| Tag | Content |
|---|---|
| UniProt Accession | DNM3A_MOUSE; O88508; |
| Entrez ID | 13435 |
| GenBank Protein ID | NM_001271753.1; NM_007872.4; NM_153743.4; XM_006514953.3; XM_006514956.3; |
| GenBank Nucleotide ID | NP_001258682.1; NP_031898.1; NP_714965.1; XP_006515016.1; XP_006515019.1; |
| Protein Name | DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (DNA methyltransferase MmuIIIA) (DNA MTase MmuIIIA) (M.MmuIIIA) |
| Gene Name | Dnmt3a |
| Organism | Mus musculus |
| NCBI Taxa ID | 10090 |
| Functional Description | Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. |
| Sequence (Fasta) | MPSSGPGDTS SSSLEREDDR KEGEEQEENR GKEERQEPSA TARKVGRPGR KRKHPPVESS 60 DTPKDPAVTT KSQPMAQDSG PSDLLPNGDL EKRSEPQPEE GSPAAGQKGG APAEGEGTET 120 PPEASRAVEN GCCVTKEGRG ASAGEGKEQK QTNIESMKME GSRGRLRGGL GWESSLRQRP 180 MPRLTFQAGD PYYISKRKRD EWLARWKREA EKKAKVIAVM NAVEENQASG ESQKVEEASP 240 PAVQQPTDPA SPTVATTPEP VGGDAGDKNA TKAADDEPEY EDGRGFGIGE LVWGKLRGFS 300 WWPGRIVSWW MTGRSRAAEG TRWVMWFGDG KFSVVCVEKL MPLSSFCSAF HQATYNKQPM 360 YRKAIYEVLQ VASSRAGKLF PACHDSDESD SGKAVEVQNK QMIEWALGGF QPSGPKGLEP 420 PEEEKNPYKE VYTDMWVEPE AAAYAPPPPA KKPRKSTTEK PKVKEIIDER TRERLVYEVR 480 QKCRNIEDIC ISCGSLNVTL EHPLFIGGMC QNCKNCFLEC AYQYDDDGYQ SYCTICCGGR 540 EVLMCGNNNC CRCFCVECVD LLVGPGAAQA AIKEDPWNCY MCGHKGTYGL LRRREDWPSR 600 LQMFFANNHD QEFDPPKVYP PVPAEKRKPI RVLSLFDGIA TGLLVLKDLG IQVDRYIASE 660 VCEDSITVGM VRHQGKIMYV GDVRSVTQKH IQEWGPFDLV IGGSPCNDLS IVNPARKGLY 720 EGTGRLFFEF YRLLHDARPK EGDDRPFFWL FENVVAMGVS DKRDISRFLE SNPVMIDAKE 780 VSAAHRARYF WGNLPGMNRP LASTVNDKLE LQECLEHGRI AKFSKVRTIT TRSNSIKQGK 840 DQHFPVFMNE KEDILWCTEM ERVFGFPVHY TDVSNMSRLA RQRLLGRSWS VPVIRHLFAP 900 LKEYFACV 909 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 18) (view all) | MESH:D000067877
; Autism Spectrum Disorder MESH:D001943 ; Breast Neoplasms MESH:C538445 ; Clear-cell metastatic renal cell carcinoma MESH:D019465 ; Craniofacial Abnormalities MESH:D003424 ; Crohn Disease MESH:D019066 ; Facies |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 12) (view all) | 102 EPQPEEGSPAAGQKG dbPAF
118 APAEGEGTETPPEAS dbPAF 120 AEGEGTETPPEASRA dbPAF 13 PGDTSSSSLEREDDR dbPAF 239 SQKVEEASPPAVQQP dbPAF 251 QQPTDPASPTVATTP dbPAF |
| Acetylation (count: 1) | 676 GMVRHQGKIMYVGDV PLMD |
| Ubiquitination (count: 1) | 196 GDPYYISKRKRDEWL PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |