O95715

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession CXL14_HUMAN; O95715;
Entrez ID 9547
GenBank Protein ID
GenBank Nucleotide ID
Protein Name C-X-C motif chemokine 14 (Chemokine BRAK) (MIP-2G) (Small-inducible cytokine B14)
Gene Name CXCL14; MIP2G; NJAC; SCYB14; PSEC0212; UNQ240/PRO273
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionPotent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays.
Sequence
(Fasta)		MSLLPRRAPP VSMRLLAAAL LLLLLALYTA RVDGSKCKCS RKGPKIRYSD VKKLEMKPKY 60
PHCEEKMVII TTKSVSRYRG QEHCLHPKLQ STKRFIKWYN AWNEKRRVYE E 112

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1MethylationColon cancer/carcinomaP24099668
[Reference]: Partial methylation and weak expression were found in two cell lines. CXCL14 was methylated in 79.4% (85/107) of primary human colorectal cancer

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 5)		MESH:D001249 ; Asthma
MESH:D003877 ; Dermatitis, Contact
MESH:D004715 ; Endometriosis
MESH:D008175 ; Lung Neoplasms
MESH:D019966 ; Substance-Related Disorders

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 2)		 12        PRRAPPVSMRLLAAA     dbPAF
72        EKMVIITTKSVSRYR     dbPAF

※ Protein-Protein Interaction

NetworkInteraction
ABSource