Q9Y490

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession TLN1_HUMAN; Q9Y490;
Entrez ID 7094
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Talin-1
Gene Name TLN1; KIAA1027; TLN
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionProbably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).
Sequence
(Fasta)
MVALSLKISI GNVVKTMQFE PSTMVYDACR IIRERIPEAP AGPPSDFGLF LSDDDPKKGI 60
WLEAGKALDY YMLRNGDTME YRKKQRPLKI RMLDGTVKTI MVDDSKTVTD MLMTICARIG 120
ITNHDEYSLV RELMEEKKEE ITGTLRKDKT LLRDEKKMEK LKQKLHTDDE LNWLDHGRTL 180
REQGVEEHET LLLRRKFFYS DQNVDSRDPV QLNLLYVQAR DDILNGSHPV SFDKACEFAG 240
FQCQIQFGPH NEQKHKAGFL DLKDFLPKEY VKQKGERKIF QAHKNCGQMS EIEAKVRYVK 300
LARSLKTYGV SFFLVKEKMK GKNKLVPRLL GITKECVMRV DEKTKEVIQE WNLTNIKRWA 360
ASPKSFTLDF GDYQDGYYSV QTTEGEQIAQ LIAGYIDIIL KKKKSKDHFG LEGDEESTML 420
EDSVSPKKST VLQQQYNRVG KVEHGSVALP AIMRSGASGP ENFQVGSMPP AQQQITSGQM 480
HRGHMPPLTS AQQALTGTIN SSMQAVQAAQ ATLDDFDTLP PLGQDAASKA WRKNKMDESK 540
HEIHSQVDAI TAGTASVVNL TAGDPAETDY TAVGCAVTTI SSNLTEMSRG VKLLAALLED 600
EGGSGRPLLQ AAKGLAGAVS ELLRSAQPAS AEPRQNLLQA AGNVGQASGE LLQQIGESDT 660
DPHFQDALMQ LAKAVASAAA ALVLKAKSVA QRTEDSGLQT QVIAAATQCA LSTSQLVACT 720
KVVAPTISSP VCQEQLVEAG RLVAKAVEGC VSASQAATED GQLLRGVGAA ATAVTQALNE 780
LLQHVKAHAT GAGPAGRYDQ ATDTILTVTE NIFSSMGDAG EMVRQARILA QATSDLVNAI 840
KADAEGESDL ENSRKLLSAA KILADATAKM VEAAKGAAAH PDSEEQQQRL REAAEGLRMA 900
TNAAAQNAIK KKLVQRLEHA AKQAAASATQ TIAAAQHAAS TPKASAGPQP LLVQSCKAVA 960
EQIPLLVQGV RGSQAQPDSP SAQLALIAAS QSFLQPGGKM VAAAKASVPT IQDQASAMQL 1020
SQCAKNLGTA LAELRTAAQK AQEACGPLEM DSALSVVQNL EKDLQEVKAA ARDGKLKPLP 1080
GETMEKCTQD LGNSTKAVSS AIAQLLGEVA QGNENYAGIA ARDVAGGLRS LAQAARGVAA 1140
LTSDPAVQAI VLDTASDVLD KASSLIEEAK KAAGHPGDPE SQQRLAQVAK AVTQALNRCV 1200
SCLPGQRDVD NALRAVGDAS KRLLSDSLPP STGTFQEAQS RLNEAAAGLN QAATELVQAS 1260
RGTPQDLARA SGRFGQDFST FLEAGVEMAG QAPSQEDRAQ VVSNLKGISM SSSKLLLAAK 1320
ALSTDPAAPN LKSQLAAAAR AVTDSINQLI TMCTQQAPGQ KECDNALREL ETVRELLENP 1380
VQPINDMSYF GCLDSVMENS KVLGEAMTGI SQNAKNGNLP EFGDAISTAS KALCGFTEAA 1440
AQAAYLVGVS DPNSQAGQQG LVEPTQFARA NQAIQMACQS LGEPGCTQAQ VLSAATIVAK 1500
HTSALCNSCR LASARTTNPT AKRQFVQSAK EVANSTANLV KTIKALDGAF TEENRAQCRA 1560
ATAPLLEAVD NLSAFASNPE FSSIPAQISP EGRAAMEPIV ISAKTMLESA GGLIQTARAL 1620
AVNPRDPPSW SVLAGHSRTV SDSIKKLITS MRDKAPGQLE CETAIAALNS CLRDLDQASL 1680
AAVSQQLAPR EGISQEALHT QMLTAVQEIS HLIEPLANAA RAEASQLGHK VSQMAQYFEP 1740
LTLAAVGAAS KTLSHPQQMA LLDQTKTLAE SALQLLYTAK EAGGNPKQAA HTQEALEEAV 1800
QMMTEAVEDL TTTLNEAASA AGVVGGMVDS ITQAINQLDE GPMGEPEGSF VDYQTTMVRT 1860
AKAIAVTVQE MVTKSNTSPE ELGPLANQLT SDYGRLASEA KPAAVAAENE EIGSHIKHRV 1920
QELGHGCAAL VTKAGALQCS PSDAYTKKEL IECARRVSEK VSHVLAALQA GNRGTQACIT 1980
AASAVSGIIA DLDTTIMFAT AGTLNREGTE TFADHREGIL KTAKVLVEDT KVLVQNAAGS 2040
QEKLAQAAQS SVATITRLAD VVKLGAASLG AEDPETQVVL INAVKDVAKA LGDLISATKA 2100
AAGKVGDDPA VWQLKNSAKV MVTNVTSLLK TVKAVEDEAT KGTRALEATT EHIRQELAVF 2160
CSPEPPAKTS TPEDFIRMTK GITMATAKAV AAGNSCRQED VIATANLSRR AIADMLRACK 2220
EAAYHPEVAP DVRLRALHYG RECANGYLEL LDHVLLTLQK PSPELKQQLT GHSKRVAGSV 2280
TELIQAAEAM KGTEWVDPED PTVIAENELL GAAAAIEAAA KKLEQLKPRA KPKEADESLN 2340
FEEQILEAAK SIAAATSALV KAASAAQREL VAQGKVGAIP ANALDDGQWS QGLISAARMV 2400
AAATNNLCEA ANAAVQGHAS QEKLISSAKQ VAASTAQLLV ACKVKADQDS EAMKRLQAAG 2460
NAVKRASDNL VKAAQKAAAF EEQENETVVV KEKMVGGIAQ IIAAQEEMLR KERELEEARK 2520
KLAQIRQQQY KFLPSELRDE H 2542

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationProstate cancer/carcinoma/adenocarcinomaUS42524793790
[Reference]: We next showed that talin1 S425 phosphorylation, but not total talin1 expression, correlates with metastatic potential of PCa cells.?

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 2)
MESH:D009361 ; Neoplasm Invasiveness
MESH:D010024 ; Osteoporosis
GWASdb
(count: 6)
rs4879926; IgE levels in asthmatics; asthma
rs2295795; Obesity (extreme); obesity
rs16932581; Multiple complex diseases; Null
rs2295797; Obesity (extreme); obesity
rs1534847; Obesity (extreme); obesity
rs4142495; Obesity (extreme); obesity

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 107)
(view all)
1010      AAKASVPTIQDQASA     dbPAF
1021      QASAMQLSQCAKNLG     dbPAF
1029      QCAKNLGTALAELRT     dbPAF
105       KTIMVDDSKTVTDML     dbPAF
1055      LEMDSALSVVQNLEK     dbPAF
1116      VAQGNENYAGIAARD     dbPAF
Acetylation
(count: 35)
(view all)
1190      QRLAQVAKAVTQALN     PLMD
1314      GISMSSSKLLLAAKA     PLMD
1415      TGISQNAKNGNLPEF     PLMD
1522      RTTNPTAKRQFVQSA     PLMD
1541      NSTANLVKTIKALDG     PLMD
1544      ANLVKTIKALDGAFT     PLMD
Ubiquitination
(count: 43)
(view all)
1306      AQVVSNLKGISMSSS     PLMD
138       RELMEEKKEEITGTL     PLMD
1415      TGISQNAKNGNLPEF     PLMD
149       TGTLRKDKTLLRDEK     PLMD
1530      RQFVQSAKEVANSTA     PLMD
1541      NSTANLVKTIKALDG     PLMD
Glycation
(count: 20)
(view all)
1730      EASQLGHKVSQMAQY     PLMD
1766      MALLDQTKTLAESAL     PLMD
1780      LQLLYTAKEAGGNPK     PLMD
1960      CARRVSEKVSHVLAA     PLMD
2024      EGILKTAKVLVEDTK     PLMD
2089      NAVKDVAKALGDLIS     PLMD
Malonylation
(count: 32)
(view all)
1068      EKDLQEVKAAARDGK     PLMD
1170      SSLIEEAKKAAGHPG     PLMD
1190      QRLAQVAKAVTQALN     PLMD
1306      AQVVSNLKGISMSSS     PLMD
1314      GISMSSSKLLLAAKA     PLMD
1332      DPAAPNLKSQLAAAA     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource