Q6U949

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession IG2AS_HUMAN; Q6U949;
Entrez ID 51214
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Putative insulin-like growth factor 2 antisense gene protein (IGF2 antisense RNA 1) (IGF2 antisense gene protein 1) (PEG8/IGF2AS protein) (Putative insulin-like growth factor 2 antisense gene protein 1) (IGF2-AS1)
Gene Name IGF2-AS; IGF2-AS1; IGF2AS
Organism Homo sapiens
NCBI Taxa ID 9606
Sequence
(Fasta)		MSKRKWRGFR GAQQERAQPP AASPQPCPAP HAGLPGGSRR RAPAPAGQQQ MRAESRSGAQ 60
RRRGSARRGA HREAGGCVRG RTRSSGSERS NALWQAVDAA EALALSSPLR RPWDQAQHFT 120
NPAPFSKGPQ SAPPSPPAGR RRRGADLALT PLAGEGHTRW RQPGRPGK 169

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1MethylationColon cancer/carcinomaD3857949; 23962719
[Reference]: we found that the CTCF-orchestrated intrachromosomal loop between the IGF2 promoters and the imprinting control region was abrogated in cells with LOI. SUZ12, which docks the PRC2 to IGF2 promoters for H3K27 methylation, was downregulated in LOI cells. These data reveal a new epigenetic control pathway related to the loss of IGF2 imprinting in tumors.


※ PTM Sites

PTM Modification Sites