| Tag | Content |
|---|---|
| UniProt Accession | MORC2_HUMAN; Q9Y6X9; |
| Entrez ID | 22880 |
| GenBank Protein ID | NM_001303256.2; NM_001303257.2; NM_014941.3; XM_017028668.1; |
| GenBank Nucleotide ID | NP_001290185.1; NP_001290186.1; NP_055756.1; XP_016884157.1; |
| Protein Name | MORC family CW-type zinc finger protein 2 (Zinc finger CW-type coiled-coil domain protein 1) |
| Gene Name | MORC2; KIAA0852; ZCWCC1 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). May act as a transcriptional repressor (PubMed:20225202). Down-regulates CA9 expression (PubMed:20110259). |
| Sequence (Fasta) | MAFTNYSSLN RAQLTFEYLH TNSTTHEFLF GALAELVDNA RDADATRIDI YAERREDLRG 60 GFMLCFLDDG AGMDPSDAAS VIQFGKSAKR TPESTQIGQY GNGLKSGSMR IGKDFILFTK 120 KEDTMTCLFL SRTFHEEEGI DEVIVPLPTW NARTREPVTD NVEKFAIETE LIYKYSPFRT 180 EEEVMTQFMK IPGDSGTLVI IFNLKLMDNG EPELDIISNP RDIQMAETSP EGTKPERRSF 240 RAYAAVLYID PRMRIFIHGH KVQTKRLSCC LYKPRMYKYT SSRFKTRAEQ EVKKAEHVAR 300 IAEEKAREAE SKARTLEVRL GGDLTRDSRV MLRQVQNRAI TLRREADVKK RIKEAKQRAL 360 KEPKELNFVF GVNIEHRDLD GMFIYNCSRL IKMYEKVGPQ LEGGMACGGV VGVVDVPYLV 420 LEPTHNKQDF ADAKEYRHLL RAMGEHLAQY WKDIAIAQRG IIKFWDEFGY LSANWNQPPS 480 SELRYKRRRA MEIPTTIQCD LCLKWRTLPF QLSSVEKDYP DTWVCSMNPD PEQDRCEASE 540 QKQKVPLGTF RKDMKTQEEK QKQLTEKIRQ QQEKLEALQK TTPIRSQADL KKLPLEVTTR 600 PSTEEPVRRP QRPRSPPLPA VIRNAPSRPP SLPTPRPASQ PRKAPVISST PKLPALAARE 660 EASTSRLLQP PEAPRKPANT LVKTASRPAP LVQQLSPSLL PNSKSPREVP SPKVIKTPVV 720 KKTESPIKLS PATPSRKRSV AVSDEEEVEE EAERRKERCK RGRFVVKEEK KDSNELSDSA 780 GEEDSADLKR AQKDKGLHVE VRVNREWYTG RVTAVEVGKH VVRWKVKFDY VPTDTTPRDR 840 WVEKGSEDVR LMKPPSPEHQ SLDTQQEGGE EEVGPVAQQA IAVAEPSTSE CLRIEPDTTA 900 LSTNHETIDL LVQILRNCLR YFLPPSFPIS KKQLSAMNSD ELISFPLKEY FKQYEVGLQN 960 LCNSYQSRAD SRAKASEESL RTSERKLRET EEKLQKLRTN IVALLQKVQE DIDINTDDEL 1020 DAYIEDLITK GD 1033 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 2) | OMIM:616688
; CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2Z MESH:D002607 ; Charcot-Marie-Tooth Disease |
| DisGeNet (Curated) (count: 8) (view all) | C0015644; Muscular fasciculation
C0026821; Muscle Cramp C0026827; Muscle hypotonia C0311394; Difficulty walking C0684219; Myokymia C0728829; Congenital pes cavus |
| GWASdb (count: 2) | rs2074578; Multiple complex diseases; Null
rs1003480; Multiple complex diseases; Null |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 41) (view all) | 1016 QEDIDINTDDELDAY dbPAF
175 ETELIYKYSPFRTEE dbPAF 513 RTLPFQLSSVEKDYP dbPAF 582 LEALQKTTPIRSQAD dbPAF 602 LEVTTRPSTEEPVRR dbPAF 603 EVTTRPSTEEPVRRP dbPAF |
| Acetylation (count: 3) | 273 RLSCCLYKPRMYKYT PLMD
767 KRGRFVVKEEKKDSN PLMD 993 KLRETEEKLQKLRTN PLMD |
| Ubiquitination (count: 10) (view all) | 234 ETSPEGTKPERRSFR PLMD
293 TRAEQEVKKAEHVAR PLMD 427 VLEPTHNKQDFADAK PLMD 517 FQLSSVEKDYPDTWV PLMD 580 EKLEALQKTTPIRSQ PLMD 652 PVISSTPKLPALAAR PLMD |
| Sumoylation (count: 2) | 293 TRAEQEVKKAEHVAR PLMD
767 KRGRFVVKEEKKDSN PLMD |