P42336

※ Protein Information

Tag	Content
UniProt Accession	PK3CA_HUMAN; P42336;
Entrez ID	5290
GenBank Protein ID	NM_006218.3; XM_006713658.3; XM_011512894.2;
GenBank Nucleotide ID	NP_006209.2; XP_006713721.1; XP_011511196.1;
Protein Name	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alp
Gene Name	PIK3CA
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the(view all) Functional Description Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Also has serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS. Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity).
Sequence (Fasta)	MPPRPSSGEL WGIHLMPPRI LVECLLPNGM IVTLECLREA TLITIKHELF KEARKYPLHQ 60 LLQDESSYIF VSVTQEAERE EFFDETRRLC DLRLFQPFLK VIEPVGNREE KILNREIGFA 120 IGMPVCEFDM VKDPEVQDFR RNILNVCKEA VDLRDLNSPH SRAMYVYPPN VESSPELPKH 180 IYNKLDKGQI IVVIWVIVSP NNDKQKYTLK INHDCVPEQV IAEAIRKKTR SMLLSSEQLK 240 LCVLEYQGKY ILKVCGCDEY FLEKYPLSQY KYIRSCIMLG RMPNLMLMAK ESLYSQLPMD 300 CFTMPSYSRR ISTATPYMNG ETSTKSLWVI NSALRIKILC ATYVNVNIRD IDKIYVRTGI 360 YHGGEPLCDN VNTQRVPCSN PRWNEWLNYD IYIPDLPRAA RLCLSICSVK GRKGAKEEHC 420 PLAWGNINLF DYTDTLVSGK MALNLWPVPH GLEDLLNPIG VTGSNPNKET PCLELEFDWF 480 SSVVKFPDMS VIEEHANWSV SREAGFSYSH AGLSNRLARD NELRENDKEQ LKAISTRDPL 540 SEITEQEKDF LWSHRHYCVT IPEILPKLLL SVKWNSRDEV AQMYCLVKDW PPIKPEQAME 600 LLDCNYPDPM VRGFAVRCLE KYLTDDKLSQ YLIQLVQVLK YEQYLDNLLV RFLLKKALTN 660 QRIGHFFFWH LKSEMHNKTV SQRFGLLLES YCRACGMYLK HLNRQVEAME KLINLTDILK 720 QEKKDETQKV QMKFLVEQMR RPDFMDALQG FLSPLNPAHQ LGNLRLEECR IMSSAKRPLW 780 LNWENPDIMS ELLFQNNEII FKNGDDLRQD MLTLQIIRIM ENIWQNQGLD LRMLPYGCLS 840 IGDCVGLIEV VRNSHTIMQI QCKGGLKGAL QFNSHTLHQW LKDKNKGEIY DAAIDLFTRS 900 CAGYCVATFI LGIGDRHNSN IMVKDDGQLF HIDFGHFLDH KKKKFGYKRE RVPFVLTQDF 960 LIVISKGAQE CTKTREFERF QEMCYKAYLA IRQHANLFIN LFSMMLGSGM PELQSFDDIA 1020 YIRKTLALDK TEQEALEYFM KQMNDAHHGG WTTKMDWIFH TIKQHALN 1069 Fasta Sequence >P42336\|PIK3CA\|Homo sapiens (Human) MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Methylation	Gastric cancer		P		24513424
1	[Reference]: We demonstrated PIK3CA gene was specifically amplified in gastric cancers, but not in normal gastric tissues. Moreover, frequent methylation of RASSF1A and PAX6 was also found in gastric cancers

※ Disease Cross-ref Annotation

Database	Annotation
Cancer Gene Census	colorectal, gastric, glioblastoma, breast
CTD (Curated) (count: 31) (view all)	MESH:D000230 ; Adenocarcinoma MESH:C562730 ; Adenocarcinoma Of Esophagus MESH:C538231 ; Adenocarcinoma of lung MESH:D001943 ; Breast Neoplasms MESH:D003528 ; Carcinoma, Adenoid Cystic MESH:D002280 ; Carcinoma, Basal Cell MESH:D006528 ; Carcinoma, Hepatocellular MESH:D002292 ; Carcinoma, Renal Cell MESH:D002294 ; Carcinoma, Squamous Cell MESH:C535575 ; Carcinoma, squamous cell of head and neck MESH:D015179 ; Colorectal Neoplasms MESH:C567863 ; Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal Nevi MESH:C567337 ; Cowden-Like Syndrome MESH:D018450 ; Disease Progression MESH:C580062 ; Epidermal Nevus MESH:D006130 ; Growth Disorders MESH:D006965 ; Hyperplasia MESH:D017492 ; Keratosis, Seborrheic MESH:D008175 ; Lung Neoplasms MESH:D016403 ; Lymphoma, Large B-Cell, Diffuse MESH:D054220 ; Malformations of Cortical Development MESH:C566381 ; Megalancephaly Polymicrogyria-Polydactyly Hydrocephalus Syndrome MESH:D009062 ; Mouth Neoplasms MESH:C538339 ; Nasopharyngeal carcinoma MESH:D009362 ; Neoplasm Metastasis MESH:D010051 ; Ovarian Neoplasms MESH:D010412 ; Penile Neoplasms MESH:D011471 ; Prostatic Neoplasms MESH:D012509 ; Sarcoma MESH:D013274 ; Stomach Neoplasms MESH:D015430 ; Weight Gain
GWASdb (count: 3)	rs17592582; Alcohol dependence; alcohol dependence rs3729693; Triglycerides; coronary artery disease\|lipid metabolism disorder\|arteriosclerosis rs3729693; HDL cholesterol; cholesterol ester storage disease\|cholesterol embolism\|coronary artery disease

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 19) (view all)	1038 TEQEALEYFMKQMND dbPAF 246 LKLCVLEYQGKYILK dbPAF 294 LMAKESLYSQLPMDC dbPAF 306 MDCFTMPSYSRRIST dbPAF 312 PSYSRRISTATPYMN dbPAF 313 SYSRRISTATPYMNG dbPAF 315 SRRISTATPYMNGET dbPAF 317 RISTATPYMNGETST dbPAF 332 KSLWVINSALRIKIL dbPAF 355 IRDIDKIYVRTGIYH dbPAF 361 IYVRTGIYHGGEPLC dbPAF 507 VSREAGFSYSHAGLS dbPAF 508 SREAGFSYSHAGLSN dbPAF 509 REAGFSYSHAGLSNR dbPAF 584 RDEVAQMYCLVKDWP dbPAF 698 YCRACGMYLKHLNRQ dbPAF 874 KGALQFNSHTLHQWL dbPAF 876 ALQFNSHTLHQWLKD dbPAF 957 ERVPFVLTQDFLIVI dbPAF
Acetylation (count: 2)	111 PVGNREEKILNREIG PLMD 863 TIMQIQCKGGLKGAL PLMD
Ubiquitination (count: 2)	100 RLFQPFLKVIEPVGN PLMD 863 TIMQIQCKGGLKGAL PLMD
Glycation (count: 2)	941 FGHFLDHKKKKFGYK PLMD 942 GHFLDHKKKKFGYKR PLMD

※ Protein-Protein Interaction

Network

Interaction

Source

F5GXJ0	P42336	IntAct
O00459	P42336	IntAct
O14654	P42336	HPRD
O14807	P42336	HPRD
O75190	P42336	IntAct
P01111	P42336	HPRD
P01112	P42336	HPRD
P02760	P42336	IntAct
P02792	P42336	IntAct
P06239	P42336	HPRD
P08700	P42336	HPRD
P09619	P42336	HPRD
P17844	P42336	IntAct
P18505	P42336	HPRD
P19827	P42336	IntAct
P21860	P42336	IntAct
P22681	P42336	IntAct
P23443	P42336	HPRD
P27986	P42336	HPRD; DIP; MINT
P35568	P42336	MINT
P42336	P50148	HPRD
P42336	P60866	IntAct
P42336	P62993	IntAct
P42336	Q05655	HPRD
P42336	Q06481	HPRD
P42336	Q13224	HPRD
P42336	Q13501	IntAct
P42336	Q14511	IntAct
P42336	Q8IUC6	HPRD
P42336	Q92569	HPRD
P42336	Q92890	IntAct
P42336	Q96B97	HPRD
P42336	Q96D21	HPRD
P42336	Q9UII2	IntAct
P42336	Q9UKG1	HPRD
P42336	Q9Y4H2	HPRD

PTMD Annotation Information

※ Protein Information

Functional Description

Fasta Sequence

※ PTM-Disease Association

※ Disease Cross-ref Annotation

※ PTM Sites

※ Protein-Protein Interaction