Q16828

※ Protein Information

Tag	Content
UniProt Accession	DUS6_HUMAN; Q16828;
Entrez ID	1848
GenBank Protein ID	NM_001946.3; NM_022652.3;
GenBank Nucleotide ID	NP_001937.2; NP_073143.2;
Protein Name	Dual specificity protein phosphatase 6 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST1) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3)
Gene Name	DUSP6; MKP3; PYST1
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:9858808). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Functional Description Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:9858808). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity).
Sequence (Fasta)	MIDTLRPVPF ASEMAISKTV AWLNEQLELG NERLLLMDCR PQELYESSHI ESAINVAIPG 60 IMLRRLQKGN LPVRALFTRG EDRDRFTRRC GTDTVVLYDE SSSDWNENTG GESVLGLLLK 120 KLKDEGCRAF YLEGGFSKFQ AEFSLHCETN LDGSCSSSSP PLPVLGLGGL RISSDSSSDI 180 ESDLDRDPNS ATDSDGSPLS NSQPSFPVEI LPFLYLGCAK DSTNLDVLEE FGIKYILNVT 240 PNLPNLFENA GEFKYKQIPI SDHWSQNLSQ FFPEAISFID EARGKNCGVL VHCLAGISRS 300 VTVTVAYLMQ KLNLSMNDAY DIVKMKKSNI SPNFNFMGQL LDFERTLGLS SPCDNRVPAQ 360 QLYFTTPSNQ NVYQVDSLQS T 382 Fasta Sequence >Q16828\|DUSP6; MKP3; PYST1\|Homo sapiens (Human) MIDTLRPVPFASEMAISKTVAWLNEQLELGNERLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRGEDRDRFTRRCGTDTVVLYDESSSDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFSLHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQQLYFTTPSNQNVYQVDSLQST

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Methylation	Potentially fatal disease		D		3834198; 24260056
1	[Reference]: Low DUSP6 protein expression was significantly associated with pathological grade in ESCC by immunohistochemistry (P<0.05). Treatment with 5-aza-2'-deoxycytidine restored DUSP6 expression in the two ESCC cell lines, and the expression varied according to the drug concentration

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 8) (view all)	MESH:D002277 ; Carcinoma MESH:D005909 ; Glioblastoma OMIM:615269 ; HYPOGONADOTROPIC HYPOGONADISM 19 WITH OR WITHOUT ANOSMIA MESH:C562785 ; Idiopathic Hypogonadotropic Hypogonadism MESH:D008106 ; Liver Cirrhosis, Experimental MESH:D015674 ; Mammary Neoplasms, Animal MESH:D008325 ; Mammary Neoplasms, Experimental MESH:D017202 ; Myocardial Ischemia
DisGeNet (Curated) (count: 55) (view all)	C0003126; Anosmia C0003467; Anxiety C0005586; Bipolar Disorder C0010417; Cryptorchidism C0011570; Mental Depression C0011581; Depressive disorder C0017636; Glioblastoma C0018418; Gynecomastia C0023893; Liver Cirrhosis, Experimental C0024667; Animal Mammary Neoplasms C0024668; Mammary Neoplasms, Experimental C0029453; Osteopenia C0029456; Osteoporosis C0034012; Delayed Puberty C0036341; Schizophrenia C0151721; Testicular hypogonadism C0151744; Myocardial Ischemia C0162809; Kallmann Syndrome C0232939; Primary physiologic amenorrhea C0232940; Secondary physiologic amenorrhea C0241355; Small testicle C0242350; Erectile dysfunction C0266013; Congenital hypoplasia of breast C0266399; Infantile uterus C0266435; Congenital hypoplasia of penis C0271578; Female hypogonadism syndrome C0271623; Hypogonadotropic hypogonadism C0520927; Decreased fertility C0525045; Mood Disorders C0541764; Delayed bone age C0685840; Congenital hypoplasia of ovary C0747078; Generalized osteopenia C1563720; Kallmann Syndrome 2 (disorder) C1827524; Wide spaced nipples C1835452; Hypoplastic ovary C1846228; Absence of pubertal development C1858573; Sparse pubic hair C1858574; Sparse axillary hair C1860121; Decreased testosterone in males C1862863; Sparse body hair C2364082; Sense of smell impaired C2674432; Decreased bone mineral density Z score C3489396; Hypogonadism, Isolated Hypogonadotropic C3808981; HYPOGONADOTROPIC HYPOGONADISM 19 WITH OR WITHOUT ANOSMIA C4020884; Anxiety disease C4020899; Autosomal recessive predisposition C4021107; Non-obstructive azoospermia C4021551; Absence of secondary sex characteristics C4021776; Abnormality of the voice C4022003; Erectile abnormalities C4022675; Increased female libido C4025569; Eunuchoid habitus C4025644; Hypothalamic gonadotropin-releasing hormone deficiency C4025821; Anterior hypopituitarism C4025901; Abnormality of body height

Database

Annotation

CTD (Curated)
(count: 8)
(view all)

MESH:D002277 ; Carcinoma
MESH:D005909 ; Glioblastoma
OMIM:615269 ; HYPOGONADOTROPIC HYPOGONADISM 19 WITH OR WITHOUT ANOSMIA
MESH:C562785 ; Idiopathic Hypogonadotropic Hypogonadism
MESH:D008106 ; Liver Cirrhosis, Experimental
MESH:D015674 ; Mammary Neoplasms, Animal

DisGeNet (Curated)
(count: 55)
(view all)

C0003126; Anosmia
C0003467; Anxiety
C0005586; Bipolar Disorder
C0010417; Cryptorchidism
C0011570; Mental Depression
C0011581; Depressive disorder

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 11) (view all)	159 DGSCSSSSPPLPVLG dbPAF 174 LGGLRISSDSSSDIE dbPAF 178 RISSDSSSDIESDLD dbPAF 182 DSSSDIESDLDRDPN dbPAF 197 SATDSDGSPLSNSQP dbPAF 205 PLSNSQPSFPVEILP dbPAF 255 ENAGEFKYKQIPISD dbPAF 300 CLAGISRSVTVTVAY dbPAF 328 DIVKMKKSNISPNFN dbPAF 331 KMKKSNISPNFNFMG dbPAF 351 ERTLGLSSPCDNRVP dbPAF
Ubiquitination (count: 4)	254 FENAGEFKYKQIPIS PLMD 324 NDAYDIVKMKKSNIS PLMD 327 YDIVKMKKSNISPNF PLMD 68 IMLRRLQKGNLPVRA PLMD

※ Protein-Protein Interaction

Network

Interaction

Source

P27361	Q16828	HPRD; MINT
P28482	Q16828	HPRD; MINT
Q16828	Q8IYF3	HPRD; IntAct; MINT
Q16828	Q99750	HPRD; IntAct; MINT
Q16828	Q9UDV6	IntAct

PTMD Annotation Information

※ Protein Information

Functional Description

Fasta Sequence

※ PTM-Disease Association

※ Disease Cross-ref Annotation

※ PTM Sites

※ Protein-Protein Interaction