Q9Y261

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	FOXA2_HUMAN; Q9Y261;
Entrez ID	3170
GenBank Protein ID	NM_021784.4; NM_153675.2;
GenBank Nucleotide ID	NP_068556.2; NP_710141.1;
Protein Name	Hepatocyte nuclear factor 3-beta (HNF-3-beta) (HNF-3B) (Forkhead box protein A2) (Transcription factor 3B) (TCF-3B)
Gene Name	FOXA2; HNF3B; TCF3B
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formati(view all) Functional Description Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
Sequence (Fasta)	MLGAVKMEGH EPSDWSSYYA EPEGYSSVSN MNAGLGMNGM NTYMSMSAAA MGSGSGNMSA 60 GSMNMSSYVG AGMSPSLAGM SPGAGAMAGM GGSAGAAGVA GMGPHLSPSL SPLGGQAAGA 120 MGGLAPYANM NSMSPMYGQA GLSRARDPKT YRRSYTHAKP PYSYISLITM AIQQSPNKML 180 TLSEIYQWIM DLFPFYRQNQ QRWQNSIRHS LSFNDCFLKV PRSPDKPGKG SFWTLHPDSG 240 NMFENGCYLR RQKRFKCEKQ LALKEAAGAA GSGKKAAAGA QASQAQLGEA AGPASETPAG 300 TESPHSSASP CQEHKRGGLG ELKGTPAAAL SPPEPAPSPG QQQQAAAHLL GPPHHPGLPP 360 EAHLKPEHHY AFNHPFSINN LMSSEQQHHH SHHHHQPHKM DLKAYEQVMH YPGYGSPMPG 420 SLAMGPVTNK TGLDASPLAA DTSYYQGVYS RPIMNSS 458 Fasta Sequence >Q9Y261\|FOXA2; HNF3B; TCF3B\|Homo sapiens (Human) MLGAVKMEGHEPSDWSSYYAEPEGYSSVSNMNAGLGMNGMNTYMSMSAAAMGSGSGNMSAGSMNMSSYVGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPKTYRRSYTHAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFYRQNQQRWQNSIRHSLSFNDCFLKVPRSPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKCEKQLALKEAAGAAGSGKKAAAGAQASQAQLGEAAGPASETPAGTESPHSSASPCQEHKRGGLGELKGTPAAALSPPEPAPSPGQQQQAAAHLLGPPHHPGLPPEAHLKPEHHYAFNHPFSINNLMSSEQQHHHSHHHHQPHKMDLKAYEQVMHYPGYGSPMPGSLAMGPVTNKTGLDASPLAADTSYYQGVYSRPIMNSS

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Serine Phosphorylation	Liver cancer	Hep3B cell line	P	S107/111	22196886
1	[Reference]: Here, we show that IKK, an important downstream kinase of TNF, interacts with and phosphorylates FOXA2 at S107/S111, thereby suppressing FOXA2 transactivation activity and leading to decreased NUMB expression, and further activates the downstream NOTCH pathway and promotes cell proliferation and tumorigenesis
2	Serine Phosphorylation	Hepatocellular carcinoma/Hepatocarcinoma/Hepatoma		U	S107	22196886
2	[Reference]: Moreover, we found that levels of IKK?, pFOXA2 (S107/111), and activated NOTCH1 were significantly higher in hepatocellular carcinoma tumors than in normal liver tissues and that pFOXA2 (S107/111) expression was positively correlated with IKK? and activated NOTCH1 expression in tumor tissues.
3	Serine Phosphorylation	Hepatocellular carcinoma/Hepatocarcinoma/Hepatoma		U	S111	22196886
3	[Reference]: Moreover, we found that levels of IKK?, pFOXA2 (S107/111), and activated NOTCH1 were significantly higher in hepatocellular carcinoma tumors than in normal liver tissues and that pFOXA2 (S107/111) expression was positively correlated with IKK? and activated NOTCH1 expression in tumor tissues.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 3)	MESH:D006548 ; Hernia, Diaphragmatic MESH:D008106 ; Liver Cirrhosis, Experimental MESH:D008171 ; Lung Diseases
DisGeNet (Curated) (count: 3)	C0019284; Diaphragmatic Hernia C0023893; Liver Cirrhosis, Experimental C0024115; Lung diseases
HGMD (count: 3)	CM005502; Impaired glucose homeostasis ?; Missense/nonsense CM000518; Diabetes, early-onset, MODY; Missense/nonsense CM005501; Impaired glucose homeostasis ?; Missense/nonsense

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 10) (view all)	107 AGMGPHLSPSLSPLG dbPAF 111 PHLSPSLSPLGGQAA dbPAF 156 KTYRRSYTHAKPPYS dbPAF 223 CFLKVPRSPDKPGKG dbPAF 295 GEAAGPASETPAGTE dbPAF 301 ASETPAGTESPHSSA dbPAF 303 ETPAGTESPHSSASP dbPAF 306 AGTESPHSSASPCQE dbPAF 307 GTESPHSSASPCQEH dbPAF 309 ESPHSSASPCQEHKR dbPAF

※ Protein-Protein Interaction

Network

Interaction

A

B

Source

MINT