Q9Y4H2

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession IRS2_HUMAN; Q9Y4H2;
Entrez ID 8660
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Insulin receptor substrate 2 (IRS-2)
Gene Name IRS2
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionMay mediate the control of various cellular processes by insulin.
Sequence
(Fasta)
MASPPRHGPP GPASGDGPNL NNNNNNNNHS VRKCGYLRKQ KHGHKRFFVL RGPGAGGDEA 60
TAGGGSAPQP PRLEYYESEK KWRSKAGAPK RVIALDCCLN INKRADAKHK YLIALYTKDE 120
YFAVAAENEQ EQEGWYRALT DLVSEGRAAA GDAPPAAAPA ASCSASLPGA LGGSAGAAGA 180
EDSYGLVAPA TAAYREVWQV NLKPKGLGQS KNLTGVYRLC LSARTIGFVK LNCEQPSVTL 240
QLMNIRRCGH SDSFFFIEVG RSAVTGPGEL WMQADDSVVA QNIHETILEA MKALKELFEF 300
RPRSKSQSSG SSATHPISVP GARRHHHLVN LPPSQTGLVR RSRTDSLAAT PPAAKCSSCR 360
VRTASEGDGG AAAGAAAAGA RPVSVAGSPL SPGPVRAPLS RSHTLSGGCG GRGSKVALLP 420
AGGALQHSRS MSMPVAHSPP AATSPGSLSS SSGHGSGSYP PPPGPHPPLP HPLHHGPGQR 480
PSSGSASASG SPSDPGFMSL DEYGSSPGDL RAFCSHRSNT PESIAETPPA RDGGGGGEFY 540
GYMTMDRPLS HCGRSYRRVS GDAAQDLDRG LRKRTYSLTT PARQRPVPQP SSASLDEYTL 600
MRATFSGSAG RLCPSCPASS PKVAYHPYPE DYGDIEIGSH RSSSSNLGAD DGYMPMTPGA 660
ALAGSGSGSC RSDDYMPMSP ASVSAPKQIL QPRAAAAAAA AVPSAGPAGP APTSAAGRTF 720
PASGGGYKAS SPAESSPEDS GYMRMWCGSK LSMEHADGKL LPNGDYLNVS PSDAVTTGTP 780
PDFFSAALHP GGEPLRGVPG CCYSSLPRSY KAPYTCGGDS DQYVLMSSPV GRILEEERLE 840
PQATPGPSQA ASAFGAGPTQ PPHPVVPSPV RPSGGRPEGF LGQRGRAVRP TRLSLEGLPS 900
LPSMHEYPLP PEPKSPGEYI NIDFGEPGAR LSPPAPPLLA SAASSSSLLS ASSPASSLGS 960
GTPGTSSDSR QRSPLSDYMN LDFSSPKSPK PGAPSGHPVG SLDGLLSPEA SSPYPPLPPR 1020
PSASPSSSLQ PPPPPPAPGE LYRLPPASAV ATAQGPGAAS SLSSDTGDNG DYTEMAFGVA 1080
ATPPQPIAAP PKPEAARVAS PTSGVKRLSL MEQVSGVEAF LQASQPPDPH RGAKVIRADP 1140
QGGRRRHSSE TFSSTTTVTP VSPSFAHNPK RHNSASVENV SLRKSSEGGV GVGPGGGDEP 1200
PTSPRQLQPA PPLAPQGRPW TPGQPGGLVG CPGSGGSPMR RETSAGFQNG LNYIAIDVRE 1260
EPGLPPQPQP PPPPLPQPGD KSSWGRTRSL GGLISAVGVG STGGGCGGPG PGALPPANTY 1320
ASIDFLSHHL KEATIVKE 1339

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationPolycystic ovary syndromeD15840293
[Reference]: The tyrosine phosphorylation of IRS-2 was significantly decreased in PCOS with insulin resistance 0.77 +/- 0.16 compared to that of PCOS without insulin resistance 0.91 +/- 0.25 and control groups 1.00 +/- 0.12 (P < 0.05).
2Serine PhosphorylationObesityPS39126657864
[Reference]: CDK4 is an essential insulin effector in adipocytes.
3Serine PhosphorylationOvarian cancer/carcinomaUS110017001009
[Reference]: Identification of class I MHC-associated phosphopeptides as targets for cancer immunotherapy.
4Serine PhosphorylationMelanomaUS110017001009
[Reference]: Identification of class I MHC-associated phosphopeptides as targets for cancer immunotherapy.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 7)
(view all)
MESH:D006528 ; Carcinoma, Hepatocellular
MESH:D003921 ; Diabetes Mellitus, Experimental
MESH:D003924 ; Diabetes Mellitus, Type 2
MESH:D006943 ; Hyperglycemia
MESH:D007333 ; Insulin Resistance
MESH:D008527 ; Medulloblastoma
HGMD
(count: 11)
(view all)
CM093132; Insulin resistance, severe ?; Missense/nonsense
CM093133; Insulin resistance, severe ?; Missense/nonsense
CM093134; Insulin resistance, severe ?; Missense/nonsense
CM995289; Diabetes, type 2 ?; Missense/nonsense
CM093135; Insulin resistance, severe ?; Missense/nonsense
CM093136; Insulin resistance, severe ?; Missense/nonsense
GWASdb
(count: 5)
rs9521509; Weight; obesity
rs4773088; Response to statin treatment (atorvastatin), change in cholesterol levels; cardiovascular system disease
rs7999797; Body Mass Index; obesity
rs7999797; Body Fat Distribution; obesity|heart disease
rs7999797; Weight; obesity

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 142)
(view all)
1082      MAFGVAATPPQPIAA     dbPAF
1100      PEAARVASPTSGVKR     dbPAF
1102      AARVASPTSGVKRLS     dbPAF
1103      ARVASPTSGVKRLSL     dbPAF
1109      TSGVKRLSLMEQVSG     dbPAF
111       RADAKHKYLIALYTK     dbPAF
Ubiquitination
(count: 4)
295       LEAMKALKELFEFRP     PLMD
622       SCPASSPKVAYHPYP     PLMD
750       MRMWCGSKLSMEHAD     PLMD
811       SSLPRSYKAPYTCGG     PLMD
Methylation
(count: 2)
1134      PDPHRGAKVIRADPQ     PLMD
1170      PSFAHNPKRHNSASV     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource