Tag | Content |
---|---|
UniProt Accession | TLN1_HUMAN; Q9Y490; |
Entrez ID | 7094 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Talin-1 |
Gene Name | TLN1; KIAA1027; TLN |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity). |
Sequence (Fasta) | MVALSLKISI GNVVKTMQFE PSTMVYDACR IIRERIPEAP AGPPSDFGLF LSDDDPKKGI 60 WLEAGKALDY YMLRNGDTME YRKKQRPLKI RMLDGTVKTI MVDDSKTVTD MLMTICARIG 120 ITNHDEYSLV RELMEEKKEE ITGTLRKDKT LLRDEKKMEK LKQKLHTDDE LNWLDHGRTL 180 REQGVEEHET LLLRRKFFYS DQNVDSRDPV QLNLLYVQAR DDILNGSHPV SFDKACEFAG 240 FQCQIQFGPH NEQKHKAGFL DLKDFLPKEY VKQKGERKIF QAHKNCGQMS EIEAKVRYVK 300 LARSLKTYGV SFFLVKEKMK GKNKLVPRLL GITKECVMRV DEKTKEVIQE WNLTNIKRWA 360 ASPKSFTLDF GDYQDGYYSV QTTEGEQIAQ LIAGYIDIIL KKKKSKDHFG LEGDEESTML 420 EDSVSPKKST VLQQQYNRVG KVEHGSVALP AIMRSGASGP ENFQVGSMPP AQQQITSGQM 480 HRGHMPPLTS AQQALTGTIN SSMQAVQAAQ ATLDDFDTLP PLGQDAASKA WRKNKMDESK 540 HEIHSQVDAI TAGTASVVNL TAGDPAETDY TAVGCAVTTI SSNLTEMSRG VKLLAALLED 600 EGGSGRPLLQ AAKGLAGAVS ELLRSAQPAS AEPRQNLLQA AGNVGQASGE LLQQIGESDT 660 DPHFQDALMQ LAKAVASAAA ALVLKAKSVA QRTEDSGLQT QVIAAATQCA LSTSQLVACT 720 KVVAPTISSP VCQEQLVEAG RLVAKAVEGC VSASQAATED GQLLRGVGAA ATAVTQALNE 780 LLQHVKAHAT GAGPAGRYDQ ATDTILTVTE NIFSSMGDAG EMVRQARILA QATSDLVNAI 840 KADAEGESDL ENSRKLLSAA KILADATAKM VEAAKGAAAH PDSEEQQQRL REAAEGLRMA 900 TNAAAQNAIK KKLVQRLEHA AKQAAASATQ TIAAAQHAAS TPKASAGPQP LLVQSCKAVA 960 EQIPLLVQGV RGSQAQPDSP SAQLALIAAS QSFLQPGGKM VAAAKASVPT IQDQASAMQL 1020 SQCAKNLGTA LAELRTAAQK AQEACGPLEM DSALSVVQNL EKDLQEVKAA ARDGKLKPLP 1080 GETMEKCTQD LGNSTKAVSS AIAQLLGEVA QGNENYAGIA ARDVAGGLRS LAQAARGVAA 1140 LTSDPAVQAI VLDTASDVLD KASSLIEEAK KAAGHPGDPE SQQRLAQVAK AVTQALNRCV 1200 SCLPGQRDVD NALRAVGDAS KRLLSDSLPP STGTFQEAQS RLNEAAAGLN QAATELVQAS 1260 RGTPQDLARA SGRFGQDFST FLEAGVEMAG QAPSQEDRAQ VVSNLKGISM SSSKLLLAAK 1320 ALSTDPAAPN LKSQLAAAAR AVTDSINQLI TMCTQQAPGQ KECDNALREL ETVRELLENP 1380 VQPINDMSYF GCLDSVMENS KVLGEAMTGI SQNAKNGNLP EFGDAISTAS KALCGFTEAA 1440 AQAAYLVGVS DPNSQAGQQG LVEPTQFARA NQAIQMACQS LGEPGCTQAQ VLSAATIVAK 1500 HTSALCNSCR LASARTTNPT AKRQFVQSAK EVANSTANLV KTIKALDGAF TEENRAQCRA 1560 ATAPLLEAVD NLSAFASNPE FSSIPAQISP EGRAAMEPIV ISAKTMLESA GGLIQTARAL 1620 AVNPRDPPSW SVLAGHSRTV SDSIKKLITS MRDKAPGQLE CETAIAALNS CLRDLDQASL 1680 AAVSQQLAPR EGISQEALHT QMLTAVQEIS HLIEPLANAA RAEASQLGHK VSQMAQYFEP 1740 LTLAAVGAAS KTLSHPQQMA LLDQTKTLAE SALQLLYTAK EAGGNPKQAA HTQEALEEAV 1800 QMMTEAVEDL TTTLNEAASA AGVVGGMVDS ITQAINQLDE GPMGEPEGSF VDYQTTMVRT 1860 AKAIAVTVQE MVTKSNTSPE ELGPLANQLT SDYGRLASEA KPAAVAAENE EIGSHIKHRV 1920 QELGHGCAAL VTKAGALQCS PSDAYTKKEL IECARRVSEK VSHVLAALQA GNRGTQACIT 1980 AASAVSGIIA DLDTTIMFAT AGTLNREGTE TFADHREGIL KTAKVLVEDT KVLVQNAAGS 2040 QEKLAQAAQS SVATITRLAD VVKLGAASLG AEDPETQVVL INAVKDVAKA LGDLISATKA 2100 AAGKVGDDPA VWQLKNSAKV MVTNVTSLLK TVKAVEDEAT KGTRALEATT EHIRQELAVF 2160 CSPEPPAKTS TPEDFIRMTK GITMATAKAV AAGNSCRQED VIATANLSRR AIADMLRACK 2220 EAAYHPEVAP DVRLRALHYG RECANGYLEL LDHVLLTLQK PSPELKQQLT GHSKRVAGSV 2280 TELIQAAEAM KGTEWVDPED PTVIAENELL GAAAAIEAAA KKLEQLKPRA KPKEADESLN 2340 FEEQILEAAK SIAAATSALV KAASAAQREL VAQGKVGAIP ANALDDGQWS QGLISAARMV 2400 AAATNNLCEA ANAAVQGHAS QEKLISSAKQ VAASTAQLLV ACKVKADQDS EAMKRLQAAG 2460 NAVKRASDNL VKAAQKAAAF EEQENETVVV KEKMVGGIAQ IIAAQEEMLR KERELEEARK 2520 KLAQIRQQQY KFLPSELRDE H 2542 |
|
Database | Annotation |
---|---|
CTD (Curated) (count: 2) | MESH:D009361
; Neoplasm Invasiveness MESH:D010024 ; Osteoporosis |
GWASdb (count: 6) | rs4879926; IgE levels in asthmatics; asthma
rs2295795; Obesity (extreme); obesity rs16932581; Multiple complex diseases; Null rs2295797; Obesity (extreme); obesity rs1534847; Obesity (extreme); obesity rs4142495; Obesity (extreme); obesity |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 107) (view all) | 1010 AAKASVPTIQDQASA dbPAF
1021 QASAMQLSQCAKNLG dbPAF 1029 QCAKNLGTALAELRT dbPAF 105 KTIMVDDSKTVTDML dbPAF 1055 LEMDSALSVVQNLEK dbPAF 1116 VAQGNENYAGIAARD dbPAF |
Acetylation (count: 35) (view all) | 1190 QRLAQVAKAVTQALN PLMD
1314 GISMSSSKLLLAAKA PLMD 1415 TGISQNAKNGNLPEF PLMD 1522 RTTNPTAKRQFVQSA PLMD 1541 NSTANLVKTIKALDG PLMD 1544 ANLVKTIKALDGAFT PLMD |
Ubiquitination (count: 43) (view all) | 1306 AQVVSNLKGISMSSS PLMD
138 RELMEEKKEEITGTL PLMD 1415 TGISQNAKNGNLPEF PLMD 149 TGTLRKDKTLLRDEK PLMD 1530 RQFVQSAKEVANSTA PLMD 1541 NSTANLVKTIKALDG PLMD |
Glycation (count: 20) (view all) | 1730 EASQLGHKVSQMAQY PLMD
1766 MALLDQTKTLAESAL PLMD 1780 LQLLYTAKEAGGNPK PLMD 1960 CARRVSEKVSHVLAA PLMD 2024 EGILKTAKVLVEDTK PLMD 2089 NAVKDVAKALGDLIS PLMD |
Malonylation (count: 32) (view all) | 1068 EKDLQEVKAAARDGK PLMD
1170 SSLIEEAKKAAGHPG PLMD 1190 QRLAQVAKAVTQALN PLMD 1306 AQVVSNLKGISMSSS PLMD 1314 GISMSSSKLLLAAKA PLMD 1332 DPAAPNLKSQLAAAA PLMD |
Network | Interaction | ||
---|---|---|---|
A | B | Source | |