| Tag | Content |
|---|---|
| UniProt Accession | ABCG2_HUMAN; Q9UNQ0; |
| Entrez ID | 9429 |
| GenBank Protein ID | NM_001257386.1; NM_004827.2; XM_005263355.3; XM_011532420.2; |
| GenBank Nucleotide ID | NP_001244315.1; NP_004818.2; XP_005263412.1; XP_011530722.1; |
| Protein Name | ATP-binding cassette sub-family G member 2 (Breast cancer resistance protein) (CDw338) (Mitoxantrone resistance-associated protein) (Placenta-specific ATP-binding cassette transporter) (Urate exporter) (CD antigen CD338) |
| Gene Name | ABCG2; ABCP; BCRP; BCRP1; MXR |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin. |
| Sequence (Fasta) | MSSSNVEVFI PVSQGNTNGF PATASNDLKA FTEGAVLSFH NICYRVKLKS GFLPCRKPVE 60 KEILSNINGI MKPGLNAILG PTGGGKSSLL DVLAARKDPS GLSGDVLING APRPANFKCN 120 SGYVVQDDVV MGTLTVRENL QFSAALRLAT TMTNHEKNER INRVIQELGL DKVADSKVGT 180 QFIRGVSGGE RKRTSIGMEL ITDPSILFLD EPTTGLDSST ANAVLLLLKR MSKQGRTIIF 240 SIHQPRYSIF KLFDSLTLLA SGRLMFHGPA QEALGYFESA GYHCEAYNNP ADFFLDIING 300 DSTAVALNRE EDFKATEIIE PSKQDKPLIE KLAEIYVNSS FYKETKAELH QLSGGEKKKK 360 ITVFKEISYT TSFCHQLRWV SKRSFKNLLG NPQASIAQII VTVVLGLVIG AIYFGLKNDS 420 TGIQNRAGVL FFLTTNQCFS SVSAVELFVV EKKLFIHEYI SGYYRVSSYF LGKLLSDLLP 480 MRMLPSIIFT CIVYFMLGLK PKADAFFVMM FTLMMVAYSA SSMALAIAAG QSVVSVATLL 540 MTICFVFMMI FSGLLVNLTT IASWLSWLQY FSIPRYGFTA LQHNEFLGQN FCPGLNATGN 600 NPCNYATCTG EEYLVKQGID LSPWGLWKNH VALACMIVIF LTIAYLKLLF LKKYS 656 |
|
||||||||||||||||||||
| Database | Annotation |
|---|---|
| CTD (Curated) (count: 14) (view all) | MESH:D000236
; Adenoma MESH:D001172 ; Arthritis, Rheumatoid MESH:D001943 ; Breast Neoplasms MESH:C535575 ; Carcinoma, squamous cell of head and neck MESH:D015179 ; Colorectal Neoplasms MESH:D064420 ; Drug-Related Side Effects and Adverse Reactions |
| HGMD (count: 15) (view all) | CD057478; Breast cancer resistance protein deficiency, association with; Small deletions
CM045703; Reduced ATPase activity, association with; Missense/nonsense CM057427; Breast cancer resistance protein deficiency, association with; Missense/nonsense CM057428; Gout, association with; Missense/nonsense CM057861; Reduced protein expression, association with; Missense/nonsense CM075963; Breast cancer resistance protein deficiency, association with; Missense/nonsense |
| GWASdb (count: 116) (view all) | rs2231164; Urate levels; gout
rs2231156; Uric acid levels; gout rs2231156; Urate levels; gout rs4148157; Uric acid levels; gout rs4148157; Urate levels; gout rs4693924; Uric acid levels; gout |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 13) (view all) | 100 LAARKDPSGLSGDVL dbPAF
103 RKDPSGLSGDVLING dbPAF 143 VRENLQFSAALRLAT dbPAF 153 LRLATTMTNHEKNER dbPAF 187 TQFIRGVSGGERKRT dbPAF 194 SGGERKRTSIGMELI dbPAF |
| Acetylation (count: 1) | 172 IQELGLDKVADSKVG PLMD |
| Ubiquitination (count: 13) (view all) | 172 IQELGLDKVADSKVG PLMD
177 LDKVADSKVGTQFIR PLMD 314 LNREEDFKATEIIEP PLMD 323 TEIIEPSKQDKPLIE PLMD 326 IEPSKQDKPLIEKLA PLMD 331 QDKPLIEKLAEIYVN PLMD |
| Glycation (count: 1) | 72 SNINGIMKPGLNAIL PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |