Tag | Content |
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UniProt Accession | PDPK1_MOUSE; Q9Z2A0; |
Entrez ID | 18607 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | 3-phosphoinositide-dependent protein kinase 1 (mPDK1) (EC 2.7.11.1) |
Gene Name | Pdpk1; Pdk1 |
Organism | Mus musculus |
NCBI Taxa ID | 10090 |
Functional Description | Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central role in (view all) |
Sequence (Fasta) | MARTTSQLYD AVPIQSSVVL CSCPSPSMVR SQTEPGSSPG IPSGVSRQGS TMDGTTAEAR 60 PSTNPLQQHP AQLPPQPRKK RPEDFKFGKI LGEGSFSTVV LARELATSRE YAIKILEKRH 120 IIKENKVPYV TRERDVMSRL DHPFFVKLYF TFQDDEKLYF GLSYAKNGEL LKYIRKIGSF 180 DETCTRFYTA EIVSALEYLH GKGIIHRDLK PENILLNEDM HIQITDFGTA KVLSPESKQA 240 RANSFVGTAQ YVSPELLTEK SACKSSDLWA LGCIIYQLVA GLPPFRAGNE YLIFQKIIKL 300 EYHFPEKFFP KARDLVEKLL VLDATKRLGC EEMEGYGPLK AHPFFETITW ENLHQQTPPK 360 LTAYLPAMSE DDEDCYGNYD NLLSQFGFMQ VSSSSSSHSL STVETSLPQR SGSNIEQYIH 420 DLDTNSFELD LQFSEDEKRL LLEKQAGGNP WHQFVENNLI LKMGPVDKRK GLFARRRQLL 480 LTEGPHLYYV DPVNKVLKGE IPWSQELRPE AKNFKTFFVH TPNRTYYLMD PSGNAHKWCR 540 KIQEVWRQQY QSNPDAAVQ |
|
Database | Annotation |
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CTD (Curated) (count: 3) | MESH:D001943
; Breast Neoplasms MESH:D006333 ; Heart Failure MESH:D016403 ; Lymphoma, Large B-Cell, Diffuse |
PTM | Modification Sites |
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Phosphorylation (count: 17) (view all) | 163 EKLYFGLSYAKNGEL dbPAF
234 FGTAKVLSPESKQAR dbPAF 244 SKQARANSFVGTAQY dbPAF 248 RANSFVGTAQYVSPE dbPAF 25 VVLCSCPSPSMVRSQ dbPAF 251 SFVGTAQYVSPELLT dbPAF |
Network | Interaction | ||
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A | B | Source | |