P67775

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession PP2AA_HUMAN; P67775;
Entrez ID 5515
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C)
Gene Name PPP2CA
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionPP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.
Sequence
(Fasta)		MDEKVFTKEL DQWIEQLNEC KQLSESQVKS LCEKAKEILT KESNVQEVRC PVTVCGDVHG 60
QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYRER ITILRGNHES 120
RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL SPSIDTLDHI 180
RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA 240
HQLVMEGYNW CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV 300
TRRTPDYFL

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1MethylationNeurodegenerative diseaseD3057931; 21044074
[Reference]: Expression of protein phosphatase methylesterase 1 and the methylation-site L309 C subunit mutant, which decrease intracellular methylated C and B levels, block N2a cell differentiation and LCMT1-mediated neurite formation. Lastly, inducible and non-inducible knockdown of B in N2a cells inhibit process outgrowth. Altogether, our results establish a novel mechanistic link between PP2A methylation and development of neurite-like processes.
2MethylationAlzheimer's diseaseD17360897
[Reference]: Here, we show that incubation of neuroblastoma cells with S-adenosylhomocysteine results in reduced methylation of protein phosphatase 2A (PP2A), a major brain Ser/Thr phosphatase, most likely by inhibiting PP2A methyltransferase (PPMT).
3Tyrosine PhosphorylationAlzheimer's diseaseUY30718208556
[Reference]: Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology.
4Tyrosine PhosphorylationColon cancer/carcinomaUY30725003662
[Reference]: Protein phosphatase 2A (PP2A) is a tumour suppressor frequently inactivated in human cancer and its tyrosine-307 phosphorylation has been reported as a molecular inhibitory mechanism.
5Tyrosine PhosphorylationChronic myelogenous leukemia/Chronic myeloid leukemiaUY30721490338
[Reference]: We next analyzed PP2A phosphorylation status in CD34+ cells from patients in these response groups and found elevated levels of pY307-PP2A in cells from the CCR and No-CCR response groups but dramatically increased levels of this phosphoprotein in cells from patients destined to progress
6Leucine MethylationAlzheimer's diseasePL30924653673
[Reference]: Significantly, alterations in one-carbon metabolism that impair PP2A methylation are associated with increased risk for sporadic AD, and enhanced AD-like pathology in animal models

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 3)		MESH:D001249 ; Asthma
MESH:D006331 ; Heart Diseases
MESH:D017202 ; Myocardial Ischemia
GWASdb
(count: 1)		rs13187105; Pulmonary function in asthmatics; asthma

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 5)		 248       HQLVMEGYNWCHDRN     dbPAF
265       TIFSAPNYCYRCGNQ     dbPAF
284       ELDDTLKYSFLQFDP     dbPAF
304       EPHVTRRTPDYFL**     dbPAF
307       VTRRTPDYFL*****     dbPAF
Acetylation
(count: 3)		 29        QLSESQVKSLCEKAK     PLMD
36        KSLCEKAKEILTKES     PLMD
4         ****MDEKVFTKELD     PLMD
Ubiquitination
(count: 6)		 21        IEQLNECKQLSESQV     PLMD
29        QLSESQVKSLCEKAK     PLMD
34        QVKSLCEKAKEILTK     PLMD
36        KSLCEKAKEILTKES     PLMD
4         ****MDEKVFTKELD     PLMD
8         MDEKVFTKELDQWIE     PLMD
Sumoylation
(count: 1)		 4         ****MDEKVFTKELD     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource
B1AP70P67775BioGRID
D6RBW1P67775MINT
F5GWR8P67775HPRD
F5GWV1P67775MINT
F8VWG6P67775IntAct
F8VYA6P67775IntAct
G3V1V9P67775HPRD
H0YN26P67775MINT
H7BXK2P67775BioGRID
H7BYL5P67775MINT
O00238P67775HPRD
O00506P67775IntAct
O15169P67775HPRD
O43318P67775MINT
O43524P67775MINT
O43815P67775HPRD; IntAct;IntAct
O60674P67775HPRD
O75145P67775IntAct
O95166P67775IntAct
O95684P67775IntAct
P01106P67775MINT
P01760P67775BioGRID
P04049P67775MINT
P04114P67775BioGRID
P04637P67775HPRD
P05412P67775MINT
P06400P67775MINT
P07992P67775BioGRID
P08100P67775HPRD
P10301P67775HPRD
P10415P67775HPRD; MINT
P10636P67775HPRD
P12931P67775MINT
P13639P67775HPRD
P17987P67775IntAct
P21246P67775HPRD; IntAct; MINT
P23443P67775HPRD; MINT
P23528P67775DIP
P24071P67775HPRD
P25025P67775HPRD
P25054P67775HPRD
P27361P67775HPRD; MINT
P27708P67775HPRD
P28472P67775HPRD
P28482P67775HPRD; MINT
P28749P67775MINT
P30153P67775HPRD; DIP; IntAct
P30154P67775IntAct;HPRD
P31314P67775HPRD
P31749P67775HPRD; MINT
P35579P67775IntAct
P38606P67775BioGRID
P40145P67775HPRD
P40227P67775IntAct
P42229P67775HPRD
P42773P67775IntAct
P45973P67775IntAct
P45983P67775MINT
P45984P67775MINT
P46695P67775MINT
P48643P67775IntAct
P49023P67775HPRD
P49368P67775IntAct
P49815P67775HPRD
P49841P67775MINT
P50748P67775BioGRID
P50990P67775IntAct
P50991P67775IntAct
P51692P67775HPRD
P51959P67775HPRD
P57058P67775DIP
P62136P67775HPRD
P62495P67775HPRD
P62745P67775HPRD
P63151P67775HPRD; IntAct; MINT
P67775P78318HPRD; IntAct; MINT
P67775P78371IntAct
P67775P80188BioGRID
P67775Q00005IntAct
P67775Q01105HPRD
P67775Q02241MINT
P67775Q03692BioGRID
P67775Q04206HPRD; MINT
P67775Q05655HPRD
P67775Q08379HPRD
P67775Q08999MINT
P67775Q09470BioGRID
P67775Q13033IntAct
P67775Q13136IntAct
P67775Q13362HPRD; IntAct; MINT
P67775Q13541HPRD
P67775Q14738IntAct
P67775Q14BN4IntAct
P67775Q15172IntAct; MINT
P67775Q15173HPRD; IntAct; MINT
P67775Q15257IntAct
P67775Q15645HPRD; IntAct; MINT
P67775Q16537HPRD; IntAct
P67775Q16589HPRD
P67775Q32Q12HPRD
P67775Q562F6HPRD; IntAct
P67775Q5FBB7HPRD; IntAct;IntAct
P67775Q5THK1IntAct
P67775Q5VSL9IntAct
P67775Q66LE6IntAct
P67775Q6DKJ4HPRD; MINT
P67775Q6VY07HPRD
P67775Q7LBC6BioGRID
P67775Q86XL3IntAct
P67775Q86YF9MINT
P67775Q8N201MINT
P67775Q8WZ74IntAct
P67775Q969F8MINT
P67775Q969G9IntAct
P67775Q96DA6MINT
P67775Q99250HPRD
P67775Q99259HPRD
P67775Q99832IntAct
P67775Q9BRV8IntAct
P67775Q9BUB5MINT
P67775Q9BUL8IntAct
P67775Q9BWN1IntAct
P67775Q9BYN8HPRD; IntAct; MINT
P67775Q9H0H5HPRD; MINT
P67775Q9H0K1IntAct
P67775Q9H0R8IntAct
P67775Q9H7D0IntAct
P67775Q9NPH2HPRD; IntAct; MINT
P67775Q9NRL3IntAct
P67775Q9P0W5IntAct
P67775Q9P289IntAct
P67775Q9P2B4IntAct
P67775Q9Y228IntAct
P67775Q9Y2T4IntAct
P67775Q9Y3A3IntAct
P67775Q9Y570IntAct
P67775Q9Y5P8IntAct
P67775Q9Y6E0IntAct