| Tag | Content |
|---|---|
| UniProt Accession | MK10_HUMAN; P53779; |
| Entrez ID | 5602 |
| GenBank Protein ID | NM_001318067.1; NM_001318068.1; NM_001318069.1; NM_002753.4; NM_138980.3; NM_138982.3; XM_005263129.2; XM_005263130.2; XM_005263135.3; XM_006714268.2; XM_011532117.2; XM_011532118.2; XM_011532120.2; XM_011532121.2; XM_017008419.1; XM_017008420.1; XM_017008421.1; XM_017008423.1; XM_017008424.1; XM_017008425.1; XM_017008426.1; XM_017008429.1; XM_017008430.1; XM_017008431.1; XM_017008432.1; |
| GenBank Nucleotide ID | NP_001304996.1; NP_001304997.1; NP_001304998.1; NP_002744.1; NP_620446.1; NP_620448.1; XP_005263186.1; XP_005263187.1; XP_005263192.1; XP_006714331.1; XP_011530419.1; XP_011530420.1; XP_011530422.1; XP_011530423.1; XP_016863908.1; XP_016863909.1; XP_016863910.1; XP_016863912.1; XP_016863913.1; XP_016863914.1; XP_016863915.1; XP_016863918.1; XP_016863919.1; XP_016863920.1; XP_016863921.1; |
| Protein Name | Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) |
| Gene Name | MAPK10; JNK3; JNK3A; PRKM10; SAPK1B |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). |
| Sequence (Fasta) | MSLHFLYYCS EPTLDVKIAF CQGFDKQVDV SYIAKHYNMS KSKVDNQFYS VEVGDSTFTV 60 LKRYQNLKPI GSGAQGIVCA AYDAVLDRNV AIKKLSRPFQ NQTHAKRAYR ELVLMKCVNH 120 KNIISLLNVF TPQKTLEEFQ DVYLVMELMD ANLCQVIQME LDHERMSYLL YQMLCGIKHL 180 HSAGIIHRDL KPSNIVVKSD CTLKILDFGL ARTAGTSFMM TPYVVTRYYR APEVILGMGY 240 KENVDIWSVG CIMGEMVRHK ILFPGRDYID QWNKVIEQLG TPCPEFMKKL QPTVRNYVEN 300 RPKYAGLTFP KLFPDSLFPA DSEHNKLKAS QARDLLSKML VIDPAKRISV DDALQHPYIN 360 VWYDPAEVEA PPPQIYDKQL DEREHTIEEW KELIYKEVMN SEEKTKNGVV KGQPSPSGAA 420 VNSSESLPPS SSVNDISSMS TDQTLASDTD SSLEASAGPL GCCR 465 |
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| Database | Annotation |
|---|---|
| HGMD (count: 1) | CP060736; Epileptic encephalopathy; Complex rearrangements
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| GWASdb (count: 39) (view all) | rs2575675; Response to cytidine analogues (gemcitabine); cancer
rs7699978; Response to cytidine analogues (gemcitabine); cancer rs6810413; Major depressive disorder; major depressive disorder rs10028075; Bipolar disorder; bipolar disorder rs10028075; Major depressive disorder; major depressive disorder rs3775180; Multiple complex diseases; Null |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 8) (view all) | 131 ISLLNVFTPQKTLEE dbPAF
216 GLARTAGTSFMMTPY dbPAF 217 LARTAGTSFMMTPYV dbPAF 221 AGTSFMMTPYVVTRY dbPAF 223 TSFMMTPYVVTRYYR dbPAF 226 MMTPYVVTRYYRAPE dbPAF |
| Ubiquitination (count: 1) | 289 PCPEFMKKLQPTVRN PLMD |
| Network | Interaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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