Q9UKU9

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession ANGL2_HUMAN; Q9UKU9;
Entrez ID 23452
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Angiopoietin-related protein 2 (Angiopoietin-like protein 2)
Gene Name ANGPTL2; ARP2; UNQ170/PRO196
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionInduces sprouting in endothelial cells through an autocrine and paracrine action.
Sequence
(Fasta)		MRPLCVTCWW LGLLAAMGAV AGQEDGFEGT EEGSPREFIY LNRYKRAGES QDKCTYTFIV 60
PQQRVTGAIC VNSKEPEVLL ENRVHKQELE LLNNELLKQK RQIETLQQLV EVDGGIVSEV 120
KLLRKESRNM NSRVTQLYMQ LLHEIIRKRD NALELSQLEN RILNQTADML QLASKYKDLE 180
HKYQHLATLA HNQSEIIAQL EEHCQRVPSA RPVPQPPPAA PPRVYQPPTY NRIINQISTN 240
EIQSDQNLKV LPPPLPTMPT LTSLPSSTDK PSGPWRDCLQ ALEDGHDTSS IYLVKPENTN 300
RLMQVWCDQR HDPGGWTVIQ RRLDGSVNFF RNWETYKQGF GNIDGEYWLG LENIYWLTNQ 360
GNYKLLVTME DWSGRKVFAE YASFRLEPES EYYKLRLGRY HGNAGDSFTW HNGKQFTTLD 420
RDHDVYTGNC AHYQKGGWWY NACAHSNLNG VWYRGGHYRS RYQDGVYWAE FRGGSYSLKK 480
VVMMIRPNPN TFH 494

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1MethylationCarcinomaA24258150
[Reference]: These results suggest that UV exposure induces ANGPTL2 expression, leading to decreases MSH2 levels in human skin tissues.

※ Disease Cross-ref Annotation

DatabaseAnnotation
GWASdb
(count: 1)		rs2297866; Serum metabolites; Null

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 3)		 426       LDRDHDVYTGNCAHY     dbPAF
433       YTGNCAHYQKGGWWY     dbPAF
476       AEFRGGSYSLKKVVM     dbPAF
Methylation
(count: 1)		 86        LLENRVHKQELELLN     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource