Tag | Content |
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UniProt Accession | IRS2_HUMAN; Q9Y4H2; |
Entrez ID | 8660 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Insulin receptor substrate 2 (IRS-2) |
Gene Name | IRS2 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | May mediate the control of various cellular processes by insulin. |
Sequence (Fasta) | MASPPRHGPP GPASGDGPNL NNNNNNNNHS VRKCGYLRKQ KHGHKRFFVL RGPGAGGDEA 60 TAGGGSAPQP PRLEYYESEK KWRSKAGAPK RVIALDCCLN INKRADAKHK YLIALYTKDE 120 YFAVAAENEQ EQEGWYRALT DLVSEGRAAA GDAPPAAAPA ASCSASLPGA LGGSAGAAGA 180 EDSYGLVAPA TAAYREVWQV NLKPKGLGQS KNLTGVYRLC LSARTIGFVK LNCEQPSVTL 240 QLMNIRRCGH SDSFFFIEVG RSAVTGPGEL WMQADDSVVA QNIHETILEA MKALKELFEF 300 RPRSKSQSSG SSATHPISVP GARRHHHLVN LPPSQTGLVR RSRTDSLAAT PPAAKCSSCR 360 VRTASEGDGG AAAGAAAAGA RPVSVAGSPL SPGPVRAPLS RSHTLSGGCG GRGSKVALLP 420 AGGALQHSRS MSMPVAHSPP AATSPGSLSS SSGHGSGSYP PPPGPHPPLP HPLHHGPGQR 480 PSSGSASASG SPSDPGFMSL DEYGSSPGDL RAFCSHRSNT PESIAETPPA RDGGGGGEFY 540 GYMTMDRPLS HCGRSYRRVS GDAAQDLDRG LRKRTYSLTT PARQRPVPQP SSASLDEYTL 600 MRATFSGSAG RLCPSCPASS PKVAYHPYPE DYGDIEIGSH RSSSSNLGAD DGYMPMTPGA 660 ALAGSGSGSC RSDDYMPMSP ASVSAPKQIL QPRAAAAAAA AVPSAGPAGP APTSAAGRTF 720 PASGGGYKAS SPAESSPEDS GYMRMWCGSK LSMEHADGKL LPNGDYLNVS PSDAVTTGTP 780 PDFFSAALHP GGEPLRGVPG CCYSSLPRSY KAPYTCGGDS DQYVLMSSPV GRILEEERLE 840 PQATPGPSQA ASAFGAGPTQ PPHPVVPSPV RPSGGRPEGF LGQRGRAVRP TRLSLEGLPS 900 LPSMHEYPLP PEPKSPGEYI NIDFGEPGAR LSPPAPPLLA SAASSSSLLS ASSPASSLGS 960 GTPGTSSDSR QRSPLSDYMN LDFSSPKSPK PGAPSGHPVG SLDGLLSPEA SSPYPPLPPR 1020 PSASPSSSLQ PPPPPPAPGE LYRLPPASAV ATAQGPGAAS SLSSDTGDNG DYTEMAFGVA 1080 ATPPQPIAAP PKPEAARVAS PTSGVKRLSL MEQVSGVEAF LQASQPPDPH RGAKVIRADP 1140 QGGRRRHSSE TFSSTTTVTP VSPSFAHNPK RHNSASVENV SLRKSSEGGV GVGPGGGDEP 1200 PTSPRQLQPA PPLAPQGRPW TPGQPGGLVG CPGSGGSPMR RETSAGFQNG LNYIAIDVRE 1260 EPGLPPQPQP PPPPLPQPGD KSSWGRTRSL GGLISAVGVG STGGGCGGPG PGALPPANTY 1320 ASIDFLSHHL KEATIVKE 1339 |
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Database | Annotation |
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CTD (Curated) (count: 7) (view all) | MESH:D006528
; Carcinoma, Hepatocellular MESH:D003921 ; Diabetes Mellitus, Experimental MESH:D003924 ; Diabetes Mellitus, Type 2 MESH:D006943 ; Hyperglycemia MESH:D007333 ; Insulin Resistance MESH:D008527 ; Medulloblastoma |
HGMD (count: 11) (view all) | CM093132; Insulin resistance, severe ?; Missense/nonsense
CM093133; Insulin resistance, severe ?; Missense/nonsense CM093134; Insulin resistance, severe ?; Missense/nonsense CM995289; Diabetes, type 2 ?; Missense/nonsense CM093135; Insulin resistance, severe ?; Missense/nonsense CM093136; Insulin resistance, severe ?; Missense/nonsense |
GWASdb (count: 5) | rs9521509; Weight; obesity
rs4773088; Response to statin treatment (atorvastatin), change in cholesterol levels; cardiovascular system disease rs7999797; Body Mass Index; obesity rs7999797; Body Fat Distribution; obesity|heart disease rs7999797; Weight; obesity |
PTM | Modification Sites |
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Phosphorylation (count: 142) (view all) | 1082 MAFGVAATPPQPIAA dbPAF
1100 PEAARVASPTSGVKR dbPAF 1102 AARVASPTSGVKRLS dbPAF 1103 ARVASPTSGVKRLSL dbPAF 1109 TSGVKRLSLMEQVSG dbPAF 111 RADAKHKYLIALYTK dbPAF |
Ubiquitination (count: 4) | 295 LEAMKALKELFEFRP PLMD
622 SCPASSPKVAYHPYP PLMD 750 MRMWCGSKLSMEHAD PLMD 811 SSLPRSYKAPYTCGG PLMD |
Methylation (count: 2) | 1134 PDPHRGAKVIRADPQ PLMD
1170 PSFAHNPKRHNSASV PLMD |
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