Q9Y238

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession DLEC1_HUMAN; Q9Y238;
Entrez ID 9940
GenBank Protein ID NM_001321153.1; NM_007335.3; NM_007337.3;
GenBank Nucleotide ID NP_001308082.1; NP_031361.2; NP_031363.2;
Protein Name Deleted in lung and esophageal cancer protein 1 (Deleted in lung cancer protein 1) (DLC-1)
Gene Name DLEC1; DLC1
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionMay act as a tumor suppressor by inhibiting cell proliferation.
Sequence
(Fasta)
METRSSKTRR SLASRTNECQ GTMWAPTSPP AGSSSPSQPT WKSSLYSSLA YSEAFHYSFA 60
ARPRRLTQLA LAQRPEPQLL RLRPSSLRTQ DISHLLTGVF RNLYSAEVIG DEVSASLIKA 120
RGSENERHEE FVDQLQQIRE LYKQRLDEFE MLERHITQAQ ARAIAENERV MSQAGVQDLE 180
SLVRLPPVKS VSRWCIDSEL LRKHHLISPE DYYTDTVPFH SAPKGISLPG CSKLTFSCEK 240
RSVQKKELNK KLEDSCRKKL AEFEDELDHT VDSLTWNLTP KAKERTREPL KKASQPRNKN 300
WMNHLRVPQR ELDRLLLARM ESRNHFLKNP RFFPPNTRYG GKSLVFPPKK PAPIGEFQST 360
EPEQSCADTP VFLAKPPIGF FTDYEIGPVY EMVIALQNTT TTSRYLRVLP PSTPYFALGL 420
GMFPGKGGMV APGMTCQYIV QFFPDCLGDF DDFILVETQS AHTLLIPLQA RRPPPVLTLS 480
PVLDCGYCLI GGVKMTRFIC KNVGFSVGRF CIMPKTSWPP LSFKAIATVG FVEQPPFGIL 540
PSVFELAPGH AILVEVLFSP KSLGKAEQTF IIMCDNCQIK ELVTIGIGQL IALDLIYISG 600
EKSQPDPGEL TDLTAQHFIR FEPENLRSTA RKQLIIRNAT HVELAFYWQI MKPNLQPLMP 660
GETFSMDSIK CYPDKETAFS IMPRKGVLSP HTDHEFILSF SPHELRDFHS VLQMVLEEVP 720
EPVSSEAESL GHSSYSVDDV IVLEIEVKGS VEPFQVLLEP YALIIPGENY IGINVKKAFK 780
MWNNSKSPIR YLWGKISDCH IIEVEPGTGV IEPSEVGDFE LNFTGGVPGP TSQDLLCEIE 840
DSPSPVVLHI EAVFKGPALI INVSALQFGL LRLGQKATNS IQIRNVSQLP ATWRMKESPV 900
SLQERPEDVS PFDIEPSSGQ LHSLGECRVD ITLEALHCQH LETVLELEVE NGAWSYLPVY 960
AEVQKPHVYL QSSQVEVRNL YLGVPTKTTI TLINGTLLPT QFHWGKLLGH QAEFCMVTVS 1020
PKHGLLGPSE ECQLKLELTA HTQEELTHLA LPCHVSGMKK PLVLGISGKP QGLQVAITIS 1080
KESSDCSTEQ WPGHPKELRL DFGSAVPLRT RVTRQLILTN RSPIRTRFSL KFEYFGSPQN 1140
SLSKKTSLPN MPPALLKTVR MQEHLAKREQ LDFMESMLSH GKGAAFFPHF SQGMLGPYQQ 1200
LCIDITGCAN MWGEYWDNLI CTVGDLLPEV IPVHMAAVGC PISSLRTTSY TIDQAQKEPA 1260
MRFGTQVSGG DTVTRTLRLN NSSPCDIRLD WETYVPEDKE DRLVELLVFY GPPFPLRDQA 1320
GNELVCPDTP EGGCLLWSPG PSSSSEFSHE TDSSVEGSSS ASNRVAQKLI SVILQAHEGV 1380
PSGHLYCISP KQVVVPAGGS STIYISFTPM VLSPEILHKV ECTGYALGFM SLDSKVEREI 1440
PGKRHRLQDF AVGPLKLDLH SYVRPAQLSV ELDYGGSMEF QCQASDLIPE QPCSGVLSEL 1500
VTTHHLKLTN TTEIPHYFRL MVSRPFSVSQ DGASQDHRAP GPGQKQECEE ETASADKQLV 1560
LQAQENMLVN VSFSLSLELL SYQKLPADQT LPGVDIQQSA SGEREMVFTQ NLLLEYTNQT 1620
TQVVPLRAVV AVPELQLSTS WVDFGTCFVS QQRVREVYLM NLSGCRSYWT MLMGQQEPAK 1680
AAVAFRVSPN SGLLEARSAN APPTSIALQV FFTARSSELY ESTMVVEGVL GEKSCTLRLR 1740
GQGSYDERYM LPHQP 1756

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PolyubiquitinationNon-small cell lung cancer/carcinomaH1299 cell lineP24082123
[Reference]: After FBXW5 depletion, we determined that DLC1 polyubiquitination was decreased significantly (Fig. 3F) and the level of endogenous DLC1 was greatly increased in H1299 cells

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 2)
MESH:D004938 ; Esophageal Neoplasms
MESH:D008175 ; Lung Neoplasms
GWASdb
(count: 4)
rs1123569; Multiple complex diseases; Null
rs9847922; Multiple complex diseases; Null
rs9847922; Urinary metabolites; kidney disease
rs6599263; Urinary metabolites; kidney disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 8)
(view all)
1134      RFSLKFEYFGSPQNS     dbPAF
1141      YFGSPQNSLSKKTSL     dbPAF
1147      NSLSKKTSLPNMPPA     dbPAF
1354      FSHETDSSVEGSSSA     dbPAF
322       LLLARMESRNHFLKN     dbPAF
337       PRFFPPNTRYGGKSL     dbPAF