| Tag | Content |
|---|---|
| UniProt Accession | MLH1_HUMAN; P40692; |
| Entrez ID | 4292 |
| GenBank Protein ID | NM_000249.3; NM_001167617.1; NM_001167618.1; NM_001167619.1; NM_001258271.1; NM_001258273.1; NM_001258274.1; XM_005265163.1; XM_005265164.1; |
| GenBank Nucleotide ID | NP_000240.1; NP_001161089.1; NP_001161090.1; NP_001161091.1; NP_001245200.1; NP_001245202.1; NP_001245203.1; XP_005265220.1; XP_005265221.1; |
| Protein Name | DNA mismatch repair protein Mlh1 (MutL protein homolog 1) |
| Gene Name | MLH1; COCA2 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand cont(view all)Functional Description Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis. |
| Sequence (Fasta) | MSFVAGVIRR LDETVVNRIA AGEVIQRPAN AIKEMIENCL DAKSTSIQVI VKEGGLKLIQ 60 IQDNGTGIRK EDLDIVCERF TTSKLQSFED LASISTYGFR GEALASISHV AHVTITTKTA 120 DGKCAYRASY SDGKLKAPPK PCAGNQGTQI TVEDLFYNIA TRRKALKNPS EEYGKILEVV 180 GRYSVHNAGI SFSVKKQGET VADVRTLPNA STVDNIRSIF GNAVSRELIE IGCEDKTLAF 240 KMNGYISNAN YSVKKCIFLL FINHRLVEST SLRKAIETVY AAYLPKNTHP FLYLSLEISP 300 QNVDVNVHPT KHEVHFLHEE SILERVQQHI ESKLLGSNSS RMYFTQTLLP GLAGPSGEMV 360 KSTTSLTSSS TSGSSDKVYA HQMVRTDSRE QKLDAFLQPL SKPLSSQPQA IVTEDKTDIS 420 SGRARQQDEE MLELPAPAEV AAKNQSLEGD TTKGTSEMSE KRGPTSSNPR KRHREDSDVE 480 MVEDDSRKEM TAACTPRRRI INLTSVLSLQ EEINEQGHEV LREMLHNHSF VGCVNPQWAL 540 AQHQTKLYLL NTTKLSEELF YQILIYDFAN FGVLRLSEPA PLFDLAMLAL DSPESGWTEE 600 DGPKEGLAEY IVEFLKKKAE MLADYFSLEI DEEGNLIGLP LLIDNYVPPL EGLPIFILRL 660 ATEVNWDEEK ECFESLSKEC AMFYSIRKQY ISEESTLSGQ QSEVPGSIPN SWKWTVEHIV 720 YKALRSHILP PKHFTEDGNI LQLANLPDLY KVFERC 757 Fasta Sequence>P40692|MLH1; COCA2|Homo sapiens (Human) MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC |
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| Database | Annotation |
|---|---|
| Cancer Gene Census | colorectal, endometrial, ovarian, CNS tumours colorectal, endometrial, ovarian, CNS hereditary non-polyposis colorectal cancer, Turcot syndrome |
| CTD (Curated) (count: 10) (view all) | MESH:D003110
; Colonic Neoplasms MESH:D015179 ; Colorectal Neoplasms MESH:D003123 ; Colorectal Neoplasms, Hereditary Nonpolyposis MESH:D008223 ; Lymphoma MESH:D055847 ; Lynch Syndrome II MESH:D055653 ; Muir-Torre Syndrome MESH:D009362
; Neoplasm Metastasis MESH:D010051 ; Ovarian Neoplasms MESH:D011471 ; Prostatic Neoplasms MESH:C536928 ; Turcot syndrome |
| DisGeNet (Curated) (count: 67) (view all) | C0000737; Abdominal Pain
C0003467; Anxiety C0007102; Malignant tumor of colon C0007117; Basal cell carcinoma C0009375; Colonic Neoplasms C0009404; Colorectal Neoplasms C0009405; Hereditary Nonpolyposis Colorectal Neoplasms
C0009806; Constipation C0011581; Depressive disorder C0012811; Colon diverticulum anatomic structure C0012819; Diverticular disease of colon C0014474; Ependymoma C0014544; Epilepsy C0015672; Fatigue C0017181; Gastrointestinal Hemorrhage C0017636; Glioblastoma C0023418; leukemia C0024299; Lymphoma C0025149; Medulloblastoma C0026826; Muscle Hypertonia C0026827; Muscle hypotonia C0027498; Nausea and vomiting C0027627; Neoplasm Metastasis C0027819; Neuroblastoma C0033578; Prostatic Neoplasms C0034885; Rectal Neoplasms C0035412; Rhabdomyosarcoma C0036572; Seizures C0038356; Stomach Neoplasms C0149931; Migraine Disorders C0151740; Intracranial Hypertension C0206684; Sebaceous Adenocarcinoma C0221263; Cafe-au-Lait Spots C0237326; Dyschezia C0265319; Fibrous skin tumor of tuberous sclerosis C0265325; Turcot syndrome (disorder) C0265974; Birthmark C0278804; Adenocarcinoma of duodenum C0376545; Hematologic Neoplasms C0497538; Benign digestive system neoplasms C0541912; Duodenal Cancer C0595989; Carcinoma of larynx C0678222; Breast Carcinoma C0744641; Intermittent migraine headaches C0919267; ovarian neoplasm C1262477; Weight decreased C1263846; Attention deficit hyperactivity disorder C1321489; Torre-Muir syndrome C1333990; Hereditary Nonpolyposis Colorectal Cancer C1333991; Hereditary Non-Polyposis Colon Cancer Type 2 C1368816; Sebaceous adenoma C1527249; Colorectal Cancer C1834728; Malignant genitourinary tract tumors C1842774; Hyperpigmented macules C1844947; Death in early childhood C1858430; Death in infancy C1860335; Axillary freckling C1861975; Cafe au lait spots, multiple C1862314; Basal cell nevi C2700617; Irritation - emotion C3714745; Malabsorption C3804991; Benign genitourinary tract neoplasm C4020813; Increased gastric cancer C4020869; Abnormality of the abdomen C4020884; Anxiety disease C4020899; Autosomal recessive predisposition C4022012; Death in early adulthood |
| HGMD (count: 713) (view all) | CP053740; Colorectal cancer, non-polyposis; Complex rearrangements
CP064923; Colorectal cancer ?; Complex rearrangements CP064924; Colorectal cancer, non-polyposis; Complex rearrangements CP065943; Colorectal cancer; Complex rearrangements CP035450; Colorectal cancer, non-polyposis; Complex rearrangements CP061621; Colorectal cancer, non-polyposis; Complex rearrangements CD011632; Colorectal cancer, non-polyposis; Small deletions
CD092656; Colorectal cancer, non-polyposis; Small deletions CD066373; Colorectal cancer; Small deletions CD991796; Colorectal cancer, non-polyposis; Small deletions CD024050; Colorectal cancer, non-polyposis; Small deletions CD092655; Colorectal cancer, non-polyposis; Small deletions CD040909; Colorectal cancer, non-polyposis; Small deletions CD056170; Colorectal cancer, non-polyposis; Small deletions CD033543; Colorectal cancer, non-polyposis; Small deletions CD951779; Colorectal cancer, non-polyposis; Small deletions CD021429; Colorectal cancer, non-polyposis; Small deletions CD994011; Colorectal cancer, non-polyposis; Small deletions CD042873; Colorectal cancer, non-polyposis; Small deletions CD982792; Colorectal cancer, non-polyposis; Small deletions CD011630; Colorectal cancer, non-polyposis; Small deletions CD085022; Colorectal cancer, non-polyposis; Small deletions CD031062; Colorectal cancer, non-polyposis; Small deletions CD044149; Colorectal cancer, non-polyposis; Small deletions CD087016; Colorectal cancer, non-polyposis; Small deletions CD015054; Colorectal cancer, non-polyposis; Small deletions CD044148; Colorectal cancer, non-polyposis; Small deletions CD991795; Colorectal cancer, non-polyposis; Small deletions CD056171; Colorectal cancer, non-polyposis; Small deletions CD032122; Colorectal cancer, non-polyposis; Small deletions CD056172; Colorectal cancer, non-polyposis; Small deletions CD042609; Colorectal cancer, non-polyposis; Small deletions CD983840; Colorectal cancer, non-polyposis; Small deletions CD962075; Colorectal cancer, non-polyposis; Small deletions CD962074; Colorectal cancer, non-polyposis; Small deletions CD033204; Colorectal cancer, non-polyposis; Small deletions CD982794; Muir-Torre syndrome; Small deletions CD056173; Colorectal cancer, non-polyposis; Small deletions CD033544; Colorectal cancer, non-polyposis; Small deletions CD951777; Colorectal cancer, non-polyposis; Small deletions CD016091; Colorectal cancer, non-polyposis; Small deletions CD056174; Colorectal cancer, non-polyposis; Small deletions CD057523; Colorectal cancer, non-polyposis; Small deletions CD042874; Colorectal cancer, non-polyposis; Small deletions CD055711; Colorectal cancer, non-polyposis; Small deletions CD011628; Colorectal cancer, non-polyposis; Small deletions CD064577; Colorectal cancer, non-polyposis; Small deletions CD067181; Colorectal cancer, non-polyposis; Small deletions CD057808; Colorectal cancer, non-polyposis ?; Small deletions CD962069; Colorectal cancer, non-polyposis; Small deletions CD032125; Colorectal cancer, non-polyposis; Small deletions CD022902; Colorectal cancer, non-polyposis; Small deletions CD093528; Colorectal cancer, non-polyposis; Small deletions CD023714; Colorectal cancer, non-polyposis; Small deletions CD023713; Colorectal cancer, non-polyposis; Small deletions CD066374; Colorectal cancer, non-polyposis; Small deletions CD075468; Colorectal cancer, non-polyposis; Small deletions CD022284; Colorectal cancer, non-polyposis; Small deletions CD011633; Colorectal cancer, non-polyposis; Small deletions CD043954; Colorectal cancer, non-polyposis; Small deletions CD023523; Colorectal cancer, non-polyposis; Small deletions CD994094; Colorectal cancer, non-polyposis; Small deletions CD065761; Colorectal cancer; Small deletions CD085021; Colorectal cancer, non-polyposis; Small deletions CD064578; Colorectal cancer, non-polyposis; Small deletions CD994169; Colorectal cancer, non-polyposis; Small deletions CD033205; Colorectal cancer, non-polyposis; Small deletions CD962070; Colorectal cancer, non-polyposis; Small deletions CD982791; Colorectal cancer, non-polyposis; Small deletions CD032123; Colorectal cancer, non-polyposis; Small deletions CD962077; Colorectal cancer, non-polyposis; Small deletions CD962630; Colorectal cancer, non-polyposis; Small deletions CD941725; Colorectal cancer, non-polyposis; Small deletions CD092212; Lynch syndrome; Small deletions CD054966; Colorectal cancer, non-polyposis; Small deletions CD010632; Colorectal cancer, non-polyposis; Small deletions CD056821; Colorectal cancer, non-polyposis; Small deletions CD032124; Colorectal cancer, non-polyposis; Small deletions CD064579; Colorectal cancer, non-polyposis; Small deletions CD014271; Colorectal cancer, non-polyposis; Small deletions CD962078; Colorectal cancer, non-polyposis; Small deletions CD010633; Colorectal cancer, non-polyposis; Small deletions CD994010; Colorectal cancer, non-polyposis; Small deletions CD011631; Colorectal cancer, non-polyposis; Small deletions CD056175; Colorectal cancer, non-polyposis; Small deletions CD011634; Colorectal cancer, non-polyposis; Small deletions CD962629; Colorectal cancer, non-polyposis; Small deletions CD034343; Colorectal cancer; Small deletions CD064580; Colorectal cancer, non-polyposis; Small deletions CD085162; Colorectal cancer, non-polyposis; Small deletions CD001901; Colorectal cancer, non-polyposis; Small deletions HD971451; Colorectal cancer, non-polyposis; Small deletions CD013856; Colorectal cancer, non-polyposis; Small deletions CD065762; Colorectal cancer; Small deletions CD092215; Lynch syndrome; Small deletions CD051759; Colorectal cancer, non-polyposis; Small deletions CD056176; Colorectal cancer, non-polyposis; Small deletions CD056177; Colorectal cancer, non-polyposis; Small deletions CD044147; Colorectal cancer, non-polyposis; Small deletions CD085020; Colorectal cancer, non-polyposis; Small deletions CD054967; Colorectal cancer, non-polyposis; Small deletions CD057967; Colorectal cancer, non-polyposis; Small deletions CD972321; Colorectal cancer, non-polyposis; Small deletions CD064581; Colorectal cancer, non-polyposis; Small deletions CD994516; Colorectal cancer, non-polyposis; Small deletions CD010631; Colorectal cancer, non-polyposis; Small deletions CD972325; Colorectal cancer, non-polyposis; Small deletions CD056178; Colorectal cancer, non-polyposis; Small deletions CD040907; Colorectal cancer, non-polyposis; Small deletions CD056179; Colorectal cancer, non-polyposis; Small deletions CD951778; Colorectal cancer, non-polyposis; Small deletions CD075469; Colorectal cancer, non-polyposis; Small deletions CD040595; Colorectal cancer, non-polyposis; Small deletions CD075470; Colorectal cancer, non-polyposis; Small deletions CD962076; Colorectal cancer, non-polyposis; Small deletions HD060522; Colorectal cancer, non-polyposis; Small deletions CD972323; Colorectal cancer, non-polyposis; Small deletions CD012006; Colorectal cancer, non-polyposis; Small deletions CD056180; Colorectal cancer, non-polyposis; Small deletions CD972324; Colorectal cancer, non-polyposis; Small deletions CD041922; Colorectal cancer, non-polyposis; Small deletions CD993408; Colorectal cancer, non-polyposis; Small deletions CD065763; Breast and colorectal cancer; Small deletions CD040908; Colorectal cancer, non-polyposis; Small deletions CD962071; Colorectal cancer, non-polyposis; Small deletions CD057524; Colorectal cancer, non-polyposis; Small deletions CD077777; Colorectal cancer, young-onset; Small deletions CD991797; Colorectal cancer, non-polyposis; Small deletions CD962072; Colorectal cancer, non-polyposis; Small deletions CD056181; Colorectal cancer, non-polyposis; Small deletions CD066375; Colorectal cancer; Small deletions CD076830; Colorectal cancer, non-polyposis; Small deletions CD054968; Colorectal cancer, non-polyposis ?; Small deletions CD972322; Colorectal cancer, non-polyposis; Small deletions CD042218; Colorectal cancer, non-polyposis; Small deletions CD044979; Colorectal cancer, non-polyposis; Small deletions CD972326; Colorectal cancer, non-polyposis; Small deletions CD023524; Colorectal cancer ?; Small deletions CD054969; Colorectal cancer, non-polyposis; Small deletions CD055712; Colorectal cancer, non-polyposis; Small deletions CD994095; Colorectal cancer, non-polyposis; Small deletions CD051760; Colorectal cancer, non-polyposis; Small deletions CD056182; Colorectal cancer, non-polyposis; Small deletions CD962073; Colorectal cancer, non-polyposis; Small deletions CD010634; Colorectal cancer, non-polyposis; Small deletions CD972320; Colorectal cancer, non-polyposis; Small deletions HD040032; Colorectal cancer, non-polyposis; Small deletions CD015055; Colorectal cancer, non-polyposis; Small deletions CD983903; Colorectal cancer, non-polyposis; Small deletions CD982793; Colorectal cancer, non-polyposis; Small deletions CD092213; Lynch syndrome; Small deletions CD011629; Colorectal cancer, non-polyposis; Small deletions CG054587; Colorectal cancer, non-polyposis; Gross deletions CG024956; Colorectal cancer, non-polyposis; Gross deletions CG054585; Colorectal cancer, non-polyposis; Gross deletions CG015600; Colorectal cancer, non-polyposis; Gross deletions CG071485; Colorectal cancer, non-polyposis; Gross deletions CG055062; Colorectal cancer, non-polyposis; Gross deletions CG061593; Colorectal cancer, non-polyposis; Gross deletions CG035248; Colorectal / endometrial cancer; Gross deletions CG035247; Colorectal cancer, non-polyposis; Gross deletions CG064796; Colorectal cancer ?; Gross deletions CG061594; Colorectal cancer, non-polyposis; Gross deletions CG952335; Colorectal cancer, non-polyposis; Gross deletions CG086005; Colorectal cancer, non-polyposis; Gross deletions CG054583; Colorectal cancer, non-polyposis; Gross deletions CG024957; Colorectal cancer, non-polyposis; Gross deletions CG024958; Colorectal cancer, non-polyposis; Gross deletions CG962910; Colorectal cancer, non-polyposis; Gross deletions CG015601; Colorectal cancer, non-polyposis; Gross deletions CG066485; Colorectal cancer; Gross deletions CG054586; Colorectal cancer, non-polyposis; Gross deletions CG952336; Colorectal cancer, non-polyposis; Gross deletions CG952337; Colorectal cancer, non-polyposis; Gross deletions CG035249; Colorectal cancer, non-polyposis; Gross deletions CG061595; Colorectal cancer, non-polyposis; Gross deletions CG962911; Muir-Torre syndrome; Gross deletions CG942222; Colorectal cancer, non-polyposis; Gross deletions CG054581; Colorectal cancer, non-polyposis; Gross deletions CG091617; Colorectal cancer, non-polyposis; Gross deletions CG035250; Colorectal cancer, non-polyposis; Gross deletions CG054588; Colorectal cancer, non-polyposis; Gross deletions CG035251; Colorectal cancer, non-polyposis; Gross deletions CG054584; Colorectal cancer, non-polyposis; Gross deletions CG054582; Colorectal cancer, non-polyposis; Gross deletions CG092028; Colorectal cancer, non-polyposis; Gross deletions CG061596; Colorectal cancer, non-polyposis; Gross deletions CG962912; Colorectal cancer, non-polyposis; Gross deletions CG077084; Colorectal cancer, non-polyposis; Gross deletions CG035253; Colorectal cancer, non-polyposis; Gross deletions CG054590; Colorectal cancer, non-polyposis; Gross deletions CG054589; Colorectal cancer, non-polyposis; Gross deletions CG942223; Colorectal cancer, non-polyposis; Gross deletions CG035254; Colorectal cancer, non-polyposis; Gross deletions CG054591; Colorectal cancer, non-polyposis; Gross deletions CG064797; Colorectal cancer, non-polyposis; Gross deletions CG024959; Colorectal cancer, non-polyposis; Gross deletions CG064798; Colorectal cancer, non-polyposis; Gross deletions CG053051; Colorectal cancer, non-polyposis; Gross deletions CG065913; Colorectal cancer; Gross deletions CG024960; Colorectal cancer, non-polyposis; Gross deletions CG057287; Colorectal cancer, non-polyposis; Gross deletions CG044386; Colorectal cancer, non-polyposis; Gross deletions CG044387; Colorectal cancer, non-polyposis; Gross deletions CG044388; Colorectal cancer, non-polyposis; Gross deletions CG082376; Colorectal cancer, non-polyposis; Gross deletions CG057288; Colorectal cancer, non-polyposis; Gross deletions CG064799; Colorectal cancer, non-polyposis; Gross deletions CG044383; Colorectal cancer, non-polyposis; Gross deletions CG082377; Colorectal cancer, non-polyposis; Gross deletions CG057289; Colorectal cancer, non-polyposis; Gross deletions CG053042; Colorectal cancer, non-polyposis; Gross deletions CG057290; Colorectal cancer, non-polyposis; Gross deletions CG044384; Colorectal cancer, non-polyposis; Gross deletions CG056267; Colorectal cancer, non-polyposis; Gross deletions CG044385; Colorectal cancer, non-polyposis; Gross deletions CG994954; Colorectal cancer, non-polyposis; Gross deletions CG035252; Colorectal cancer, non-polyposis; Gross deletions CG068167; Colorectal cancer, non-polyposis; Gross deletions CG984397; Colorectal cancer, non-polyposis; Gross deletions CG015838; Colorectal cancer, non-polyposis; Gross deletions CG055866; Colorectal cancer; Gross deletions CG057291; Colorectal cancer, non-polyposis; Gross deletions CG005092; Colorectal cancer, non-polyposis; Gross deletions CG092220; Lynch syndrome; Gross deletions CG064800; Colorectal cancer, non-polyposis; Gross deletions CG045124; Colorectal cancer; Gross deletions CG055867; Colorectal cancer, non-polyposis; Gross deletions CG973492; Colorectal cancer, non-polyposis; Gross deletions CG024961; Colorectal cancer, non-polyposis; Gross deletions CG057292; Colorectal cancer, non-polyposis; Gross deletions CG024962; Colorectal cancer, non-polyposis; Gross deletions CG994955; Colorectal cancer, non-polyposis; Gross deletions CG066486; Colorectal cancer; Gross deletions CG044389; Colorectal cancer, non-polyposis; Gross deletions CG082378; Colorectal cancer, non-polyposis; Gross deletions CG092218; Lynch syndrome; Gross deletions CG044390; Colorectal cancer, non-polyposis; Gross deletions CG082379; Colorectal cancer, non-polyposis; Gross deletions CG015602; Colorectal cancer, non-polyposis; Gross deletions CG071486; Colorectal cancer, non-polyposis; Gross deletions CG044391; Colorectal cancer, non-polyposis; Gross deletions CG044392; Colorectal cancer, non-polyposis; Gross deletions CG092219; Lynch syndrome; Gross deletions CG973493; Colorectal cancer, non-polyposis; Gross deletions CG973494; Colorectal cancer, non-polyposis; Gross deletions CG035255; Colorectal cancer, non-polyposis; Gross deletions CG984398; Colorectal cancer, non-polyposis; Gross deletions CG015603; Colorectal cancer, non-polyposis; Gross deletions CN025941; Colorectal cancer, non-polyposis; Gross insertions CN035386; Colorectal cancer, non-polyposis; Gross insertions CN045363; Colorectal cancer, non-polyposis; Gross insertions CN053061; Colorectal cancer; Gross insertions CN053063; Colorectal cancer, non-polyposis; Gross insertions CN053062; Colorectal cancer; Gross insertions CN057306; Colorectal cancer, non-polyposis; Gross insertions CN071510; Colorectal cancer, non-polyposis; Gross insertions CN071511; Colorectal cancer, non-polyposis; Gross insertions CN071513; Colorectal cancer, non-polyposis; Gross insertions CX075738; Glioblastoma; Small indels CX973105; Colorectal cancer, non-polyposis; Small indels CX056899; Colorectal cancer, non-polyposis; Small indels CX057532; Colorectal cancer, non-polyposis; Small indels CX061564; Colorectal cancer, non-polyposis; Small indels CP973602; Colorectal cancer, non-polyposis; Small indels CX068359; Colorectal cancer, non-polyposis ?; Small indels CX092209; Lynch syndrome; Small indels CP995100; Colorectal cancer, non-polyposis; Small indels CX057533; Colorectal cancer, non-polyposis; Small indels CP015800; Colorectal cancer, non-polyposis; Small indels CP035449; Colorectal cancer; Small indels CX973308; Colorectal cancer, non-polyposis; Small indels CI004230; Colorectal cancer, non-polyposis; Small insertions CI065838; Colorectal cancer; Small insertions CI011692; Colorectal cancer, non-polyposis; Small insertions CI983154; Colorectal cancer, non-polyposis; Small insertions CI011688; Colorectal cancer, non-polyposis; Small insertions CI042899; Colorectal cancer, non-polyposis; Small insertions CI033576; Colorectal cancer, non-polyposis; Small insertions CI085023; Colorectal cancer, non-polyposis; Small insertions CI056229; Colorectal cancer, non-polyposis; Small insertions CI087368; Colorectal cancer with Lynch syndrome; Small insertions CI076968; Colorectal cancer, non-polyposis; Small insertions CI045844; Colorectal cancer, non-polyposis ?; Small insertions CI087316; Colorectal cancer, non-polyposis; Small insertions CI087392; Colon cancer ; Small insertions CI033960; Colorectal cancer, non-polyposis; Small insertions CI044281; Colorectal cancer, non-polyposis; Small insertions CI032154; Colorectal cancer, non-polyposis; Small insertions CI085163; Colorectal cancer, non-polyposis; Small insertions CI066430; Colorectal cancer, non-polyposis; Small insertions CI056230; Colorectal cancer, non-polyposis; Small insertions CI022930; Colorectal cancer, non-polyposis; Small insertions CI044279; Colorectal cancer, non-polyposis; Small insertions CI012028; Colorectal cancer, non-polyposis; Small insertions CI042652; Colorectal cancer, non-polyposis; Small insertions CI015057; Colorectal cancer, non-polyposis; Small insertions CI962308; Colorectal cancer, non-polyposis; Small insertions CI992052; Colorectal cancer, non-polyposis; Small insertions CI056231; Colorectal cancer, non-polyposis; Small insertions CI011691; Colorectal cancer, non-polyposis; Small insertions CI042898; Colorectal cancer, non-polyposis; Small insertions CI023723; Colorectal cancer; Small insertions CI992051; Colorectal cancer, non-polyposis; Small insertions CI044278; Colorectal cancer, non-polyposis; Small insertions CI962653; Colorectal cancer, non-polyposis; Small insertions CI994564; Colorectal cancer, non-polyposis; Small insertions CI092214; Lynch syndrome; Small insertions CI055762; Colorectal cancer, non-polyposis; Small insertions CI011690; Colorectal cancer, non-polyposis; Small insertions HI030007; Colorectal cancer, non-polyposis; Small insertions CI033292; Colorectal cancer, non-polyposis; Small insertions CI044280; Colorectal cancer, non-polyposis; Small insertions CI994674; Colorectal cancer, non-polyposis; Small insertions CI941890; Colorectal cancer, non-polyposis; Small insertions CI061537; Colorectal cancer, non-polyposis; Small insertions CI951952; Colorectal cancer, non-polyposis; Small insertions CI962310; Colorectal cancer, non-polyposis; Small insertions CI043960; Colorectal cancer, non-polyposis; Small insertions CI042900; Colorectal cancer, non-polyposis; Small insertions CI962309; Colorectal cancer, non-polyposis; Small insertions CI092657; Colorectal cancer, non-polyposis; Small insertions CI092216; Lynch syndrome; Small insertions CI010717; Colorectal cancer, non-polyposis; Small insertions CI015058; Colorectal cancer, non-polyposis; Small insertions CI011687; Lynch syndrome; Small insertions CI983155; Colorectal cancer, non-polyposis; Small insertions CI024072; Colorectal cancer, non-polyposis; Small insertions CI031100; Colorectal cancer, non-polyposis; Small insertions CI032153; Colorectal cancer, non-polyposis; Small insertions CI013883; Colorectal cancer, non-polyposis; Small insertions HI971337; Colorectal cancer, non-polyposis; Small insertions CI992049; Cystic sebaceous tumour; Small insertions CI951953; Colorectal cancer, non-polyposis; Small insertions CI057530; Colorectal cancer, non-polyposis; Small insertions CI042651; Colorectal cancer, non-polyposis; Small insertions CI972643; Colorectal cancer, non-polyposis; Small insertions CI015060; Colorectal cancer; Small insertions CM970949; Colorectal cancer, non-polyposis; Missense/nonsense CM970950; Colorectal cancer, non-polyposis; Missense/nonsense CM065312; Colorectal cancer; Missense/nonsense CM011407; Colorectal cancer, non-polyposis; Missense/nonsense CM033399; Colorectal cancer, non-polyposis ?; Missense/nonsense CM023425; Colorectal cancer, non-polyposis ?; Missense/nonsense CM044666; Colorectal cancer, non-polyposis; Missense/nonsense CM044667; Colorectal cancer ?; Missense/nonsense CM076304; Colorectal cancer; Missense/nonsense CM057966; Colorectal cancer, non-polyposis ?; Missense/nonsense CM013767; Colorectal cancer, non-polyposis; Missense/nonsense CM076294; Colorectal cancer; Missense/nonsense CM011408; Colorectal cancer, non-polyposis; Missense/nonsense CM993950; Colorectal cancer, non-polyposis; Missense/nonsense CM972992; Colorectal cancer, non-polyposis; Missense/nonsense CM031242; Colorectal cancer, non-polyposis; Missense/nonsense CM023952; Colorectal cancer, non-polyposis; Missense/nonsense CM950798; Colorectal cancer, non-polyposis; Missense/nonsense CM085543; Colorectal cancer, non-polyposis ?; Missense/nonsense CM055990; Colorectal cancer, non-polyposis; Missense/nonsense CM010343; Colorectal cancer, non-polyposis; Missense/nonsense CM023953; Colorectal cancer, non-polyposis; Missense/nonsense CM042739; Colorectal cancer, non-polyposis; Missense/nonsense CM941059; Colorectal cancer, non-polyposis; Missense/nonsense HM030036; Colorectal cancer, non-polyposis; Missense/nonsense CM068360; Colorectal cancer, non-polyposis ?; Missense/nonsense CM970951; Colorectal cancer, non-polyposis; Missense/nonsense CM950799; Colorectal cancer, non-polyposis; Missense/nonsense CM076293; Colorectal cancer, non-polyposis; Missense/nonsense CM057502; Colorectal cancer, non-polyposis; Missense/nonsense CM970952; Colorectal cancer, non-polyposis; Missense/nonsense HM030035; Colorectal cancer, non-polyposis; Missense/nonsense CM970953; Colorectal cancer, non-polyposis; Missense/nonsense CM990854; Colorectal cancer, non-polyposis; Missense/nonsense CM065314; Colorectal cancer; Missense/nonsense CM950801; Colorectal cancer, non-polyposis; Missense/nonsense CM055986; Colorectal cancer, non-polyposis; Missense/nonsense CM981288; Colorectal cancer, non-polyposis; Missense/nonsense CM970954; Colorectal cancer, non-polyposis; Missense/nonsense CM015002; Colorectal cancer, non-polyposis; Missense/nonsense CM995218; Colorectal cancer, non-polyposis; Missense/nonsense CM994124; Colorectal cancer, non-polyposis; Missense/nonsense CM054777; Colorectal cancer, non-polyposis; Missense/nonsense CM024457; Colorectal cancer, non-polyposis; Missense/nonsense CM981289; Colorectal cancer, non-polyposis ?; Missense/nonsense CM077605; Colorectal cancer, young-onset; Missense/nonsense CM076298; Colorectal cancer; Missense/nonsense CM990855; Colorectal cancer, non-polyposis; Missense/nonsense CM033398; Colorectal cancer, non-polyposis ?; Missense/nonsense CM076305; Colorectal cancer ?; Missense/nonsense CM011409; Colorectal cancer, non-polyposis ?; Missense/nonsense CM068361; Colorectal cancer, non-polyposis ?; Missense/nonsense CM015025; Gastric cancer ?; Missense/nonsense CM960964; Colorectal cancer, non-polyposis; Missense/nonsense CM015026; Gastric cancer ?; Missense/nonsense CM001243; Colorectal cancer, non-polyposis; Missense/nonsense CM068362; Colorectal cancer, non-polyposis ?; Missense/nonsense CM950802; Colorectal cancer, non-polyposis; Missense/nonsense CM960965; Colorectal cancer, non-polyposis; Missense/nonsense CM015027; Colorectal cancer, non-polyposis; Missense/nonsense CM015028; Colorectal cancer, non-polyposis; Missense/nonsense CM004561; Colorectal cancer, non-polyposis; Missense/nonsense CM970955; Colorectal cancer, non-polyposis; Missense/nonsense CM054778; Colorectal cancer, non-polyposis; Missense/nonsense CM041802; Colorectal cancer, non-polyposis ?; Missense/nonsense CM970956; Colorectal cancer, non-polyposis; Missense/nonsense CM061115; Colorectal cancer, non-polyposis ?; Missense/nonsense CM056647; Colorectal cancer, non-polyposis; Missense/nonsense CM013768; Colorectal cancer, non-polyposis; Missense/nonsense CM053325; Colorectal cancer, non-polyposis; Missense/nonsense CM076307; Colorectal cancer; Missense/nonsense CM085551; Colorectal cancer, non-polyposis; Missense/nonsense CM085552; Colorectal cancer, non-polyposis ?; Missense/nonsense CM033400; Colorectal cancer, non-polyposis ?; Missense/nonsense CM970957; Colorectal cancer, non-polyposis; Missense/nonsense CM960966; Colorectal cancer, non-polyposis; Missense/nonsense CM085541; Colorectal cancer, non-polyposis ?; Missense/nonsense CM981290; Colorectal cancer, non-polyposis; Missense/nonsense CM055989; Colorectal cancer, non-polyposis; Missense/nonsense CM990856; Colorectal cancer, non-polyposis; Missense/nonsense CM011410; Colorectal cancer, non-polyposis; Missense/nonsense CM000176; Colorectal cancer, non-polyposis ?; Missense/nonsense CM950803; Colorectal cancer, non-polyposis ?; Missense/nonsense CM970958; Colorectal cancer, non-polyposis ?; Missense/nonsense CM045463; Colorectal cancer, non-polyposis; Missense/nonsense CM082944; Colorectal cancer, non-polyposis; Missense/nonsense CM960967; Colorectal cancer, non-polyposis; Missense/nonsense CM015029; Colorectal cancer, non-polyposis ?; Missense/nonsense CM970959; Colorectal cancer, non-polyposis; Missense/nonsense CM023954; Colorectal cancer, non-polyposis; Missense/nonsense CM941060; Colorectal cancer, non-polyposis; Missense/nonsense CM004724; Colorectal cancer; Missense/nonsense CM076296; Colorectal cancer; Missense/nonsense CM022223; Colorectal cancer, non-polyposis; Missense/nonsense CM973081; Colorectal cancer, non-polyposis ?; Missense/nonsense CM064120; Colorectal cancer, non-polyposis; Missense/nonsense CM011411; Colorectal cancer, non-polyposis; Missense/nonsense CM981291; Colorectal cancer, non-polyposis; Missense/nonsense CM970960; Colorectal cancer, non-polyposis; Missense/nonsense CM076303; Colorectal cancer ?; Missense/nonsense CM082947; Colorectal cancer, non-polyposis; Missense/nonsense CM055988; Colorectal cancer, non-polyposis; Missense/nonsense CM076306; Colorectal cancer ?; Missense/nonsense CM042740; Colorectal cancer, non-polyposis; Missense/nonsense CM057504; Colorectal cancer, non-polyposis; Missense/nonsense CM973728; Colorectal cancer, non-polyposis; Missense/nonsense CM023426; Colorectal cancer, non-polyposis ?; Missense/nonsense CM082946; Colorectal cancer, non-polyposis; Missense/nonsense CM970961; Colorectal cancer, non-polyposis; Missense/nonsense CM052253; Colorectal cancer, non-polyposis; Missense/nonsense CM970962; Colorectal cancer, non-polyposis; Missense/nonsense CM970963; Colorectal cancer, non-polyposis; Missense/nonsense CM085549; Colorectal cancer, non-polyposis ?; Missense/nonsense CM004725; Colorectal cancer, non-polyposis; Missense/nonsense CM085544; Colorectal cancer, non-polyposis ?; Missense/nonsense CM013001; Colorectal cancer, non-polyposis; Missense/nonsense CM015030; Colorectal cancer, non-polyposis ?; Missense/nonsense CM960968; Colorectal cancer, non-polyposis; Missense/nonsense CM970964; Colorectal cancer, non-polyposis; Missense/nonsense CM085547; Colorectal cancer, non-polyposis; Missense/nonsense CM023644; Colorectal cancer, non-polyposis; Missense/nonsense CM092210; Lynch syndrome; Missense/nonsense CM061116; Colorectal cancer, non-polyposis; Missense/nonsense CM995222; Colorectal cancer, non-polyposis ?; Missense/nonsense CM033401; Colorectal cancer, non-polyposis ?; Missense/nonsense CM981292; Colorectal cancer, non-polyposis ?; Missense/nonsense CM994601; Colorectal cancer, non-polyposis; Missense/nonsense CM022425; Colorectal cancer, non-polyposis; Missense/nonsense CM076299; Colorectal cancer ?; Missense/nonsense CM092211; Lynch syndrome; Missense/nonsense CM051559; Colorectal cancer, non-polyposis; Missense/nonsense CM044233; Colorectal cancer, non-polyposis; Missense/nonsense CM014585; Colorectal cancer, non-polyposis ?; Missense/nonsense CM074936; Colorectal cancer, non-polyposis; Missense/nonsense CM076291; Colorectal cancer ?; Missense/nonsense CM085550; Colorectal cancer, non-polyposis ?; Missense/nonsense CM076309; Colorectal cancer ?; Missense/nonsense CM021301; Colorectal cancer, non-polyposis; Missense/nonsense CM970965; Colorectal cancer, non-polyposis; Missense/nonsense CM053322; Colorectal cancer, non-polyposis; Missense/nonsense CM068363; Colorectal cancer, non-polyposis ?; Missense/nonsense CM076295; Colorectal cancer, non-polyposis; Missense/nonsense CM972921; Colorectal cancer, non-polyposis; Missense/nonsense CM015059; Colorectal cancer; Missense/nonsense CM011412; Colorectal cancer, non-polyposis ?; Missense/nonsense CM994125; Colorectal cancer, non-polyposis; Missense/nonsense CM015031; Colorectal cancer, non-polyposis ?; Missense/nonsense CM000177; Colorectal cancer, non-polyposis; Missense/nonsense CM960969; Colorectal cancer, non-polyposis; Missense/nonsense CM076297; Colorectal cancer ?; Missense/nonsense CM960970; Colorectal cancer, non-polyposis; Missense/nonsense CM087245; Colorectal cancer, non-polyposis; Missense/nonsense CM010344; Colorectal cancer, non-polyposis; Missense/nonsense CM074937; Colorectal cancer, non-polyposis; Missense/nonsense CM057503; Colorectal cancer, non-polyposis; Missense/nonsense CM994509; Colorectal cancer, non-polyposis; Missense/nonsense CM040767; Colorectal cancer, non-polyposis; Missense/nonsense CM042741; Colorectal cancer, non-polyposis; Missense/nonsense CM950804; Colorectal cancer, non-polyposis; Missense/nonsense CM055992; Colorectal cancer, non-polyposis; Missense/nonsense CM972922; Colorectal cancer, non-polyposis; Missense/nonsense CM960971; Colorectal cancer, non-polyposis; Missense/nonsense CM053324; Colorectal cancer, non-polyposis; Missense/nonsense CM970966; Colorectal cancer, non-polyposis; Missense/nonsense CM052901; Colorectal cancer, non-polyposis; Missense/nonsense CM990857; Colorectal cancer, non-polyposis; Missense/nonsense CM033402; Colorectal cancer, non-polyposis ?; Missense/nonsense CM085545; Colorectal cancer, non-polyposis; Missense/nonsense CM055987; Colorectal cancer, non-polyposis; Missense/nonsense CM000001; Colorectal cancer, non-polyposis; Missense/nonsense CM981293; Colorectal cancer, non-polyposis; Missense/nonsense CM950805; Colorectal cancer, non-polyposis; Missense/nonsense CM950806; Colorectal cancer, non-polyposis; Missense/nonsense CM066133; Colorectal cancer, non-polyposis; Missense/nonsense CM076300; Colorectal cancer, non-polyposis ?; Missense/nonsense CM950807; Colorectal cancer, non-polyposis; Missense/nonsense CM068364; Colorectal cancer, non-polyposis ?; Missense/nonsense CM030902; Colorectal cancer, non-polyposis; Missense/nonsense CM001244; Colorectal cancer, non-polyposis; Missense/nonsense CM053326; Colorectal cancer, non-polyposis; Missense/nonsense CM030903; Colorectal cancer ?; Missense/nonsense CM015003; Colorectal cancer, non-polyposis ?; Missense/nonsense CM994061; Colorectal cancer, non-polyposis; Missense/nonsense CM000178; Colorectal cancer, non-polyposis ?; Missense/nonsense CM085548; Colorectal cancer, non-polyposis ?; Missense/nonsense CM950808; Colorectal cancer, non-polyposis; Missense/nonsense CM973729; Colorectal cancer, non-polyposis ?; Missense/nonsense CM981294; Colorectal cancer, non-polyposis; Missense/nonsense CM013002; Colorectal cancer, non-polyposis; Missense/nonsense CM060050; Colorectal cancer, non-polyposis ?; Missense/nonsense CM076308; Colorectal cancer, non-polyposis; Missense/nonsense CM015032; Colorectal cancer, non-polyposis ?; Missense/nonsense CM015033; Gastric cancer ?; Missense/nonsense CM042742; Colorectal cancer, non-polyposis; Missense/nonsense CM076292; Colorectal cancer; Missense/nonsense CM042743; Colorectal cancer, non-polyposis; Missense/nonsense CM022426; Colorectal cancer, non-polyposis; Missense/nonsense CM015004; Colorectal cancer, non-polyposis; Missense/nonsense CM022817; Colorectal cancer, non-polyposis; Missense/nonsense CM076302; Colorectal cancer; Missense/nonsense CM053323; Colorectal cancer, non-polyposis; Missense/nonsense CM963038; Colorectal cancer, non-polyposis; Missense/nonsense CM023747; Endometrial cancer; Missense/nonsense CM011413; Colorectal cancer, non-polyposis ?; Missense/nonsense CM960972; Colorectal cancer, non-polyposis; Missense/nonsense CM000179; Colorectal cancer, non-polyposis; Missense/nonsense CM960973; Colorectal cancer, non-polyposis; Missense/nonsense CM013769; Colorectal cancer, non-polyposis; Missense/nonsense CM085546; Colorectal cancer, non-polyposis ?; Missense/nonsense CM023645; Colorectal cancer, non-polyposis; Missense/nonsense CM076301; Colorectal cancer; Missense/nonsense CM085542; Colorectal cancer, non-polyposis ?; Missense/nonsense CM054779; Colorectal cancer, non-polyposis; Missense/nonsense CM960974; Colorectal cancer, non-polyposis; Missense/nonsense CM010124; Colorectal cancer, non-polyposis; Missense/nonsense CM015005; Colorectal cancer, non-polyposis; Missense/nonsense CM057192; Colorectal cancer, non-polyposis; Missense/nonsense CM942064; Colorectal cancer, non-polyposis; Missense/nonsense CM066579; Gastric cancer ?; Missense/nonsense CM065313; Colorectal cancer, non-polyposis; Missense/nonsense CM960975; Colorectal cancer, non-polyposis; Missense/nonsense CM055991; Colorectal cancer, non-polyposis; Missense/nonsense CM960976; Colorectal cancer, non-polyposis; Missense/nonsense CM960977; Colorectal cancer, non-polyposis; Missense/nonsense CM981295; Colorectal cancer, non-polyposis ?; Missense/nonsense CM014821; Colorectal cancer, non-polyposis ?; Missense/nonsense CM000180; Colorectal cancer, non-polyposis; Missense/nonsense CM042744; Colorectal cancer, non-polyposis; Missense/nonsense CM082945; Colorectal cancer, non-polyposis; Missense/nonsense CM076310; Colorectal cancer ?; Missense/nonsense CM003944; Colorectal cancer, non-polyposis; Missense/nonsense CM068375; Colorectal cancer, non-polyposis ?; Missense/nonsense CM034246; Colorectal cancer; Missense/nonsense CM994062; Colorectal cancer, non-polyposis; Missense/nonsense HM971468; Colorectal cancer, non-polyposis; Missense/nonsense CM995219; Colorectal cancer, non-polyposis; Missense/nonsense CM092217; Lynch syndrome; Missense/nonsense CM990858; Colorectal cancer, non-polyposis; Missense/nonsense CR064470; Colorectal cancer, non-polyposis ?; Regulatory CR015014; Colorectal cancer, non-polyposis ?; Regulatory CR045225; Lung cancer, risk, assoc. with; Regulatory CR015013; Colorectal cancer, non-polyposis ?; Regulatory CR033148; Colorectal cancer, non-polyposis ?; Regulatory CS994149; Colorectal cancer, non-polyposis; Splicing CS042552; Colorectal cancer, non-polyposis; Splicing CS004501; Colorectal cancer, non-polyposis; Splicing CS001439; Turcot syndrome; Splicing CS024017; Colorectal cancer, non-polyposis; Splicing CS983701; Colorectal cancer, non-polyposis; Splicing CS055602; Colorectal cancer, non-polyposis; Splicing CS066640; Colorectal cancer, non-polyposis; Splicing CS065592; Colorectal cancer; Splicing CS064424; Colorectal cancer, non-polyposis; Splicing CS971799; Colorectal cancer, non-polyposis; Splicing CS016087; Colorectal cancer, non-polyposis ?; Splicing CS076627; Colorectal cancer, non-polyposis; Splicing CS086119; Colorectal cancer, non-polyposis; Splicing CS024018; Colorectal cancer, non-polyposis; Splicing CS056102; Colorectal cancer, non-polyposis; Splicing CS056103; Colorectal cancer, non-polyposis; Splicing CS056104; Colorectal cancer, non-polyposis; Splicing CS084767; Colorectal cancer, non-polyposis; Splicing CS971800; Colorectal cancer, non-polyposis; Splicing CS086120; Colorectal cancer, non-polyposis; Splicing CS015011; Colorectal cancer, non-polyposis ?; Splicing CS045711; Colorectal cancer, non-polyposis; Splicing CS061300; Colorectal cancer, non-polyposis; Splicing CS086121; Colorectal cancer, non-polyposis; Splicing CS011553; Colorectal cancer, non-polyposis; Splicing CS015048; Colorectal cancer, non-polyposis ?; Splicing CS015047; Colorectal cancer, non-polyposis ?; Splicing CS076628; Colorectal cancer, non-polyposis ?; Splicing CS971801; Colorectal cancer, non-polyposis; Splicing CS971802; Colorectal cancer, non-polyposis; Splicing CS024019; Colorectal cancer, non-polyposis; Splicing CS066294; Colorectal cancer; Splicing CS092658; Colorectal cancer, non-polyposis; Splicing CS056105; Colorectal cancer, non-polyposis; Splicing CS057515; Colorectal cancer, non-polyposis; Splicing CS961619; Colorectal cancer, non-polyposis; Splicing CS052411; Colorectal cancer, non-polyposis ?; Splicing CS011554; Colorectal cancer, non-polyposis; Splicing CS010558; Colorectal cancer, non-polyposis; Splicing CS011555; Colorectal cancer, non-polyposis; Splicing CS033502; Colorectal cancer, non-polyposis; Splicing CS042555; Colorectal cancer, non-polyposis; Splicing CS042556; Colorectal cancer, non-polyposis; Splicing CS961620; Colorectal cancer, non-polyposis; Splicing CS056106; Colorectal cancer, non-polyposis; Splicing CS087457; Colorectal cancer, non-polyposis; Splicing CS961622; Colorectal cancer, non-polyposis; Splicing CS961621; Colorectal cancer, non-polyposis; Splicing CS086118; Colorectal cancer, non-polyposis; Splicing CS085160; Colorectal cancer, non-polyposis; Splicing CS056762; Colorectal cancer, non-polyposis; Splicing CS056107; Colorectal cancer, non-polyposis; Splicing CS961623; Colorectal cancer, non-polyposis; Splicing CS994082; Colorectal cancer, non-polyposis; Splicing CS077657; Colorectal cancer, non-polyposis; Splicing CS040846; Colorectal cancer, non-polyposis; Splicing CS994300; Colorectal cancer, non-polyposis; Splicing CS973362; Colorectal cancer, non-polyposis; Splicing CS042818; Colorectal cancer, non-polyposis; Splicing CS011557; Colorectal cancer, non-polyposis; Splicing CS013100; Colorectal cancer, non-polyposis; Splicing CS056108; Colorectal cancer, non-polyposis; Splicing CS011558; Colorectal cancer, non-polyposis; Splicing CS016088; Colorectal cancer, non-polyposis; Splicing CS033503; Colorectal cancer, non-polyposis; Splicing CS971803; Colorectal cancer, non-polyposis; Splicing CS011052; Colorectal cancer, non-polyposis ?; Splicing CS991451; Colorectal cancer, non-polyposis; Splicing CS994150; Colorectal cancer, non-polyposis; Splicing CS042819; Colorectal cancer, non-polyposis; Splicing CS951473; Colorectal cancer, non-polyposis; Splicing CS033504; Colorectal cancer, non-polyposis; Splicing CS015012; Colorectal cancer, non-polyposis ?; Splicing CS011559; Colorectal cancer, non-polyposis; Splicing CS961624; Colorectal cancer, non-polyposis; Splicing CS056109; Colorectal cancer, non-polyposis; Splicing CS042557; Colorectal cancer, non-polyposis; Splicing CS951468; Colorectal cancer, non-polyposis; Splicing HS040023; Colorectal cancer, non-polyposis; Splicing CS085161; Colorectal cancer, non-polyposis; Splicing CS056110; Colorectal cancer, non-polyposis; Splicing CS031451; Colorectal cancer, non-polyposis; Splicing CS076629; Colorectal cancer, non-polyposis; Splicing CS086114; Colorectal cancer, non-polyposis; Splicing CS004575; Colorectal cancer, non-polyposis; Splicing CS033127; Colorectal cancer, non-polyposis; Splicing CS064425; Colorectal cancer, non-polyposis ?; Splicing CS962623; Colorectal cancer, non-polyposis; Splicing CS010557; Colorectal cancer, non-polyposis; Splicing CS066295; Colorectal cancer, non-polyposis; Splicing CS056111; Colorectal cancer, non-polyposis; Splicing CS011548; Colorectal cancer, non-polyposis; Splicing CS052410; Colorectal cancer, non-polyposis; Splicing CS076630; Colorectal cancer, non-polyposis; Splicing CS068358; Colorectal cancer, non-polyposis; Splicing CS951469; Colorectal cancer, non-polyposis; Splicing CS031452; Colorectal cancer, non-polyposis; Splicing CS984645; Colorectal cancer, non-polyposis; Splicing CS011549; Colorectal cancer, non-polyposis; Splicing CS011550; Colorectal cancer, non-polyposis; Splicing CS961615; Colorectal cancer, non-polyposis; Splicing CS042553; Colorectal cancer, non-polyposis; Splicing CS971797; Colorectal cancer, non-polyposis; Splicing CS056112; Colorectal cancer, non-polyposis; Splicing CS064426; Colorectal cancer, non-polyposis; Splicing CS951470; Colorectal cancer, non-polyposis; Splicing CS031453; Colorectal cancer, non-polyposis; Splicing CS057516; Colorectal cancer, non-polyposis; Splicing CS011551; Colorectal cancer, non-polyposis; Splicing CS086384; Colorectal cancer, non-polyposis; Splicing CS065593; Colorectal cancer; Splicing CS045328; Colorectal cancer, non-polyposis; Splicing CS056763; Colorectal cancer, non-polyposis; Splicing CS994671; Colorectal cancer, non-polyposis; Splicing CS042817; Colorectal cancer, non-polyposis; Splicing CS031454; Colorectal cancer, non-polyposis; Splicing CS961616; Colorectal cancer, non-polyposis; Splicing CS023479; Colorectal cancer, non-polyposis; Splicing CS951471; Colorectal cancer, non-polyposis; Splicing CS042554; Colorectal cancer, non-polyposis; Splicing CS961617; Colorectal cancer, non-polyposis; Splicing CS994083; Colorectal cancer, non-polyposis; Splicing CS086117; Colorectal cancer, non-polyposis; Splicing CS971798; Colorectal cancer, non-polyposis; Splicing CS086116; Colorectal cancer, non-polyposis; Splicing CS961618; Colorectal cancer, non-polyposis; Splicing CS011552; Colorectal cancer, non-polyposis; Splicing CS982272; Colorectal cancer, non-polyposis; Splicing CS086115; Colorectal cancer, non-polyposis; Splicing CS951472; Colorectal cancer, non-polyposis; Splicing CS055603; Colorectal cancer, non-polyposis; Splicing |
| GWASdb (count: 2) | rs1800734; Drug response to Dacarbazine; Null
rs1800734; Drug response to Procarbazine; Null |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 22) (view all) | 183 ILEVVGRYSVHNAGI dbPAF
184 LEVVGRYSVHNAGIS dbPAF 212 RTLPNASTVDNIRSI dbPAF 269 INHRLVESTSLRKAI dbPAF 288 AAYLPKNTHPFLYLS dbPAF 293 KNTHPFLYLSLEISP dbPAF 295 THPFLYLSLEISPQN dbPAF
370 TTSLTSSSTSGSSDK dbPAF 372 SLTSSSTSGSSDKVY dbPAF 374 TSSSTSGSSDKVYAH dbPAF 375 SSSTSGSSDKVYAHQ dbPAF 379 SGSSDKVYAHQMVRT dbPAF 386 YAHQMVRTDSREQKL dbPAF 388 HQMVRTDSREQKLDA dbPAF 406 PLSKPLSSQPQAIVT dbPAF 446 EVAAKNQSLEGDTTK dbPAF 455 EGDTTKGTSEMSEKR dbPAF 467 EKRGPTSSNPRKRHR dbPAF 477 RKRHREDSDVEMVED dbPAF 486 VEMVEDDSRKEMTAA dbPAF 495 KEMTAACTPRRRIIN dbPAF 508 INLTSVLSLQEEINE dbPAF |
| Acetylation (count: 6) | 195 AGISFSVKKQGETVA PLMD
236 IEIGCEDKTLAFKMN PLMD 377 STSGSSDKVYAHQMV PLMD 402 AFLQPLSKPLSSQPQ PLMD 443 APAEVAAKNQSLEGD PLMD 461 GTSEMSEKRGPTSSN PLMD |
| Ubiquitination (count: 17) (view all) | 136 SYSDGKLKAPPKPCA PLMD
140 GKLKAPPKPCAGNQG PLMD 164 YNIATRRKALKNPSE PLMD 167 ATRRKALKNPSEEYG PLMD 175 NPSEEYGKILEVVGR PLMD 196 GISFSVKKQGETVAD PLMD 33 QRPANAIKEMIENCL PLMD
333 VQQHIESKLLGSNSS PLMD 361 GPSGEMVKSTTSLTS PLMD 377 STSGSSDKVYAHQMV PLMD 453 SLEGDTTKGTSEMSE PLMD 488 MVEDDSRKEMTAACT PLMD 57 IVKEGGLKLIQIQDN PLMD 688 AMFYSIRKQYISEES PLMD 70 DNGTGIRKEDLDIVC PLMD 732 RSHILPPKHFTEDGN PLMD 84 CERFTTSKLQSFEDL PLMD |
| Sumoylation (count: 2) | 392 RTDSREQKLDAFLQP PLMD
416 QAIVTEDKTDISSGR PLMD |
| Glycation (count: 1) | 461 GTSEMSEKRGPTSSN PLMD |