| Tag | Content |
|---|---|
| UniProt Accession | BNIP3_HUMAN; Q12983; |
| Entrez ID | 664 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 |
| Gene Name | BNIP3; NIP3 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. |
| Sequence (Fasta) | MGDAAADPPG PALPCEFLRP GCGAPLSPGA QLGRGAPTSA FPPPAAEAHP AARRGLRSPQ 60 LPSGAMSQNG APGMQEESLQ GSWVELHFSN NGNGGSVPAS VSIYNGDMEK ILLDAQHESG 120 RSSSKSSHCD SPPRSQTPQD TNRASETDTH SIGEKNSSQS EEDDIERRKE VESILKKNSD 180 WIWDWSSRPE NIPPKEFLFK HPKRTATLSM RNTSVMKKGG IFSAEFLKVF LPSLLLSHLL 240 AIGLGIYIGR RLTTSTSTF |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 4) | MESH:D020149
; Manganese Poisoning MESH:D009101 ; Multiple Myeloma MESH:D011471 ; Prostatic Neoplasms MESH:D013274 ; Stomach Neoplasms |
| GWASdb (count: 1) | rs9419390; Type 2 diabetes; type 2 diabetes mellitus |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 29) (view all) | 140 LFKHPKRTATLSMRN dbPAF
142 KHPKRTATLSMRNTS dbPAF 144 PKRTATLSMRNTSVM dbPAF 148 ATLSMRNTSVMKKGG dbPAF 149 TLSMRNTSVMKKGGI dbPAF 17 QEESLQGSWVELHFS dbPAF |
| Ubiquitination (count: 6) | 104 EDDIERRKEVESILK PLMD
111 KEVESILKKNSDWIW PLMD 135 PPKEFLFKHPKRTAT PLMD 152 MRNTSVMKKGGIFSA PLMD 153 RNTSVMKKGGIFSAE PLMD 90 DTHSIGEKNSSQSEE PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |