Q2TAM9

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession TUSC1_HUMAN; Q2TAM9;
Entrez ID 286319
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Tumor suppressor candidate gene 1 protein (TSG-9) (TSG9)
Gene Name TUSC1
Organism Homo sapiens
NCBI Taxa ID 9606
Sequence
(Fasta)		MGPMWRMRGG ATRRGSCCGG DGAADGRGPG RSGRARGGGS PSGGGGGVGW RGRADGARQQ 60
LEERFADLAA SHLEAIRARD EWDRQNARLR QENARLRLEN RRLKRENRSL FRQALRLPGE 120
GGNGTPAEAR RVPEEASTNR RARDSGREDE PGSPRALRAR LEKLEAMYRR ALLQLHLEQR 180
GPRPSGDKEE QPLQEPDSGL RSRDSEPSGP WL 213

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1MethylationHepatocellular carcinoma/Hepatocarcinoma/HepatomaD24366000
[Reference]: The TUSC1 protein expression pattern in HCC and liver tissues was consistent with TUSC1 mRNA expression Our results suggest that TUSC1 is a candidate tumor suppressor gene and intragenic hypermethylation is one of the suppressive mechanisms that regulate TUSC1 transcription in HCC. Intragenic methylation of the TUSC1 gene may serve as a novel prognostic marker of HCC.

※ Disease Cross-ref Annotation

DatabaseAnnotation
GWASdb
(count: 4)		rs1128957; Height; Null
rs1128957; Multiple complex diseases; Null
rs10738727; Height; Null
rs10738727; Multiple complex diseases; Null

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 2)		 145       TNRRARDSGREDEPG     dbPAF
153       GREDEPGSPRALRAR     dbPAF