| Tag | Content |
|---|---|
| UniProt Accession | 2A5G_HUMAN; Q13362; |
| Entrez ID | 5527 |
| GenBank Protein ID | NM_001161725.1; NM_001161726.1; NM_002719.3; NM_178586.2; NM_178587.2; XM_005267827.1; XM_011536920.1; |
| GenBank Nucleotide ID | NP_001155197.1; NP_001155198.1; NP_002710.2; NP_848701.1; NP_848702.1; XP_005267884.1; XP_011535222.1; |
| Protein Name | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A B subunit isoform B'-gamma) (PP2A B subunit isoform B56-gamma) (PP2A B subunit isoform PR61-gamma) (PP2A B subunit isoform R5-gamma) (Renal carcinoma antigen NY-REN-29) |
| Gene Name | PPP2R5C; KIAA0044 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. |
| Sequence (Fasta) | MLTCNKAGSR MVVDAANSNG PFQPVVLLHI RDVPPADQEK LFIQKLRQCC VLFDFVSDPL 60 SDLKWKEVKR AALSEMVEYI THNRNVITEP IYPEVVHMFA VNMFRTLPPS SNPTGAEFDP 120 EEDEPTLEAA WPHLQLVYEF FLRFLESPDF QPNIAKKYID QKFVLQLLEL FDSEDPRERD 180 FLKTTLHRIY GKFLGLRAYI RKQINNIFYR FIYETEHHNG IAELLEILGS IINGFALPLK 240 EEHKIFLLKV LLPLHKVKSL SVYHPQLAYC VVQFLEKDST LTEPVVMALL KYWPKTHSPK 300 EVMFLNELEE ILDVIEPSEF VKIMEPLFRQ LAKCVSSPHF QVAERALYYW NNEYIMSLIS 360 DNAAKILPIM FPSLYRNSKT HWNKTIHGLI YNALKLFMEM NQKLFDDCTQ QFKAEKLKEK 420 LKMKEREEAW VKIENLAKAN PQYTVYSQAS TMSIPVAMET DGPLFEDVQM LRKTVKDEAH 480 QAQKDPKKDR PLARRKSELP QDPHTKKALE AHCRADELAS QDGR 525 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 3) | MESH:D043171
; Chromosomal Instability MESH:D015451 ; Leukemia, Lymphocytic, Chronic, B-Cell MESH:D048629 ; Micronuclei, Chromosome-Defective |
| GWASdb (count: 15) (view all) | rs11625483; Coronary heart disease; coronary artery disease
rs1746598; Salmonella-induced pyroptosis; Null rs8016207; Urinary metabolites; kidney disease rs1678002; Salmonella-induced pyroptosis; Null rs8015021; Response to cytadine analogues (cytosine arabinoside); cancer rs1746595; Multiple complex diseases; Null |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 13) (view all) | 209 KQINNIFYRFIYETE dbPAF
298 KYWPKTHSPKEVMFL dbPAF 336 RQLAKCVSSPHFQVA dbPAF 348 QVAERALYYWNNEYI dbPAF 349 VAERALYYWNNEYIM dbPAF 354 LYYWNNEYIMSLISD dbPAF |
| Acetylation (count: 3) | 156 DFQPNIAKKYIDQKF PLMD
413 DDCTQQFKAEKLKEK PLMD 45 QEKLFIQKLRQCCVL PLMD |
| Ubiquitination (count: 11) (view all) | 156 DFQPNIAKKYIDQKF PLMD
157 FQPNIAKKYIDQKFV PLMD 183 PRERDFLKTTLHRIY PLMD 258 LLPLHKVKSLSVYHP PLMD 291 PVVMALLKYWPKTHS PLMD 333 PLFRQLAKCVSSPHF PLMD |
| Malonylation (count: 2) | 156 DFQPNIAKKYIDQKF PLMD
413 DDCTQQFKAEKLKEK PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |