Q9Z1S0

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession BUB1B_MOUSE; Q9Z1S0;
Entrez ID 12236
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (BubR1) (Mitotic checkpoint kinase MAD3L)
Gene Name Bub1b; Mad3l
Organism Mus musculus
NCBI Taxa ID 10090
Functional DescriptionEssential component of the mitotic checkpoint. Required for normal mitosis progression and tumor suppression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. Essential for tumor suppression. May play a role in regulating aging and fertility (By similarity).
Sequence
(Fasta)		MAEASEAMCL EGAEWELSKE NIQPLRHGRV MSTLQGALAK QESAGHTALQ QQKRAFESEI 60
RFYSGDDPLD VWDRYINWTE QNYPQGGKES NMSALVERAI EALQGETRYY NDPRFLSLWI 120
KLGHLCNEPL DMYSYLQSQG IGVSLAQFYI SWAEEYEARE NFKKADIIFQ EGIERKAEPL 180
DRLQSQHRQF QSRVSRQAFL ALGNEEEEAL EPSEPQRSSL AELKSRGKKM ARAPISRVGG 240
ALKAPGQSRG FLNAVPQPVH GNRRITVFDE NADTASRTEL SKPVAQPWMA PPVPRAKENE 300
LQPGPWSTDR PAGRRPHDNP ASVTSIPSVL PSFTPYVEES AQQTVMTPCK IEPSINHVLS 360
TRKPGREEGD PLQRVQSHQQ GCEEKKEKMM YCKEKIYAGV GEFSFEEIRA EVFRKKLKER 420
REAELLTSAK KREEMQKQIE EMERRLKAMQ AVQQEGAGGQ QEEKMPTEDP ARLQIASGPQ 480
EMSGVPLSCS ICPLSSNPRE ISPAENILQE QPDSKGSSMP FSIFDESLSD KKDKSPATGG 540
PQVLNAQRRP LSVLKTTEVG TTNEDVSPDI CDELTELEPL SEDAIITGFR NVTLCPNPED 600
TCDFARAARL ASTPFHEILS SKGIAADPEG LLQEEDLDGK AAEAHHTVHH QALIIKKLSP 660
IIEESREATH SSGFSRSSSS APSTSSIKGF QLLEKLELTN DGAEDAIQSP WCSQYRLQLL 720
KSLLELSAFA EFSVEDRPMP VLEIGKEIEL GPEDYVIKQE HLTCDDYRLF WVAPRSSAEL 780
TMIKASSQPI PWDFYINLKL KERLNEDYDQ LCSCCQYQDG HVVWYQYINC STLQNLLQHS 840
EFVTHEIIVL IIYNLLTIVE KLHRAEIVHG DLSPRSLILR NRIHDPYDYV NKDDHAVRIM 900
DFSYSVDLRV QLDAFAYSGF RTAQILEGQK ILANCSSPYH VDLLGIADLA HLLLFKEHLH 960
VFWDGLLWKL SQSTSELKDS ELWNKFFVRI LNASDKSTVS VLGELAAEMG GAFDATFHSH 1020
LNRALWKLGK TISPEALLTQ QDKQPGGSQS PA 1053

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1AcetylationLeukemiaNK24323878276
[Reference]: BubR1 acetylation is essential in mitosis. Mice heterozygous for the acetylation-deficient BubR1 allele (K243R/+) spontaneously developed tumors with massive chromosome missegregations.?

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 8)
(view all)		MESH:D015179 ; Colorectal Neoplasms
MESH:C562729 ; Esophageal Squamous Cell Carcinoma
MESH:D006130 ; Growth Disorders
MESH:D008831 ; Microcephaly
MESH:C536987 ; Mosaic variegated aneuploidy syndrome
MESH:D009373 ; Neoplasms, Germ Cell and Embryonal

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 35)
(view all)		 1033      WKLGKTISPEALLTQ     dbPAF
1048      QDKQPGGSQSPA***     dbPAF
1050      KQPGGSQSPA*****     dbPAF
225       SSLAELKSRGKKMAR     dbPAF
266       VHGNRRITVFDENAD     dbPAF
307       ELQPGPWSTDRPAGR     dbPAF