Q9H5I1

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession SUV92_HUMAN; Q9H5I1;
Entrez ID 79723
GenBank Protein ID NM_001193424.1; NM_001193425.1; NM_001193426.1; NM_001193427.1; NM_024670.3; XM_006717503.3; XM_011519662.2; XM_017016637.1;
GenBank Nucleotide ID NP_001180353.1; NP_001180354.1; NP_001180355.1; NP_001180356.1; NP_078946.1; XP_006717566.1; XP_011517964.1; XP_016872126.1;
Protein Name Histone-lysine N-methyltransferase SUV39H2 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Lysine N-methyltransferase 1B) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2)
Gene Name SUV39H2; KMT1B
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionHistone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repe(view all)
Sequence
(Fasta)		MAAVGAEARG AWCVPCLVSL DTLQELCRKE KLTCKSIGIT KRNLNNYEVE YLCDYKVVKD 60
MEYYLVKWKG WPDSTNTWEP LQNLKCPLLL QQFSNDKHNY LSQVKKGKAI TPKDNNKTLK 120
PAIAEYIVKK AKQRIALQRW QDELNRRKNH KGMIFVENTV DLEGPPSDFY YINEYKPAPG 180
ISLVNEATFG CSCTDCFFQK CCPAEAGVLL AYNKNQQIKI PPGTPIYECN SRCQCGPDCP 240
NRIVQKGTQY SLCIFRTSNG RGWGVKTLVK IKRMSFVMEY VGEVITSEEA ERRGQFYDNK 300
GITYLFDLDY ESDEFTVDAA RYGNVSHFVN HSCDPNLQVF NVFIDNLDTR LPRIALFSTR 360
TINAGEELTF DYQMKGSGDI SSDSIDHSPA KKRVRTVCKC GAVTCRGYLN 411

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1MethylationSkin thicknessD23891737
[Reference]: lobal histone H4 acetylation and the expression of HDAC2 were negatively correlated. Global histone H3K9 methylation and the expression of SUV39H2?protein?were positively correlated. Global H4 acetylation was positively correlated with?disease?activity and expression of HDAC2?protein?was negatively correlated with skin thickness.

※ Disease Cross-ref Annotation

DatabaseAnnotation
GWASdb
(count: 3)		rs17156034; Multiple complex diseases; Null
rs11594111; Migraine; migraine
rs11594111; Migraine without aura; migraine without aura

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 15)
(view all)		 111       VKKGKAITPKDNNKT     dbPAF
118       TPKDNNKTLKPAIAE     dbPAF
248       NRIVQKGTQYSLCIF     dbPAF
251       VQKGTQYSLCIFRTS     dbPAF
303       FYDNKGITYLFDLDY     dbPAF
310       TYLFDLDYESDEFTV     dbPAF
Acetylation
(count: 4)		 120       KDNNKTLKPAIAEYI     PLMD
129       AIAEYIVKKAKQRIA     PLMD
41        CKSIGITKRNLNNYE     PLMD
97        LQQFSNDKHNYLSQV     PLMD
Ubiquitination
(count: 5)		 129       AIAEYIVKKAKQRIA     PLMD
214       GVLLAYNKNQQIKIP     PLMD
56        VEYLCDYKVVKDMEY     PLMD
69        EYYLVKWKGWPDSTN     PLMD
97        LQQFSNDKHNYLSQV     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource