| Tag | Content |
|---|---|
| UniProt Accession | RUVB2_HUMAN; Q9Y230; |
| Entrez ID | 10856 |
| GenBank Protein ID | NM_001321191.1; NM_006666.2; XM_011526330.1; |
| GenBank Nucleotide ID | NP_001308120.1; NP_006657.1; XP_011524632.1; |
| Protein Name | RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protei |
| Gene Name | RUVBL2; INO80J; TIP48; TIP49B; CGI-46 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity.;Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other (view all) |
| Sequence (Fasta) | MATVTATTKV PEIRDVTRIE RIGAHSHIRG LGLDDALEPR QASQGMVGQL AARRAAGVVL 60 EMIREGKIAG RAVLIAGQPG TGKTAIAMGM AQALGPDTPF TAIAGSEIFS LEMSKTEALT 120 QAFRRSIGVR IKEETEIIEG EVVEIQIDRP ATGTGSKVGK LTLKTTEMET IYDLGTKMIE 180 SLTKDKVQAG DVITIDKATG KISKLGRSFT RARDYDAMGS QTKFVQCPDG ELQKRKEVVH 240 TVSLHEIDVI NSRTQGFLAL FSGDTGEIKS EVREQINAKV AEWREEGKAE IIPGVLFIDE 300 VHMLDIESFS FLNRALESDM APVLIMATNR GITRIRGTSY QSPHGIPIDL LDRLLIVSTT 360 PYSEKDTKQI LRIRCEEEDV EMSEDAYTVL TRIGLETSLR YAIQLITAAS LVCRKRKGTE 420 VQVDDIKRVY SLFLDESRST QYMKEYQDAF LFNELKGETM DTS 464 |
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| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 27) (view all) | 110 IAGSEIFSLEMSKTE dbPAF
172 TTEMETIYDLGTKMI dbPAF 181 LGTKMIESLTKDKVQ dbPAF 215 SFTRARDYDAMGSQT dbPAF 220 RDYDAMGSQTKFVQC dbPAF 222 YDAMGSQTKFVQCPD dbPAF |
| Acetylation (count: 10) (view all) | 160 GTGSKVGKLTLKTTE PLMD
186 IESLTKDKVQAGDVI PLMD 197 GDVITIDKATGKISK PLMD 223 DAMGSQTKFVQCPDG PLMD 234 CPDGELQKRKEVVHT PLMD 279 VREQINAKVAEWREE PLMD |
| Ubiquitination (count: 19) (view all) | 132 RSIGVRIKEETEIIE PLMD
160 GTGSKVGKLTLKTTE PLMD 164 KVGKLTLKTTEMETI PLMD 177 TIYDLGTKMIESLTK PLMD 184 KMIESLTKDKVQAGD PLMD 186 IESLTKDKVQAGDVI PLMD |
| Sumoylation (count: 2) | 456 AFLFNELKGETMDTS PLMD
9 ATVTATTKVPEIRDV PLMD |
| Malonylation (count: 3) | 365 STTPYSEKDTKQILR PLMD
368 PYSEKDTKQILRIRC PLMD 427 EVQVDDIKRVYSLFL PLMD |
| Methylation (count: 2) | 415 AASLVCRKRKGTEVQ PLMD
67 LEMIREGKIAGRAVL PLMD |