| Tag | Content |
|---|---|
| UniProt Accession | SFRP1_HUMAN; Q8N474; |
| Entrez ID | 6422 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Secreted frizzled-related protein 1 (FRP-1) (sFRP-1) (Secreted apoptosis-related protein 2) (SARP-2) |
| Gene Name | SFRP1; FRP; FRP1; SARP2 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription. |
| Sequence (Fasta) | MGIGRSEGGR RGAALGVLLA LGAALLAVGS ASEYDYVSFQ SDIGPYQSGR FYTKPPQCVD 60 IPADLRLCHN VGYKKMVLPN LLEHETMAEV KQQASSWVPL LNKNCHAGTQ VFLCSLFAPV 120 CLDRPIYPCR WLCEAVRDSC EPVMQFFGFY WPEMLKCDKF PEGDVCIAMT PPNATEASKP 180 QGTTVCPPCD NELKSEAIIE HLCASEFALR MKIKEVKKEN GDKKIVPKKK KPLKLGPIKK 240 KDLKKLVLYL KNGADCPCHQ LDNLSHHFLI MGRKVKSQYL LTAIHKWDKK NKEFKNFMKK 300 MKNHECPTFQ SVFK 315 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 4) | MESH:D001943
; Breast Neoplasms MESH:D015179 ; Colorectal Neoplasms MESH:D015212 ; Inflammatory Bowel Diseases MESH:D007889 ; Leiomyoma |
| GWASdb (count: 2) | rs11774662; Narcolepsy; narcolepsy
rs7834090; Multiple complex diseases; Null |
| PTM | Modification Sites |
|---|---|
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |