplasms MESH:D003398 ; Craniosynostoses MESH:D016889 ; Endometrial Neoplasms MESH:C566025 ; Leukemia, Megakaryoblastic, of Down Syndrome MESH:D054429 ; Leukemia, Myelomonocytic, Juvenile MESH:D008224 ; Lymphoma, Follicular |
DisGeNet (Curated) (count: 127) (view all) | C0001815; Primary Myelofibrosis
C0009081; Congenital clubfoot C0010278; Craniosynostosis C0010417; Cryptorchidism C0010495; Cutis Laxa C0013362; Dysarthria |
GWASdb (count: 1) | rs7783459; Alzheimer's disease; Alzheimer's disease |
PTM | Modification Sites |
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Phosphorylation (count: 32) (view all) | 21 CWRKRVKSEYMRLRQ dbPAF
220 RPPRKFPSDKIFEAI dbPAF 23 RKRVKSEYMRLRQLK dbPAF 292 FCRRCFKYDCFLHPF dbPAF 302 FLHPFHATPNTYKRK dbPAF 339 KEFAAALTAERIKTP dbPAF |
Acetylation (count: 8) (view all) | 10 QTGKKSEKGPVCWRK PLMD
234 ISSMFPDKGTAEELK PLMD 241 KGTAEELKEKYKELT PLMD 318 TETALDNKPCGPQCY PLMD 569 CKAQCNTKQCPCYLA PLMD 698 VNPNCYAKVMMVNGD PLMD |
Ubiquitination (count: 15) (view all) | 10 QTGKKSEKGPVCWRK PLMD
217 KESRPPRKFPSDKIF PLMD 245 EELKEKYKELTEQQL PLMD 39 FRRADEVKSMFSSNR PLMD 461 IARLIGTKTCRQVYE PLMD 472 QVYEFRVKESSIIAP PLMD |
Methylation (count: 4) | 505 LWAAHCRKIQLKKDG PLMD
509 HCRKIQLKKDGSSNH PLMD 510 CRKIQLKKDGSSNHV PLMD 735 YSQADALKYVGIERE PLMD |
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