| Tag | Content |
|---|---|
| UniProt Accession | H33_HUMAN; P84243; |
| Entrez ID | 3020 |
| GenBank Protein ID | NM_002107.4; NM_005324.4; |
| GenBank Nucleotide ID | NP_002098.1; NP_005315.1; |
| Protein Name | Histone H3.3 |
| Gene Name | H3F3A; H3.3A; H3F3; PP781;; H3F3B; H3.3B |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Sequence (Fasta) | MARTKQTARK STGGKAPRKQ LATKAARKSA PSTGGVKKPH RYRPGTVALR EIRRYQKSTE 60 LLIRKLPFQR LVREIAQDFK TDLRFQSAAI GALQEASEAY LVGLFEDTNL CAIHAKRVTI 120 MPKDIQLARR IRGERA 137 |
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Database | Annotation |
|---|---|
| Cancer Gene Census | glioma |
| CTD (Curated) (count: 3) | MESH:D018212
; Giant Cell Tumor of Bone MESH:D005909 ; Glioblastoma MESH:D005910 ; Glioma |
| DisGeNet (Curated) (count: 3) | C0017636; Glioblastoma
C0017638; Glioma C0206638; Giant Cell Tumor of Bone |
| GWASdb (count: 1) | rs6664668; Alcohol and nictotine co-dependence; alcohol dependence|nicotine dependence |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 15) (view all) | 100 LQEASEAYLVGLFED dbPAF
108 LVGLFEDTNLCAIHA dbPAF 11 TKQTARKSTGGKAPR dbPAF 12 KQTARKSTGGKAPRK dbPAF 29 ATKAARKSAPSTGGV dbPAF 32 AARKSAPSTGGVKKP dbPAF |
| Acetylation (count: 3) | 28 LATKAARKSAPSTGG PLMD
37 APSTGGVKKPHRYRP PLMD 38 PSTGGVKKPHRYRPG PLMD |
| Ubiquitination (count: 3) | 28 LATKAARKSAPSTGG PLMD
37 APSTGGVKKPHRYRP PLMD 38 PSTGGVKKPHRYRPG PLMD |
| Sumoylation (count: 2) | 24 PRKQLATKAARKSAP PLMD
80 REIAQDFKTDLRFQS PLMD |
| Butyrylation (count: 1) | 28 LATKAARKSAPSTGG PLMD |
| Crotonylation (count: 6) | 10 RTKQTARKSTGGKAP PLMD
19 TGGKAPRKQLATKAA PLMD 24 PRKQLATKAARKSAP PLMD 28 LATKAARKSAPSTGG PLMD 5 ***MARTKQTARKST PLMD 57 REIRRYQKSTELLIR PLMD |
| Methylation (count: 3) | 28 LATKAARKSAPSTGG PLMD
37 APSTGGVKKPHRYRP PLMD 38 PSTGGVKKPHRYRPG PLMD |