Tag | Content |
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UniProt Accession | PTEN_HUMAN; P60484; |
Entrez ID | 5728 |
GenBank Protein ID | NM_000314.6; NM_001304717.2; NM_001304718.1; |
GenBank Nucleotide ID | NP_000305.3; NP_001291646.2; NP_001291647.1; |
Protein Name | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog) |
Gene Name | PTEN; MMAC1; TEP1 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4 (PubMed:26504226). The lipid phosphatase activity (view all) |
Sequence (Fasta) | MTAIIKEIVS RNKRRYQEDG FDLDLTYIYP NIIAMGFPAE RLEGVYRNNI DDVVRFLDSK 60 HKNHYKIYNL CAERHYDTAK FNCRVAQYPF EDHNPPQLEL IKPFCEDLDQ WLSEDDNHVA 120 AIHCKAGKGR TGVMICAYLL HRGKFLKAQE ALDFYGEVRT RDKKGVTIPS QRRYVYYYSY 180 LLKNHLDYRP VALLFHKMMF ETIPMFSGGT CNPQFVVCQL KVKIYSSNSG PTRREDKFMY 240 FEFPQPLPVC GDIKVEFFHK QNKMLKKDKM FHFWVNTFFI PGPEETSEKV ENGSLCDQEI 300 DSICSIERAD NDKEYLVLTL TKNDLDKANK DKANRYFSPN FKVKLYFTKT VEEPSNPEAS 360 SSTSVTPDVS DNEPDHYRYS DTTDSDPENE PFDEDQHTQI TKV 404 |
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Database | Annotation |
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Cancer Gene Census | glioma, prostate, endometrial harmartoma, glioma, prostate, endometrial Cowden syndrome, Bannayan-Riley-Ruvalcaba syndrome |
CTD (Curated) (count: 58) (view all) | MESH:D000015
; Abnormalities, Multiple MESH:D000230 ; Adenocarcinoma MESH:D018248 ; Adenoma, Liver Cell MESH:D015858 ; Anisometropia MESH:D001249 ; Asthma MESH:D001321 ; Autistic Disorder |
HGMD (count: 226) (view all) | CP995110; Bannayan-Riley-Ruvalcaba syndrome; Complex rearrangements
CD075524; Cowden disease; Small deletions CD991851; Bannayan-Riley-Ruvalcaba syndrome; Small deletions CD982915; Bannayan-Zonana syndrome; Small deletions CD075525; Cowden disease; Small deletions CD020869; Cowden disease; Small deletions |
GWASdb (count: 8) (view all) | rs1903858; Type 2 diabetes; type 2 diabetes mellitus
rs1234225; Type 2 diabetes; type 2 diabetes mellitus rs1234224; Type 2 diabetes; type 2 diabetes mellitus rs12357281; Urinary metabolites; kidney disease rs12242772; Cholesterol, total; coronary artery disease|lipid metabolism disorder|arteriosclerosis rs12242772; HDL cholesterol; cholesterol ester storage disease|cholesterol embolism|coronary artery disease |
PTM | Modification Sites |
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Phosphorylation (count: 31) (view all) | 113 EDLDQWLSEDDNHVA dbPAF
138 TGVMICAYLLHRGKF dbPAF 155 AQEALDFYGEVRTRD dbPAF 174 TIPSQRRYVYYYSYL dbPAF 176 PSQRRYVYYYSYLLK dbPAF 177 SQRRYVYYYSYLLKN dbPAF |
Acetylation (count: 4) | 125 HVAAIHCKAGKGRTG PLMD
128 AIHCKAGKGRTGVMI PLMD 402 DQHTQITKV****** PLMD 6 **MTAIIKEIVSRNK PLMD |
Ubiquitination (count: 4) | 13 KEIVSRNKRRYQEDG PLMD
289 GPEETSEKVENGSLC PLMD 6 **MTAIIKEIVSRNK PLMD 80 ERHYDTAKFNCRVAQ PLMD |
Sumoylation (count: 3) | 254 LPVCGDIKVEFFHKQ PLMD
266 HKQNKMLKKDKMFHF PLMD 289 GPEETSEKVENGSLC PLMD |
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