Tag | Content |
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UniProt Accession | RASF1_HUMAN; Q9NS23; |
Entrez ID | 11186 |
GenBank Protein ID | NM_001206957.1; NM_007182.4; NM_170712.2; NM_170713.2; NM_170714.1; XM_011533315.1; XM_011533316.2; |
GenBank Nucleotide ID | NP_001193886.1; NP_009113.3; NP_733830.1; NP_733831.1; NP_733832.1; XP_011531617.1; XP_011531618.1; |
Protein Name | Ras association domain-containing protein 1 |
Gene Name | RASSF1; RDA32 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage. |
Sequence (Fasta) | MSGEPELIEL RELAPAGRAG KGRTRLERAN ALRIARGTAC NPTRQLVPGR GHRFQPAGPA 60 THTWCDLCGD FIWGVVRKGL QCARLSADCK FTCHYRCRAL VCLDCCGPRD LGWEPAVERD 120 TNVDEPVEWE TPDLSQAEIE QKIKEYNAQI NSNLFMSLNK DGSYTGFIKV QLKLVRPVSV 180 PSSKKPPSLQ DARRGPGRGT SVRRRTSFYL PKDAVKHLHV LSRTRAREVI EALLRKFLVV 240 DDPRKFALFE RAERHGQVYL RKLLDDEQPL RLRLLAGPSD KALSFVLKEN DSGEVNWDAF 300 SMPELHNFLR ILQREEEEHL RQILQKYSYC RQKIQEALHA CPLG 345 |
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Database | Annotation |
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CTD (Curated) (count: 12) (view all) | MESH:D000230
; Adenocarcinoma MESH:D002312 ; Cardiomyopathy, Hypertrophic MESH:D015212 ; Inflammatory Bowel Diseases MESH:D008175 ; Lung Neoplasms MESH:D015674 ; Mammary Neoplasms, Animal MESH:D008527 ; Medulloblastoma |
DisGeNet (Curated) (count: 14) (view all) | C0001418; Adenocarcinoma
C0005686; Urinary Bladder Diseases C0005695; Bladder Neoplasm C0007120; Bronchioloalveolar Adenocarcinoma C0007131; Non-Small Cell Lung Carcinoma C0007194; Hypertrophic Cardiomyopathy |
HGMD (count: 1) | CM063088; Lung cancer, increased risk, association with; Missense/nonsense
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PTM | Modification Sites |
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Phosphorylation (count: 14) (view all) | 135 EWETPDLSQAEIEQK dbPAF
179 LKLVRPVSVPSSKKP dbPAF 182 VRPVSVPSSKKPPSL dbPAF 183 RPVSVPSSKKPPSLQ dbPAF 188 PSSKKPPSLQDARRG dbPAF 2 ******MSGEPELIE dbPAF |
Ubiquitination (count: 7) (view all) | 144 AEIEQKIKEYNAQIN PLMD
160 NLFMSLNKDGSYTGF PLMD 216 YLPKDAVKHLHVLSR PLMD 236 VIEALLRKFLVVDDP PLMD 262 HGQVYLRKLLDDEQP PLMD 281 LLAGPSDKALSFVLK PLMD |
Network | Interaction | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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