| Tag | Content |
|---|---|
| UniProt Accession | KDM1A_HUMAN; O60341; |
| Entrez ID | 23028 |
| GenBank Protein ID | NM_001009999.2; NM_015013.3; |
| GenBank Nucleotide ID | NP_001009999.1; NP_055828.2; |
| Protein Name | Lysine-specific histone demethylase 1A (EC 1.-.-.-) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) |
| Gene Name | KDM1A; AOF2; KDM1; KIAA0601; LSD1 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demeth(view all) |
| Sequence (Fasta) | MLSGKKAAAA AAAAAAAATG TEAGPGTAGG SENGSEVAAQ PAGLSGPAEV GPGAVGERTP 60 RKKEPPRASP PGGLAEPPGS AGPQAGPTVV PGSATPMETG IAETPEGRRT SRRKRAKVEY 120 REMDESLANL SEDEYYSEEE RNAKAEKEKK LPPPPPQAPP EEENESEPEE PSGVEGAAFQ 180 SRLPHDRMTS QEAACFPDII SGPQQTQKVF LFIRNRTLQL WLDNPKIQLT FEATLQQLEA 240 PYNSDTVLVH RVHSYLERHG LINFGIYKRI KPLPTKKTGK VIIIGSGVSG LAAARQLQSF 300 GMDVTLLEAR DRVGGRVATF RKGNYVADLG AMVVTGLGGN PMAVVSKQVN MELAKIKQKC 360 PLYEANGQAV PKEKDEMVEQ EFNRLLEATS YLSHQLDFNV LNNKPVSLGQ ALEVVIQLQE 420 KHVKDEQIEH WKKIVKTQEE LKELLNKMVN LKEKIKELHQ QYKEASEVKP PRDITAEFLV 480 KSKHRDLTAL CKEYDELAET QGKLEEKLQE LEANPPSDVY LSSRDRQILD WHFANLEFAN 540 ATPLSTLSLK HWDQDDDFEF TGSHLTVRNG YSCVPVALAE GLDIKLNTAV RQVRYTASGC 600 EVIAVNTRST SQTFIYKCDA VLCTLPLGVL KQQPPAVQFV PPLPEWKTSA VQRMGFGNLN 660 KVVLCFDRVF WDPSVNLFGH VGSTTASRGE LFLFWNLYKA PILLALVAGE AAGIMENISD 720 DVIVGRCLAI LKGIFGSSAV PQPKETVVSR WRADPWARGS YSYVAAGSSG NDYDLMAQPI 780 TPGPSIPGAP QPIPRLFFAG EHTIRNYPAT VHGALLSGLR EAGRIADQFL GAMYTLPRQA 840 TPGVPAQQSP SM 853 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 7) (view all) | OMIM:616728
; CLEFT PALATE, PSYCHOMOTOR RETARDATION, AND DISTINCTIVE FACIAL FEATURES MESH:D003110 ; Colonic Neoplasms MESH:D016638 ; Critical Illness MESH:D018450 ; Disease Progression MESH:D006965 ; Hyperplasia MESH:D009361 ; Neoplasm Invasiveness |
| DisGeNet (Curated) (count: 5) | C0007131; Non-Small Cell Lung Carcinoma
C0009375; Colonic Neoplasms C0020507; Hyperplasia C0027626; Neoplasm Invasiveness C4225229; CLEFT PALATE, PSYCHOMOTOR RETARDATION, AND DISTINCTIVE FACIAL FEATURES |
| GWASdb (count: 3) | rs587168; Oral cancers (chewing tobacco related); squamous cell carcinoma|mouth disease
rs5027299; Multiple complex diseases; Null rs5027299; Response to platinum-based chemotherapy in small cell and non-small cell lung cancers; non-small cell lung carcinoma|lung small cell carcinoma |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 27) (view all) | 104 METGIAETPEGRRTS dbPAF
111 TPEGRRTSRRKRAKV dbPAF 126 EYREMDESLANLSED dbPAF 131 DESLANLSEDEYYSE dbPAF 135 ANLSEDEYYSEEERN dbPAF 136 NLSEDEYYSEEERNA dbPAF |
| Acetylation (count: 5) | 268 LINFGIYKRIKPLPT PLMD
276 RIKPLPTKKTGKVII PLMD 355 QVNMELAKIKQKCPL PLMD 503 ELAETQGKLEEKLQE PLMD 732 GRCLAILKGIFGSSA PLMD |
| Ubiquitination (count: 32) (view all) | 268 LINFGIYKRIKPLPT PLMD
276 RIKPLPTKKTGKVII PLMD 277 IKPLPTKKTGKVIII PLMD 280 LPTKKTGKVIIIGSG PLMD 322 GRVATFRKGNYVADL PLMD 355 QVNMELAKIKQKCPL PLMD |
| Sumoylation (count: 3) | 117 TSRRKRAKVEYREMD PLMD
424 QLQEKHVKDEQIEHW PLMD 442 VKTQEELKELLNKMV PLMD |
| Methylation (count: 2) | 114 GRRTSRRKRAKVEYR PLMD
322 GRVATFRKGNYVADL PLMD |
| Network | Interaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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