O95294

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession RASL1_HUMAN; O95294;
Entrez ID 8437
GenBank Protein ID NM_001193520.1; NM_001193521.1; NM_001301202.1; NM_004658.2; XM_005253950.4; XM_006719641.3; XM_011538852.2; XM_011538853.2; XM_017020028.1;
GenBank Nucleotide ID NP_001180449.1; NP_001180450.1; NP_001288131.1; NP_004649.2; XP_005254007.1; XP_006719704.1; XP_011537154.1; XP_011537155.1; XP_016875517.1;
Protein Name RasGAP-activating-like protein 1 (RAS protein activator like 1) (Ras GTPase-activating-like protein)
Gene Name RASAL1; RASAL
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionProbable inhibitory regulator of the Ras-cyclic AMP pathway (PubMed:9751798). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Sequence
(Fasta)		MAKSSSLNVR VVEGRALPAK DVSGSSDPYC LVKVDDEVVA RTATVWRSLG PFWGEEYTVH 60
LPLDFHQLAF YVLDEDTVGH DDIIGKISLS REAITADPRG IDSWINLSRV DPDAEVQGEI 120
CLSVQMLEDG QGRCLRCHVL QARDLAPRDI SGTSDPFARV FWGSQSLETS TIKKTRFPHW 180
DEVLELREMP GAPSPLRVEL WDWDMVGKND FLGMVEFSPK TLQQKPPKGW FRLLPFPRAE 240
EDSGGNLGAL RVKVRLIEDR VLPSQCYQPL MELLMESVQG PAEEDTASPL ALLEELTLGD 300
CRQDLATKLV KLFLGRGLAG RFLDYLTRRE VARTMDPNTL FRSNSLASKS MEQFMKLVGM 360
PYLHEVLKPV ISRVFEEKKY MELDPCKMDL GRTRRISFKG ALSEEQMRET SLGLLTGYLG 420
PIVDAIVGSV GRCPPAMRLA FKQLHRRVEE RFPQAEHQDV KYLAISGFLF LRFFAPAILT 480
PKLFDLRDQH ADPQTSRSLL LLAKAVQSIG NLGQQLGQGK ELWMAPLHPF LLQCVSRVRD 540
FLDRLVDVDG DEAGVPARAL FPPSAIVREG YLLKRKEEPA GLATRFAFKK RYVWLSGETL 600
SFSKSPEWQM CHSIPVSHIR AVERVDEGAF QLPHVMQVVT QDGTGALHTT YLQCKNVNEL 660
NQWLSALRKA SAPNPNKLAA CHPGAFRSAR WTCCLQAERS AAGCSRTHSA VTLGDWSDPL 720
DPDAEAQTVY RQLLLGRDQL RLKLLEDSNM DTTLEADTGA CPEVLARQRA ATARLLEVLA 780
DLDRAHEEFQ QQERGKAALG PLGP 805

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1MethylationGangliogliomaP24377515
[Reference]: Elevated expression of the RASAL1 protein, a decreased RAS-GTP and p-ERK1/2 protein were detected in three gastric cancer cell lines after treatment with 5-Aza-CdR
2MethylationChronic kidney diseaseP23975750
[Reference]: that they are more relevant to gene expression/activity than most SNPs and that methylomics may be a powerful tool for risk stratification of individual CKD patients in the future.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 1)		MESH:D007674 ; Kidney Diseases
GWASdb
(count: 4)		rs1732771; Cognitive test performance; cognitive disorder
rs7978582; Schizophrenia; schizophrenia
rs7964202; Lymphocyte counts; asthma|leukemia|lymphoma|lymphopenia|cardiovascular system disease
rs146551951; Prostate cancer (advanced); prostate cancer

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 5)		 397       LGRTRRISFKGALSE     dbPAF
4         ****MAKSSSLNVRV     dbPAF
44        EVVARTATVWRSLGP     dbPAF
5         ***MAKSSSLNVRVV     dbPAF
758       DTTLEADTGACPEVL     dbPAF
Acetylation
(count: 1)		 574       VREGYLLKRKEEPAG     PLMD
Ubiquitination
(count: 7)
(view all)		 174       LETSTIKKTRFPHWD     PLMD
349       RSNSLASKSMEQFMK     PLMD
399       RTRRISFKGALSEEQ     PLMD
482       APAILTPKLFDLRDQ     PLMD
504       RSLLLLAKAVQSIGN     PLMD
574       VREGYLLKRKEEPAG     PLMD