Q13761

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession RUNX3_HUMAN; Q13761;
Entrez ID 864
GenBank Protein ID NM_001031680.2; NM_001320672.1; NM_004350.2; XM_005246024.4;
GenBank Nucleotide ID NP_001026850.1; NP_001307601.1; NP_004341.1; XP_005246081.1;
Protein Name Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 a
Gene Name RUNX3; AML2; CBFA3; PEBP2A3
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionCBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters. In association with ZFHX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712).
Sequence
(Fasta)		MRIPVDPSTS RRFTPPSPAF PCGGGGGKMG ENSGALSAQA AVGPGGRARP EVRSMVDVLA 60
DHAGELVRTD SPNFLCSVLP SHWRCNKTLP VAFKVVALGD VPDGTVVTVM AGNDENYSAE 120
LRNASAVMKN QVARFNDLRF VGRSGRGKSF TLTITVFTNP TQVATYHRAI KVTVDGPREP 180
RRHRQKLEDQ TKPFPDRFGD LERLRMRVTP STPSPRGSLS TTSHFSSQPQ TPIQGTSELN 240
PFSDPRQFDR SFPTLPTLTE SRFPDPRMHY PGAMSAAFPY SATPSGTSIS SLSVAGMPAT 300
SRFHHTYLPP PYPGAPQNQS GPFQANPSPY HLYYGTSSGS YQFSMVAGSS SGGDRSPTRM 360
LASCTSSAAS VAAGNLMNPS LGGQSDGVEA DGSHSNSPTA LSTPGRMDEA VWRPY 416

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1MethylationGastric cancerP20485621; 2871588
[Reference]: Methylation of the tumor suppressor gene RUNX3 might be one of the mechanisms involved in the pathogenesis of gastric

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 11)
(view all)		MESH:D000230 ; Adenocarcinoma
MESH:D006528 ; Carcinoma, Hepatocellular
MESH:D002446 ; Celiac Disease
MESH:D004938 ; Esophageal Neoplasms
MESH:D005909 ; Glioblastoma
MESH:D015470 ; Leukemia, Myeloid, Acute
GWASdb
(count: 4)		rs2236851; Taste perception; sensory system disease
rs7551188; Crohn's disease; Crohn's disease
rs876109; Alzheimer's disease; Alzheimer's disease
rs72657048; Celiac disease; celiac disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 20)
(view all)		 14        PSTSRRFTPPSPAFP     dbPAF
149       GRSGRGKSFTLTITV     dbPAF
151       SGRGKSFTLTITVFT     dbPAF
153       RGKSFTLTITVFTNP     dbPAF
155       KSFTLTITVFTNPTQ     dbPAF
17        SRRFTPPSPAFPCGG     dbPAF
Acetylation
(count: 4)		 129       RNASAVMKNQVARFN     PLMD
186       EPRRHRQKLEDQTKP     PLMD
192       QKLEDQTKPFPDRFG     PLMD
28        PCGGGGGKMGENSGA     PLMD
Ubiquitination
(count: 3)		 129       RNASAVMKNQVARFN     PLMD
186       EPRRHRQKLEDQTKP     PLMD
192       QKLEDQTKPFPDRFG     PLMD
Sumoylation
(count: 1)		 192       QKLEDQTKPFPDRFG     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource