Tag | Content |
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UniProt Accession | ANM5_HUMAN; O14744; |
Entrez ID | 10419 |
GenBank Protein ID | NM_001039619.2; NM_001282953.1; NM_001282955.1; NM_001282956.1; NM_006109.4; |
GenBank Nucleotide ID | NP_001034708.1; NP_001269882.1; NP_001269884.1; NP_001269885.1; NP_006100.2; |
Protein Name | Protein arginine N-methyltransferase 5 (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-meth |
Gene Name | PRMT5; HRMT1L5; IBP72; JBP1; SKB1 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21258366, PubMed:21917714, PubMed:22269951). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being requir(view all) |
Sequence (Fasta) | MAAMAVGGAG GSRVSSGRDL NCVPEIADTL GAVAKQGFDF LCMPVFHPRF KREFIQEPAK 60 NRPGPQTRSD LLLSGRDWNT LIVGKLSPWI RPDSKVEKIR RNSEAAMLQE LNFGAYLGLP 120 AFLLPLNQED NTNLARVLTN HIHTGHHSSM FWMRVPLVAP EDLRDDIIEN APTTHTEEYS 180 GEEKTWMWWH NFRTLCDYSK RIAVALEIGA DLPSNHVIDR WLGEPIKAAI LPTSIFLTNK 240 KGFPVLSKMH QRLIFRLLKL EVQFIITGTN HHSEKEFCSY LQYLEYLSQN RPPPNAYELF 300 AKGYEDYLQS PLQPLMDNLE SQTYEVFEKD PIKYSQYQQA IYKCLLDRVP EEEKDTNVQV 360 LMVLGAGRGP LVNASLRAAK QADRRIKLYA VEKNPNAVVT LENWQFEEWG SQVTVVSSDM 420 REWVAPEKAD IIVSELLGSF ADNELSPECL DGAQHFLKDD GVSIPGEYTS FLAPISSSKL 480 YNEVRACREK DRDPEAQFEM PYVVRLHNFH QLSAPQPCFT FSHPNRDPMI DNNRYCTLEF 540 PVEVNTVLHG FAGYFETVLY QDITLSIRPE THSPGMFSWF PILFPIKQPI TVREGQTICV 600 RFWRCSNSKK VWYEWAVTAP VCSAIHNPTG RSYTIGL 638 |
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PTM | Modification Sites |
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Phosphorylation (count: 12) (view all) | 12 AVGGAGGSRVSSGRD dbPAF
280 SEKEFCSYLQYLEYL dbPAF 283 EFCSYLQYLEYLSQN dbPAF 286 SYLQYLEYLSQNRPP dbPAF 297 NRPPPNAYELFAKGY dbPAF 304 YELFAKGYEDYLQSP dbPAF |
Acetylation (count: 3) | 200 RTLCDYSKRIAVALE PLMD
240 TSIFLTNKKGFPVLS PLMD 490 EVRACREKDRDPEAQ PLMD |
Ubiquitination (count: 13) (view all) | 200 RTLCDYSKRIAVALE PLMD
227 RWLGEPIKAAILPTS PLMD 240 TSIFLTNKKGFPVLS PLMD 241 SIFLTNKKGFPVLSK PLMD 329 QTYEVFEKDPIKYSQ PLMD 333 VFEKDPIKYSQYQQA PLMD |
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