| Tag | Content |
|---|---|
| UniProt Accession | TRAF6_HUMAN; Q9Y4K3; |
| Entrez ID | 7189 |
| GenBank Protein ID | NM_004620.3; NM_145803.2; |
| GenBank Nucleotide ID | NP_004611.1; NP_665802.1; |
| Protein Name | TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6) |
| Gene Name | TRAF6; RNF85 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. |
| Sequence (Fasta) | MSLLNCENSC GSSQSESDCC VAMASSCSAV TKDDSVGGTA STGNLSSSFM EEIQGYDVEF 60 DPPLESKYEC PICLMALREA VQTPCGHRFC KACIIKSIRD AGHKCPVDNE ILLENQLFPD 120 NFAKREILSL MVKCPNEGCL HKMELRHLED HQAHCEFALM DCPQCQRPFQ KFHINIHILK 180 DCPRRQVSCD NCAASMAFED KEIHDQNCPL ANVICEYCNT ILIREQMPNH YDLDCPTAPI 240 PCTFSTFGCH EKMQRNHLAR HLQENTQSHM RMLAQAVHSL SVIPDSGYIS EVRNFQETIH 300 QLEGRLVRQD HQIRELTAKM ETQSMYVSEL KRTIRTLEDK VAEIEAQQCN GIYIWKIGNF 360 GMHLKCQEEE KPVVIHSPGF YTGKPGYKLC MRLHLQLPTA QRCANYISLF VHTMQGEYDS 420 HLPWPFQGTI RLTILDQSEA PVRQNHEEIM DAKPELLAFQ RPTIPRNPKG FGYVTFMHLE 480 ALRQRTFIKD DTLLVRCEVS TRFDMGSLRR EGFQPRSTDA GV 523 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 2) | MESH:D001172
; Arthritis, Rheumatoid MESH:D003324 ; Coronary Artery Disease |
| GWASdb (count: 4) | rs1046864; Multiple complex diseases; Null
rs5030445; Multiple complex diseases; Null rs540386; Multiple complex diseases; Null rs540386; Rheumatoid arthritis; rheumatoid arthritis |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 5) | 326 KMETQSMYVSELKRT dbPAF
353 AQQCNGIYIWKIGNF dbPAF 486 LEALRQRTFIKDDTL dbPAF 492 RTFIKDDTLLVRCEV dbPAF 507 STRFDMGSLRREGFQ dbPAF |
| Ubiquitination (count: 3) | 124 LFPDNFAKREILSLM PLMD
331 SMYVSELKRTIRTLE PLMD 489 LRQRTFIKDDTLLVR PLMD |
| Sumoylation (count: 3) | 124 LFPDNFAKREILSLM PLMD
142 PNEGCLHKMELRHLE PLMD 453 HEEIMDAKPELLAFQ PLMD |
| Glycation (count: 1) | 319 QIRELTAKMETQSMY PLMD |