| Tag | Content |
|---|---|
| UniProt Accession | E41L3_HUMAN; Q9Y2J2; |
| Entrez ID | 23136 |
| GenBank Protein ID | NM_001281533.1; NM_001281534.1; NM_001281535.1; NM_012307.3; XM_017025636.1; |
| GenBank Nucleotide ID | NP_001268462.1; NP_001268463.1; NP_001268464.1; NP_036439.2; XP_016881125.1; |
| Protein Name | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] |
| Gene Name | EPB41L3; DAL1; KIAA0987 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. |
| Sequence (Fasta) | MTTESGSDSE SKPDQEAEPQ EAAGAQGRAG APVPEPPKEE QQQALEQFAA AAAHSTPVRR 60 EVTDKEQEFA ARAAKQLEYQ QLEDDKLSQK SSSSKLSRSP LKIVKKPKSM QCKVILLDGS 120 EYTCDVEKRS RGQVLFDKVC EHLNLLEKDY FGLTYRDAEN QKNWLDPAKE IKKQVRSGAW 180 HFSFNVKFYP PDPAQLSEDI TRYYLCLQLR DDIVSGRLPC SFVTLALLGS YTVQSELGDY 240 DPDECGSDYI SEFRFAPNHT KELEDKVIEL HKSHRGMTPA EAEMHFLENA KKLSMYGVDL 300 HHAKDSEGVE IMLGVCASGL LIYRDRLRIN RFAWPKVLKI SYKRNNFYIK IRPGEFEQFE 360 STIGFKLPNH RAAKRLWKVC VEHHTFFRLL LPEAPPKKFL TLGSKFRYSG RTQAQTRRAS 420 ALIDRPAPYF ERSSSKRYTM SRSLDGEVGT GQYATTKGIS QTNLITTVTP EKKAEEERDE 480 EEDKRRKGEE VTPISAIRHE GKSPGLGTDS CPLSPPSTHC APTSPTELRR RCKENDCKLP 540 GYEPSRAEHL PGEPALDSDG PGRPYLGDQD VAFSYRQQTG KGTTLFSFSL QLPESFPSLL 600 DDDGYLSFPN LSETNLLPQS LQHYLPIRSP SLVPCFLFIF FFLLSASFSV PYALTLSFPL 660 ALCLCYLEPK AASLSASLDN DPSDSSEEET DSERTDTAAD GETTATESDQ EEDAELKAQE 720 LEKTQDDLMK HQTNISELKR TFLETSTDTA VTNEWEKRLS TSPVRLAARQ EDAPMIEPLV 780 PEETKQSSGE KLMDGSEIFS LLESARKPTE FIGGVTSTSQ SWVQKMETKT ESSGIETEPT 840 VHHLPLSTEK VVQETVLVEE RRVVHASGDA SYSAGDSGDA AAQPAFTGIK GKEGSALTEG 900 AKEEGGEEVA KAVLEQEETA AASRERQEEQ SAAIHISETL EQKPHFESST VKTETISFGS 960 VSPGGVKLEI STKEVPVVHT ETKTITYESS QVDPGTDLEP GVLMSAQTIT SETTSTTTTT 1020 HITKTVKGGI SETRIEKRIV ITGDADIDHD QALAQAIKEA KEQHPDMSVT KVVVHKETEI 1080 TPEDGED 1088 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 1) | MESH:D001943 ; Breast Neoplasms |
| DisGeNet (Curated) (count: 1) | C1458155; Mammary Neoplasms |
| GWASdb (count: 20) (view all) | rs11661371; Suicide attempts in bipolar disorder; bipolar disorder
rs11661371; Vascular dementia; vascular dementia rs9965501; Body mass index; obesity rs12605370; Body mass index; obesity rs12605370; Suicide attempts in bipolar disorder; bipolar disorder rs6506299; Suicide attempts in bipolar disorder; bipolar disorder |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 57) (view all) | 1068 KEQHPDMSVTKVVVH dbPAF
1081 VHKETEITPEDGED* dbPAF 11 ESGSDSESKPDQEAE dbPAF 122 ILLDGSEYTCDVEKR dbPAF 123 LLDGSEYTCDVEKRS dbPAF 130 TCDVEKRSRGQVLFD dbPAF |
| Ubiquitination (count: 7) (view all) | 138 RGQVLFDKVCEHLNL PLMD
162 YRDAENQKNWLDPAK PLMD 266 HTKELEDKVIELHKS PLMD 336 INRFAWPKVLKISYK PLMD 397 LLPEAPPKKFLTLGS PLMD 398 LPEAPPKKFLTLGSK PLMD |
| Network | Interaction | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| A | B | Source | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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