| Tag | Content |
|---|---|
| UniProt Accession | EED_HUMAN; O75530; |
| Entrez ID | 8726 |
| GenBank Protein ID | NM_001308007.1; NM_003797.4; |
| GenBank Nucleotide ID | NP_001294936.1; NP_003788.2; |
| Protein Name | Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1) |
| Gene Name | EED |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. |
| Sequence (Fasta) | MSEREVSTAP AGTDMPAAKK QKLSSDENSN PDLSGDENDD AVSIESGTNT ERPDTPTNTP 60 NAPGRKSWGK GKWKSKKCKY SFKCVNSLKE DHNQPLFGVQ FNWHSKEGDP LVFATVGSNR 120 VTLYECHSQG EIRLLQSYVD ADADENFYTC AWTYDSNTSH PLLAVAGSRG IIRIINPITM 180 QCIKHYVGHG NAINELKFHP RDPNLLLSVS KDHALRLWNI QTDTLVAIFG GVEGHRDEVL 240 SADYDLLGEK IMSCGMDHSL KLWRINSKRM MNAIKESYDY NPNKTNRPFI SQKIHFPDFS 300 TRDIHRNYVD CVRWLGDLIL SKSCENAIVC WKPGKMEDDI DKIKPSESNV TILGRFDYSQ 360 CDIWYMRFSM DFWQKMLALG NQVGKLYVWD LEVEDPHKAK CTTLTHHKCG AAIRQTSFSR 420 DSSILIAVCD DASIWRWDRL R 442 |
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| Database | Annotation |
|---|---|
| Cancer Gene Census | malignant peripheral nerve sheath tumours, MDS and related, lung adenocarcinoma |
| CTD (Curated) (count: 2) | MESH:D018317
; Nerve Sheath Neoplasms MESH:D009442 ; Neurilemmoma |
| GWASdb (count: 3) | rs991435; Cholesterol; arteriosclerosis|coronary artery disease|lipid metabolism disorder
rs7951030; Cholesterol; arteriosclerosis|coronary artery disease|lipid metabolism disorder rs10792844; Ovarian cancer; ovarian cancer |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 17) (view all) | 115 GDPLVFATVGSNRVT dbPAF
118 LVFATVGSNRVTLYE dbPAF 2 ******MSEREVSTA dbPAF 24 AAKKQKLSSDENSNP dbPAF 25 AKKQKLSSDENSNPD dbPAF 277 MMNAIKESYDYNPNK dbPAF |
| Acetylation (count: 6) | 19 GTDMPAAKKQKLSSD PLMD
211 NLLLSVSKDHALRLW PLMD 293 NRPFISQKIHFPDFS PLMD 332 ENAIVCWKPGKMEDD PLMD 398 LEVEDPHKAKCTTLT PLMD 83 KKCKYSFKCVNSLKE PLMD |
| Ubiquitination (count: 7) (view all) | 19 GTDMPAAKKQKLSSD PLMD
197 GNAINELKFHPRDPN PLMD 211 NLLLSVSKDHALRLW PLMD 275 KRMMNAIKESYDYNP PLMD 284 SYDYNPNKTNRPFIS PLMD 344 EDDIDKIKPSESNVT PLMD |
| Network | Interaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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