| Tag | Content |
|---|---|
| UniProt Accession | FUS_HUMAN; P35637; |
| Entrez ID | 2521 |
| GenBank Protein ID | NM_001170634.1; NM_004960.3; |
| GenBank Nucleotide ID | NP_001164105.1; NP_004951.1; |
| Protein Name | RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein) |
| Gene Name | FUS; TLS |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity. |
| Sequence (Fasta) | MASNDYTQQA TQSYGAYPTQ PGQGYSQQSS QPYGQQSYSG YSQSTDTSGY GQSSYSSYGQ 60 SQNTGYGTQS TPQGYGSTGG YGSSQSSQSS YGQQSSYPGY GQQPAPSSTS GSYGSSSQSS 120 SYGQPQSGSY SQQPSYGGQQ QSYGQQQSYN PPQGYGQQNQ YNSSSGGGGG GGGGGNYGQD 180 QSSMSSGGGS GGGYGNQDQS GGGGSGGYGQ QDRGGRGRGG SGGGGGGGGG GYNRSSGGYE 240 PRGRGGGRGG RGGMGGSDRG GFNKFGGPRD QGSRHDSEQD NSDNNTIFVQ GLGENVTIES 300 VADYFKQIGI IKTNKKTGQP MINLYTDRET GKLKGEATVS FDDPPSAKAA IDWFDGKEFS 360 GNPIKVSFAT RRADFNRGGG NGRGGRGRGG PMGRGGYGGG GSGGGGRGGF PSGGGGGGGQ 420 QRAGDWKCPN PTCENMNFSW RNECNQCKAP KPDGPGGGPG GSHMGGNYGD DRRGGRGGYD 480 RGGYRGRGGD RGGFRGGRGG GDRGGFGPGK MDSRGEHRQD RRERPY 527 |
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| Database | Annotation |
|---|---|
| Cancer Gene Census | liposarcoma, AML, Ewing sarcoma, angiomatoid fibrous histiocytoma, fibromyxoid sarcoma |
| CTD (Curated) (count: 3) | MESH:C567699
; Amyotrophic Lateral Sclerosis 6, Autosomal Recessive MESH:D018208 ; Liposarcoma, Myxoid OMIM:614782 ; TREMOR, HEREDITARY ESSENTIAL, 4 |
| DisGeNet (Curated) (count: 43) (view all) | C0002736; Amyotrophic Lateral Sclerosis
C0003467; Anxiety C0011581; Depressive disorder C0013362; Dysarthria C0013404; Dyspnea C0015644; Muscular fasciculation |
| HGMD (count: 14) (view all) | CD092246; Amyotrophic lateral sclerosis; Small deletions
CX091096; Amyotrophic lateral sclerosis ; Small indels CI092245; Amyotrophic lateral sclerosis; Small insertions CM091088; Amyotrophic lateral sclerosis ; Missense/nonsense CM091097; Amyotrophic lateral sclerosis; Missense/nonsense CM091087; Amyotrophic lateral sclerosis ; Missense/nonsense |
| GWASdb (count: 3) | rs741810; Acenocoumarol maintenance dosage; blood coagulation disease
rs1052352; Warfarin responsiveness (phenprocoumon); coronary artery disease|pulmonary embolism rs4889537; Type 2 diabetes; type 2 diabetes mellitus |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 22) (view all) | 131 QPQSGSYSQQPSYGG dbPAF
19 QSYGAYPTQPGQGYS dbPAF 221 GGRGRGGSGGGGGGG dbPAF 232 GGGGGGGYNRSSGGY dbPAF 257 GRGGMGGSDRGGFNK dbPAF 26 TQPGQGYSQQSSQPY dbPAF |
| Acetylation (count: 9) (view all) | 264 SDRGGFNKFGGPRDQ PLMD
312 FKQIGIIKTNKKTGQ PLMD 332 YTDRETGKLKGEATV PLMD 334 DRETGKLKGEATVSF PLMD 357 AIDWFDGKEFSGNPI PLMD 365 EFSGNPIKVSFATRR PLMD |
| Ubiquitination (count: 9) (view all) | 264 SDRGGFNKFGGPRDQ PLMD
315 IGIIKTNKKTGQPMI PLMD 316 GIIKTNKKTGQPMIN PLMD 334 DRETGKLKGEATVSF PLMD 348 FDDPPSAKAAIDWFD PLMD 357 AIDWFDGKEFSGNPI PLMD |
| Sumoylation (count: 1) | 334 DRETGKLKGEATVSF PLMD |
| Malonylation (count: 1) | 316 GIIKTNKKTGQPMIN PLMD |
| Network | Interaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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