| Tag | Content |
|---|---|
| UniProt Accession | RIPK3_HUMAN; Q9Y572; |
| Entrez ID | 11035 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) |
| Gene Name | RIPK3; RIP3 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. |
| Sequence (Fasta) | MSCVKLWPSG APAPLVSIEE LENQELVGKG GFGTVFRAQH RKWGYDVAVK IVNSKAISRE 60 VKAMASLDNE FVLRLEGVIE KVNWDQDPKP ALVTKFMENG SLSGLLQSQC PRPWPLLCRL 120 LKEVVLGMFY LHDQNPVLLH RDLKPSNVLL DPELHVKLAD FGLSTFQGGS QSGTGSGEPG 180 GTLGYLAPEL FVNVNRKAST ASDVYSFGIL MWAVLAGREV ELPTEPSLVY EAVCNRQNRP 240 SLAELPQAGP ETPGLEGLKE LMQLCWSSEP KDRPSFQECL PKTDEVFQMV ENNMNAAVST 300 VKDFLSQLRS SNRRFSIPES GQGGTEMDGF RRTIENQHSR NDVMVSEWLN KLNLEEPPSS 360 VPKKCPSLTK RSRAQEEQVP QAWTAGTSSD SMAQPPQTPE TSTFRNQMPS PTSTGTPSPG 420 PRGNQGAERQ GMNWSCRTPE PNPVTGRPLV NIYNCSGVQV GDNNYLTMQQ TTALPTWGLA 480 PSGKGRGLQH PPPVGSQEGP KDPEAWSRPQ GWYNHSGK 519 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 2) | MESH:D002114
; Calcinosis MESH:D006349 ; Heart Valve Diseases |
| DisGeNet (Curated) (count: 2) | C0006663; Calcinosis
C0018824; Heart valve disease |
| GWASdb (count: 2) | rs724165; Volumetric brain MRI; cognitive disorder
rs1950501; Multiple complex diseases; Null |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 7) (view all) | 199 VNVNRKASTASDVYS dbPAF
227 VELPTEPSLVYEAVC dbPAF 299 NNMNAAVSTVKDFLS dbPAF 300 NMNAAVSTVKDFLSQ dbPAF 316 RSSNRRFSIPESGQG dbPAF 320 RRFSIPESGQGGTEM dbPAF |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |