| Tag | Content |
|---|---|
| UniProt Accession | KDM4C_HUMAN; Q9H3R0; |
| Entrez ID | 23081 |
| GenBank Protein ID | NM_001146695.1; NM_001146696.1; NM_015061.3; |
| GenBank Nucleotide ID | NP_001140167.1; NP_001140168.1; NP_055876.2; |
| Protein Name | Lysine-specific demethylase 4C (EC 1.14.11.-) (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein) (JmjC domain-containing histone demethylation protein 3C) (Jumonji domain-containing protein 2C) |
| Gene Name | KDM4C; GASC1; JHDM3C; JMJD2C; KIAA0780 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. |
| Sequence (Fasta) | MEVAEVESPL NPSCKIMTFR PSMEEFREFN KYLAYMESKG AHRAGLAKVI PPKEWKPRQC 60 YDDIDNLLIP APIQQMVTGQ SGLFTQYNIQ KKAMTVKEFR QLANSGKYCT PRYLDYEDLE 120 RKYWKNLTFV APIYGADING SIYDEGVDEW NIARLNTVLD VVEEECGISI EGVNTPYLYF 180 GMWKTTFAWH TEDMDLYSIN YLHFGEPKSW YAIPPEHGKR LERLAQGFFP SSSQGCDAFL 240 RHKMTLISPS VLKKYGIPFD KITQEAGEFM ITFPYGYHAG FNHGFNCAES TNFATVRWID 300 YGKVAKLCTC RKDMVKISMD IFVRKFQPDR YQLWKQGKDI YTIDHTKPTP ASTPEVKAWL 360 QRRRKVRKAS RSFQCARSTS KRPKADEEEE VSDEVDGAEV PNPDSVTDDL KVSEKSEAAV 420 KLRNTEASSE EESSASRMQV EQNLSDHIKL SGNSCLSTSV TEDIKTEDDK AYAYRSVPSI 480 SSEADDSIPL SSGYEKPEKS DPSELSWPKS PESCSSVAES NGVLTEGEES DVESHGNGLE 540 PGEIPAVPSG ERNSFKVPSI AEGENKTSKS WRHPLSRPPA RSPMTLVKQQ APSDEELPEV 600 LSIEEEVEET ESWAKPLIHL WQTKSPNFAA EQEYNATVAR MKPHCAICTL LMPYHKPDSS 660 NEENDARWET KLDEVVTSEG KTKPLIPEMC FIYSEENIEY SPPNAFLEED GTSLLISCAK 720 CCVRVHASCY GIPSHEICDG WLCARCKRNA WTAECCLCNL RGGALKQTKN NKWAHVMCAV 780 AVPEVRFTNV PERTQIDVGR IPLQRLKLKC IFCRHRVKRV SGACIQCSYG RCPASFHVTC 840 AHAAGVLMEP DDWPYVVNIT CFRHKVNPNV KSKACEKVIS VGQTVITKHR NTRYYSCRVM 900 AVTSQTFYEV MFDDGSFSRD TFPEDIVSRD CLKLGPPAEG EVVQVKWPDG KLYGAKYFGS 960 NIAHMYQVEF EDGSQIAMKR EDIYTLDEEL PKRVKARFST ASDMRFEDTF YGADIIQGER 1020 KRQRVLSSRF KNEYVADPVY RTFLKSSFQK KCQKRQ 1057 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 1) | MESH:D008527 ; Medulloblastoma |
| DisGeNet (Curated) (count: 2) | C0025149; Medulloblastoma
C0236663; Alcohol withdrawal syndrome |
| HGMD (count: 1) | CM091846; Upper aerodigestive tract cancer, association with; Missense/nonsense
|
| GWASdb (count: 111) (view all) | rs2990659; Bipolar disorder and schizophrenia; bipolar disorder|schizophrenia
rs4742247; Acute lung injury; lung disease rs2988414; Acute lymphoblastic leukemia (childhood); acute lymphocytic leukemia|acute leukemia rs2988414; Bipolar disorder and schizophrenia; bipolar disorder|schizophrenia rs7036872; Smoking cessation; nicotine dependence rs12346963; Suicide attempts in bipolar disorder; bipolar disorder |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 21) (view all) | 1009 SDMRFEDTFYGADII dbPAF
245 AFLRHKMTLISPSVL dbPAF 248 RHKMTLISPSVLKKY dbPAF 250 KMTLISPSVLKKYGI dbPAF 353 TKPTPASTPEVKAWL dbPAF 392 ADEEEEVSDEVDGAE dbPAF |
| Ubiquitination (count: 9) (view all) | 254 ISPSVLKKYGIPFDK PLMD
303 VRWIDYGKVAKLCTC PLMD 31 EEFREFNKYLAYMES PLMD 338 YQLWKQGKDIYTIDH PLMD 809 PLQRLKLKCIFCRHR PLMD 933 IVSRDCLKLGPPAEG PLMD |
| Sumoylation (count: 1) | 1031 RVLSSRFKNEYVADP PLMD |
| Glycation (count: 1) | 253 LISPSVLKKYGIPFD PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |