P13640

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession MT1G_HUMAN; P13640;
Entrez ID 4495
GenBank Protein ID NM_001301267.1; NM_005950.2;
GenBank Nucleotide ID NP_001288196.1; NP_005941.1;
Protein Name Metallothionein-1G (MT-1G) (Metallothionein-1K) (MT-1K) (Metallothionein-IG) (MT-IG)
Gene Name MT1G; MT1K; MT1M
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionMetallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Sequence
(Fasta)		MDPNCSCAAA GVSCTCASSC KCKECKCTSC KKSCCSCCPV GCAKCAQGCI CKGASEKCSC 60
CA 63

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1MethylationThyroid cancer/carcinomaP24098937
[Reference]: These data suggested that MT1G was more frequently methylated in thyroid cancer tissues compared with non-malignant thyroid tissues

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 1)		MESH:D004938 ; Esophageal Neoplasms
DisGeNet (Curated)
(count: 1)		C0014859; Esophageal Neoplasms

※ PTM Sites

PTM Modification Sites
Ubiquitination
(count: 1)		 23        CASSCKCKECKCTSC     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource