| Tag | Content |
|---|---|
| UniProt Accession | COPD_HUMAN; P48444; |
| Entrez ID | 372 |
| GenBank Protein ID | NM_001142281.1; NM_001655.4; |
| GenBank Nucleotide ID | NP_001135753.1; NP_001646.2; |
| Protein Name | Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) |
| Gene Name | ARCN1; COPD |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). |
| Sequence (Fasta) | MVLLAAAVCT KAGKAIVSRQ FVEMTRTRIE GLLAAFPKLM NTGKQHTFVE TESVRYVYQP 60 MEKLYMVLIT TKNSNILEDL ETLRLFSRVI PEYCRALEEN EISEHCFDLI FAFDEIVALG 120 YRENVNLAQI RTFTEMDSHE EKVFRAVRET QEREAKAEMR RKAKELQQAR RDAERQGKKA 180 PGFGGFGSSA VSGGSTAAMI TETIIETDKP KVAPAPARPS GPSKALKLGA KGKEVDNFVD 240 KLKSEGETIM SSSMGKRTSE ATKMHAPPIN MESVHMKIEE KITLTCGRDG GLQNMELHGM 300 IMLRISDDKY GRIRLHVENE DKKGVQLQTH PNVDKKLFTA ESLIGLKNPE KSFPVNSDVG 360 VLKWRLQTTE ESFIPLTINC WPSESGNGCD VNIEYELQED NLELNDVVIT IPLPSGVGAP 420 VIGEIDGEYR HDSRRNTLEW CLPVIDAKNK SGSLEFSIAG QPNDFFPVQV SFVSKKNYCN 480 IQVTKVTQVD GNSPVRFSTE TTFLVDKYEI L 512 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 1) | MESH:D001259 ; Ataxia |
| DisGeNet (Curated) (count: 1) | C0004134; Ataxia |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 25) (view all) | 132 VNLAQIRTFTEMDSH dbPAF
134 LAQIRTFTEMDSHEE dbPAF 138 RTFTEMDSHEEKVFR dbPAF 18 KAGKAIVSRQFVEMT dbPAF 189 GFGGFGSSAVSGGST dbPAF 192 GFGSSAVSGGSTAAM dbPAF |
| Acetylation (count: 14) (view all) | 14 AVCTKAGKAIVSRQF PLMD
142 EMDSHEEKVFRAVRE PLMD 211 IIETDKPKVAPAPAR PLMD 224 ARPSGPSKALKLGAK PLMD 231 KALKLGAKGKEVDNF PLMD 233 LKLGAKGKEVDNFVD PLMD |
| Ubiquitination (count: 22) (view all) | 142 EMDSHEEKVFRAVRE PLMD
164 AEMRRKAKELQQARR PLMD 179 DAERQGKKAPGFGGF PLMD 211 IIETDKPKVAPAPAR PLMD 224 ARPSGPSKALKLGAK PLMD 233 LKLGAKGKEVDNFVD PLMD |
| Malonylation (count: 3) | 142 EMDSHEEKVFRAVRE PLMD
241 EVDNFVDKLKSEGET PLMD 351 IGLKNPEKSFPVNSD PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |