Q99626

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession CDX2_HUMAN; Q99626;
Entrez ID 1045
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Homeobox protein CDX-2 (CDX-3) (Caudal-type homeobox protein 2)
Gene Name CDX2; CDX3
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionInvolved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.
Sequence
(Fasta)		MYVSYLLDKD VSMYPSSVRH SGGLNLAPQN FVSPPQYPDY GGYHVAAAAA AAANLDSAQS 60
PGPSWPAAYG APLREDWNGY APGGAAAAAN AVAHGLNGGS PAAAMGYSSP ADYHPHHHPH 120
HHPHHPAAAP SCASGLLQTL NPGPPGPAAT AAAEQLSPGG QRRNLCEWMR KPAQQSLGSQ 180
VKTRTKDKYR VVYTDHQRLE LEKEFHYSRY ITIRRKAELA ATLGLSERQV KIWFQNRRAK 240
ERKINKKKLQ QQQQQQPPQP PPPPPQPPQP QPGPLRSVPE PLSPVSSLQA SVPGSVPGVL 300
GPTGGVLNPT VTQ 314

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1MethylationColon cancer/carcinomaP24166180
[Reference]: CDX2 methylation correlated with BRAF(V600E) (P = 0.0184) and with Cdx2 protein loss (P = 0.0028). These results seem to indicate that Cdx2 may play a role in the serrated pathway to colorectal cancer as underlined by strong relationships with BRAF(V600E), CIMP-high and MMR-deficiency

※ Disease Cross-ref Annotation

DatabaseAnnotation
Cancer Gene Census
AML

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 13)
(view all)		 14        LDKDVSMYPSSVRHS     dbPAF
2         ******MYVSYLLDK     dbPAF
226       LAATLGLSERQVKIW     dbPAF
277       PQPGPLRSVPEPLSP     dbPAF
283       RSVPEPLSPVSSLQA     dbPAF
287       EPLSPVSSLQASVPG     dbPAF

※ Protein-Protein Interaction

NetworkInteraction
ABSource