P16455

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession MGMT_HUMAN; P16455;
Entrez ID 4255
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O-methylguanine-DNA methyltransferase) (MGMT) (O-6-methylguanine-DNA-alkyltransferase)
Gene Name MGMT
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionInvolved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
Sequence
(Fasta)		MDKDCEMKRT TLDSPLGKLE LSGCEQGLHE IKLLGKGTSA ADAVEVPAPA AVLGGPEPLM 60
QCTAWLNAYF HQPEAIEEFP VPALHHPVFQ QESFTRQVLW KLLKVVKFGE VISYQQLAAL 120
AGNPKAARAV GGAMRGNPVP ILIPCHRVVC SSGAVGNYSG GLAVKEWLLA HEGHRLGKPG 180
LGGSSGLAGA WLKGAGATSG SPPAGRN 208

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1MethylationGlioma/Adult gliomasA24076583
[Reference]: the analysis of MGMT methylation status in two phase III trials suggests that this alteration may guide treatment decisions
2MethylationGlioblastomaN24267971
[Reference]: We retrospectively evaluated the incidence of PP in adult patients with sGBM treated with chemoradiation therapy (CRTx) using temozolomide (TMZ) and sought to assess if there was an association between PP and MGMT promoter methylation status, IDH mutations status, or 1p/19q codeletion
3MethylationGastric cancerU3905372; 24550949
[Reference]: We found the aberrant hypermethylation of cancer-related genes, such as P16, MGMT and HMLH1, could be predictive biomarkers for detection of gastric cancer

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 12)
(view all)		MESH:D001932 ; Brain Neoplasms
MESH:C535575 ; Carcinoma, squamous cell of head and neck
MESH:C562729 ; Esophageal Squamous Cell Carcinoma
MESH:D005909 ; Glioblastoma
MESH:D005910 ; Glioma
MESH:D007938 ; Leukemia
DisGeNet (Curated)
(count: 25)
(view all)		C0006118; Brain Neoplasms
C0016689; Freckles
C0017636; Glioblastoma
C0017638; Glioma
C0023418; leukemia
C0023893; Liver Cirrhosis, Experimental
HGMD
(count: 5)		CM024567; Enzyme activity, association with; Missense/nonsense
CM065311; Endometrial cancer risk, assoc. with; Missense/nonsense
CM004820; Lung cancer, risk, association with; Missense/nonsense
CM071862; Cervical carcinoma, incr. risk, association with; Missense/nonsense
CR075258; Promoter methylation in colorectal cancer, association ?; Regulatory
GWASdb
(count: 19)
(view all)		rs12259379; Urinary metabolites; kidney disease
rs4751095; Taste perception; sensory system disease
rs556253; Suicide attempts in bipolar disorder; bipolar disorder
rs579325; Suicide attempts in bipolar disorder; bipolar disorder
rs511361; Suicide attempts in bipolar disorder; bipolar disorder
rs551491; Cognition, early reading ability; reading disorder|cognitive disorder|language disorder|speech disorder

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 7)
(view all)		 10        KDCEMKRTTLDSPLG     dbPAF
11        DCEMKRTTLDSPLGK     dbPAF
14        MKRTTLDSPLGKLEL     dbPAF
158       SSGAVGNYSGGLAVK     dbPAF
198       WLKGAGATSGSPPAG     dbPAF
199       LKGAGATSGSPPAGR     dbPAF
Acetylation
(count: 2)		 101       FTRQVLWKLLKVVKF     PLMD
165       YSGGLAVKEWLLAHE     PLMD
Ubiquitination
(count: 7)
(view all)		 101       FTRQVLWKLLKVVKF     PLMD
104       QVLWKLLKVVKFGEV     PLMD
125       AALAGNPKAARAVGG     PLMD
165       YSGGLAVKEWLLAHE     PLMD
178       HEGHRLGKPGLGGSS     PLMD
32        EQGLHEIKLLGKGTS     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource