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Browse result for Glycosylation
※ introduction Glycosylation (see also chemical glycosylation) is the reaction in which a carbohydrate, i.e. a glycosyl donor, is attached to a hydroxyl or other functional group of another molecule (a glycosyl acceptor). In biology glycosylation mainly refers in particular to the enzymatic process that attaches glycans to proteins, lipids, or other organic molecules. This enzymatic process produces one of the fundamental biopolymers found in cells (along with DNA, RNA, and proteins). Glycosylation is a form of co-translational and post-translational modification. Glycans serve a variety of structural and functional roles in membrane and secreted proteins.[1] The majority of proteins synthesized in the rough ER undergo glycosylation. It is an enzyme-directed site-specific process, as opposed to the non-enzymatic chemical reaction of glycation. Glycosylation is also present in the cytoplasm and nucleus as the O-GlcNAc modification. Five classes of glycans are produced: (i)N-linked glycans attached to a nitrogen of asparagine or arginine side-chains. N-linked glycosylation requires participation of a special lipid called dolichol phosphate.(ii)O-linked glycans attached to the hydroxyl oxygen of serine, threonine, tyrosine, hydroxylysine, or hydroxyproline side-chains, or to oxygens on lipids such as ceramide phospho-glycans linked through the phosphate of a phospho-serine.(iii)C-linked glycans, a rare form of glycosylation where a sugar is added to a carbon on a tryptophan side-chai glypiation, which is the addition of a GPI anchor that links proteins to lipids through glycan linkages.
Reference
Wiki: Glycosylation
Reference
Wiki: Glycosylation
UniProt AC | Entrez ID | Gene Name | Protein Name | Organism |
---|---|---|---|---|
O43505 | 11041 | B4GAT1 | Beta-1,4-glucuronyltransferase 1 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminy | Homo sapiens |
O43556 | 8910 | SGCE | Epsilon-sarcoglycan | Homo sapiens |
P00451 | 2157 | F8 | Coagulation factor VIII [Cleaved into: Factor VIIIa heavy chain, 200 kDa isoform; Factor VIIIa heavy chain, 92 kDa isoform; Factor VIII B chain; Factor VIIIa light chain] | Homo sapiens |
P01008 | 462 | SERPINC1 | Antithrombin-III | Homo sapiens |
P02671 | 2243 | FGA | Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] | Homo sapiens |
P02763 | 5004 | ORM1 | Alpha-1-acid glycoprotein 1 | Homo sapiens |
P04001 | 2652 | OPN1MW | Medium-wave-sensitive opsin 1 | Homo sapiens |
P05067 | 351 | APP | Amyloid-beta A4 protein [Cleaved into: N-APP; Soluble APP-a | Homo sapiens |
P05107 | 3689 | ITGB2 | Integrin beta-2 | Homo sapiens |
P05155 | 710 | SERPING1 | Plasma protease C1 inhibitor | Homo sapiens |
P07858 | 1508 | CTSB | Cathepsin B [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] | Homo sapiens |
P08047 | 6667 | SP1 | Transcription factor Sp1 | Homo sapiens |
P08069 | 3480 | IGF1R | Insulin-like growth factor 1 receptor [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] | Homo sapiens |
P08236 | 2990 | GUSB | Beta-glucuronidase | Homo sapiens |
P08581 | 4233 | MET | Hepatocyte growth factor receptor | Homo sapiens |
P10619 | 5476 | CTSA | Lysosomal protective protein [Cleaved into: Lysosomal protective protein 32 kDa chain; Lysosomal prot | Homo sapiens |
P10636 | 4137 | MAPT | Microtubule-associated protein tau | Homo sapiens |
P14222 | 5551 | PRF1 | Perforin-1 | Homo sapiens |
P15941 | 4582 | MUC1 | Mucin-1 (T | Homo sapiens |
P16422 | 4072 | EPCAM | Epithelial cell adhesion molecule (Ma | Homo sapiens |
P27695 | 328 | APEX1 | DNA- lyase [Cleaved into: DNA- lyase, mitochondria | Homo sapiens |
P29965 | 959 | CD40LG | CD40 ligand [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form] | Homo sapiens |
P31785 | 3561 | IL2RG | Cytokine receptor common subunit gamma | Homo sapiens |
P49768 | 5663 | PSEN1 | Presenilin-1 [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 ] | Homo sapiens |
Q13454 | 7991 | TUSC3 | Tumor suppressor candidate 3 | Homo sapiens |
Q14118 | 1605 | DAG1 | Dystroglycan [Cleaved into: Alpha-dystroglycan ; Beta-dystroglycan ] | Homo sapiens |
Q62165 | 13138 | Dag1 | Dystroglycan [Cleaved into: Alpha-dystroglycan ; Beta-dystroglycan ] | Mus musculus |
Q6P179 | 64167 | ERAP2 | Endoplasmic reticulum aminopeptidase 2 | Homo sapiens |
Q8TCJ2 | 201595 | STT3B | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B | Homo sapiens |
Q8WXI7 | 94025 | MUC16 | Mucin-16 | Homo sapiens |
Q99795 | 10223 | GPA33 | Cell surface A33 antigen | Homo sapiens |
Q9UHD1 | 26973 | CHORDC1 | Cysteine and histidine-rich domain-containing protein 1 | Homo sapiens |
Q9UQ07 | 5891 | MOK | MAPK/MAK/MRK overlapping kinase | Homo sapiens |