| Tag | Content |
|---|---|
| UniProt Accession | ESYT1_RAT; Q9Z1X1; |
| Entrez ID | 29579 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein) (vp115) |
| Gene Name | Esyt1; Fam62a; Mbc2 |
| Organism | Rattus norvegicus |
| NCBI Taxa ID | 10116 |
| Functional Description | Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (By similarity). |
| Sequence (Fasta) | MERSPEEGAG PEPSGQSPAT DSTRERDGGS GVPPAGPGAA SEALAVLTSF GRRLLVLVPV 60 YLAGAAGLSV GFVLFGLALY LGWRRVRDGK ERSLRAARQL LDDEERITAE TLYMSHRELP 120 AWVSFPDVEK AEWLNKIVVQ VWPFLGQYME KLLAETVAPA VRGANPHLQT FTFTRVELGE 180 KPVRIIGVKV HPSQRKDQIL LDLNVSYVGD LQIDVEVKKY FCKAGVKGMQ LHGVLRVILE 240 PLIGDLPIVG AVSMFFIKRP TLDINWTGMT NLLDIPGLSS LSDTMIMDSI AAFLVLPNRL 300 LVPLVPDLQD VAQLRSPLPR GIIRIHLLAA RGLSSKDKYV KGLIEGKSDP YALVRVGTQT 360 FCSRVIDEEL NPHWGETYEV IVHEVPGQEI EVEVFDKDPD KDDFLGRMKL DVGKVLQAGV 420 LDNWYPLQGG QGQVHLRLEW LSLLPDAEKL DQVLQWNRGI TSRPEPPSAA ILVVYLDRAQ 480 DLPLKKGNKE PNPMVQLSVQ DVTQESKATY STNCPVWEEA FRFFLQDPRS QELDVQVKDD 540 SRALTLGALT LPLARLLTAS ELTLDQWFQL SSSGPNSRLY MKLVMRILYL DSSEMRLPTE 600 PGAQDWDSES PETGSSVDAP PRPYHTTPNS HFGTENVLRI HVLEAQDLIA KDRFLGGLVK 660 GKSDPYVKLK VAGRSLRTHV VREDLNPRWN EVFEVIVTSI PGQELDIEVF DKDLDKDDFL 720 GRYKVGLTTV LNSGFLDEWL TLEDVPSGRL HLRLERLSPR PTAAELEEVL QVNSLIQTQK 780 SSELAAALLS VYLERSEDLP LRKGTKPPSP YAILTVGETS HKTKTVSQTS APIWEESASF 840 LIRKPHAESL ELQVRGEGTG TLGSISLPLS ELLQEEQLCL DRWFALSGQG QVLMRVQLGI 900 LVSQHSGVEA HSHSSSSLNE EPEVLGDPTH TASPVLEVRH RLTHGDSPSE ALIGPLGQVK 960 LTVWYHSDEQ KLISIIHSCR ALRQNGRDLP DPYVSVLLLP DKNRGTKRKT SQKKRTLNPE 1020 FNERFEWDLP LDGTLRRKLD VSVKSNSSFM SRERELLGKV QLDLAEIDLS QGAAQWYDLI 1080 DDRDKGGS 1089 |
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| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 3) | 666 VKGKSDPYVKLKVAG dbPAF
811 GTKPPSPYAILTVGE dbPAF 993 GRDLPDPYVSVLLLP dbPAF |
| Acetylation (count: 3) | 409 DDFLGRMKLDVGKVL PLMD
660 RFLGGLVKGKSDPYV PLMD 806 LPLRKGTKPPSPYAI PLMD |
| Ubiquitination (count: 1) | 341 SSKDKYVKGLIEGKS PLMD |