Tag | Content |
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UniProt Accession | SLIT2_HUMAN; O94813; |
Entrez ID | 9353 |
GenBank Protein ID | NM_001289135.2; NM_001289136.2; NM_004787.3; |
GenBank Nucleotide ID | NP_001276064.1; NP_001276065.1; NP_004778.1; |
Protein Name | Slit homolog 2 protein (Slit-2) [Cleaved into: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product] |
Gene Name | SLIT2; SLIL3 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissur(view all) |
Sequence (Fasta) | MRGVGWQMLS LSLGLVLAIL NKVAPQACPA QCSCSGSTVD CHGLALRSVP RNIPRNTERL 60 DLNGNNITRI TKTDFAGLRH LRVLQLMENK ISTIERGAFQ DLKELERLRL NRNHLQLFPE 120 LLFLGTAKLY RLDLSENQIQ AIPRKAFRGA VDIKNLQLDY NQISCIEDGA FRALRDLEVL 180 TLNNNNITRL SVASFNHMPK LRTFRLHSNN LYCDCHLAWL SDWLRQRPRV GLYTQCMGPS 240 HLRGHNVAEV QKREFVCSGH QSFMAPSCSV LHCPAACTCS NNIVDCRGKG LTEIPTNLPE 300 TITEIRLEQN TIKVIPPGAF SPYKKLRRID LSNNQISELA PDAFQGLRSL NSLVLYGNKI 360 TELPKSLFEG LFSLQLLLLN ANKINCLRVD AFQDLHNLNL LSLYDNKLQT IAKGTFSPLR 420 AIQTMHLAQN PFICDCHLKW LADYLHTNPI ETSGARCTSP RRLANKRIGQ IKSKKFRCSA 480 KEQYFIPGTE DYRSKLSGDC FADLACPEKC RCEGTTVDCS NQKLNKIPEH IPQYTAELRL 540 NNNEFTVLEA TGIFKKLPQL RKINFSNNKI TDIEEGAFEG ASGVNEILLT SNRLENVQHK 600 MFKGLESLKT LMLRSNRITC VGNDSFIGLS SVRLLSLYDN QITTVAPGAF DTLHSLSTLN 660 LLANPFNCNC YLAWLGEWLR KKRIVTGNPR CQKPYFLKEI PIQDVAIQDF TCDDGNDDNS 720 CSPLSRCPTE CTCLDTVVRC SNKGLKVLPK GIPRDVTELY LDGNQFTLVP KELSNYKHLT 780 LIDLSNNRIS TLSNQSFSNM TQLLTLILSY NRLRCIPPRT FDGLKSLRLL SLHGNDISVV 840 PEGAFNDLSA LSHLAIGANP LYCDCNMQWL SDWVKSEYKE PGIARCAGPG EMADKLLLTT 900 PSKKFTCQGP VDVNILAKCN PCLSNPCKND GTCNSDPVDF YRCTCPYGFK GQDCDVPIHA 960 CISNPCKHGG TCHLKEGEED GFWCICADGF EGENCEVNVD DCEDNDCENN STCVDGINNY 1020 TCLCPPEYTG ELCEEKLDFC AQDLNPCQHD SKCILTPKGF KCDCTPGYVG EHCDIDFDDC 1080 QDNKCKNGAH CTDAVNGYTC ICPEGYSGLF CEFSPPMVLP RTSPCDNFDC QNGAQCIVRI 1140 NEPICQCLPG YQGEKCEKLV SVNFINKESY LQIPSAKVRP QTNITLQIAT DEDSGILLYK 1200 GDKDHIAVEL YRGRVRASYD TGSHPASAIY SVETINDGNF HIVELLALDQ SLSLSVDGGN 1260 PKIITNLSKQ STLNFDSPLY VGGMPGKSNV ASLRQAPGQN GTSFHGCIRN LYINSELQDF 1320 QKVPMQTGIL PGCEPCHKKV CAHGTCQPSS QAGFTCECQE GWMGPLCDQR TNDPCLGNKC 1380 VHGTCLPINA FSYSCKCLEG HGGVLCDEEE DLFNPCQAIK CKHGKCRLSG LGQPYCECSS 1440 GYTGDSCDRE ISCRGERIRD YYQKQQGYAA CQTTKKVSRL ECRGGCAGGQ CCGPLRSKRR 1500 KYSFECTDGS SFVDEVEKVV KCGCTRCVS |
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Database | Annotation |
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CTD (Curated) (count: 3) | MESH:D006528
; Carcinoma, Hepatocellular MESH:D004833 ; Epilepsy, Temporal Lobe MESH:D055752 ; Small Cell Lung Carcinoma |
GWASdb (count: 27) (view all) | rs500869; Urinary metabolites; kidney disease
rs715213; Blood pressure (response to angiotensin-converting enzyme inhibitor); hypertension rs17609702; Type 2 diabetes; type 2 diabetes mellitus rs6849536; Brain lesion load; multiple sclerosis rs666088; Echocardiographic traits; cardiovascular system disease rs522501; Triglycerides; coronary artery disease|lipid metabolism disorder|arteriosclerosis |
PTM | Modification Sites |
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Phosphorylation (count: 5) | 135 KLYRLDLSENQIQAI dbPAF
1510 SFECTDGSSFVDEVE dbPAF 484 RCSAKEQYFIPGTED dbPAF 489 EQYFIPGTEDYRSKL dbPAF 492 FIPGTEDYRSKLSGD dbPAF |
Ubiquitination (count: 2) | 289 NIVDCRGKGLTEIPT PLMD
72 NNITRITKTDFAGLR PLMD |
Network | Interaction | ||
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A | B | Source | |