Q9Y4L5

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession RN115_HUMAN; Q9Y4L5;
Entrez ID 27246
GenBank Protein ID
GenBank Nucleotide ID
Protein Name E3 ubiquitin-protein ligase RNF115 (EC 2.3.2.27) (RING finger protein 115) (RING-type E3 ubiquitin transferase RNF115) (Rabring 7) (Zinc finger protein 364)
Gene Name RNF115; ZNF364
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionE3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4.
Sequence
(Fasta)		MAEASAAGAD SGAAVAAHRF FCHFCKGEVS PKLPEYICPR CESGFIEEVT DDSSFLGGGG 60
SRIDNTTTTH FAELWGHLDH TMFFQDFRPF LSSSPLDQDN RANERGHQTH TDFWGARPPR 120
LPLGRRYRSR GSSRPDRSPA IEGILQHIFA GFFANSAIPG SPHPFSWSGM LHSNPGDYAW 180
GQTGLDAIVT QLLGQLENTG PPPADKEKIT SLPTVTVTQE QVDMGLECPV CKEDYTVEEE 240
VRQLPCNHFF HSSCIVPWLE LHDTCPVCRK SLNGEDSTRQ SQSTEASASN RFSNDSQLHD 300
RWTF 305

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1UbiquitinationBreast cancer/tumor/carcinomaMCF-7 cell linePK26/3218819927
[Reference]: Autoubiquitination of BCA2 RING E3 ligase regulates its own stability and affects cell migration

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 1)		MESH:D001943 ; Breast Neoplasms
DisGeNet (Curated)
(count: 1)		C1458155; Mammary Neoplasms
GWASdb
(count: 31)
(view all)		rs61816194; Epilepsy (remission after treatment); epilepsy syndrome
rs12732381; Epilepsy (remission after treatment); epilepsy syndrome
rs17354594; Epilepsy (remission after treatment); epilepsy syndrome
rs12402867; Urate levels; gout
rs12402867; Epilepsy (remission after treatment); epilepsy syndrome
rs12724816; Urate levels; gout

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 5)		 281       GEDSTRQSQSTEASA     dbPAF
296       SNRFSNDSQLHDRWT     dbPAF
303       SQLHDRWTF******     dbPAF
53        IEEVTDDSSFLGGGG     dbPAF
61        SFLGGGGSRIDNTTT     dbPAF
Ubiquitination
(count: 2)		 26        RFFCHFCKGEVSPKL     PLMD
32        CKGEVSPKLPEYICP     PLMD
Methylation
(count: 1)		 26        RFFCHFCKGEVSPKL     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource